ID A0A0K9XFI1_9ACTN Unreviewed; 747 AA.
AC A0A0K9XFI1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=AC230_16095 {ECO:0000313|EMBL:KNB51831.1};
OS Streptomyces caatingaensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1678637 {ECO:0000313|EMBL:KNB51831.1, ECO:0000313|Proteomes:UP000037288};
RN [1] {ECO:0000313|Proteomes:UP000037288}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CMAA 1322 {ECO:0000313|Proteomes:UP000037288};
RA Santos S.N., Gacesa R., Taketani R.G., Long P.F., Melo I.S.;
RT "Draft genome sequence of Streptomyces sp. CMAA 1322, a bacterium isolated
RT from Caatinga biome, from dry forest semiarid of Brazil.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNB51831.1}.
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DR EMBL; LFXA01000009; KNB51831.1; -; Genomic_DNA.
DR RefSeq; WP_049716843.1; NZ_LFXA01000009.1.
DR AlphaFoldDB; A0A0K9XFI1; -.
DR STRING; 1678637.AC230_16095; -.
DR PATRIC; fig|1678637.3.peg.3470; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000037288; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF45; ATP-DEPENDENT DNA HELICASE UVRD2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000037288}.
FT DOMAIN 22..302
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 303..559
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT DOMAIN 660..740
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 568..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 43..50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 747 AA; 80969 MW; 881CA1DFB56CA407 CRC64;
MTPATHSPLF PQVPETADAV LDGLDPEQRA VATALKGPVC VLAGAGTGKT RAITHRIAYG
VRSGVLQPAS VLAVTFTNRA AGEMRGRLRQ LGATGVQART FHSAALRQLQ YFWPKAVGGE
LPRLVERKAQ LVSEAAARCR VRLDRGELRD TTSEIEWAKV TQTVPEEYPA AVARCAREAP
RDPAETARIY GVYEQLKRER GVIDFEDVLL LTVGVLQDRH DIAETVRRQY QHFVVDEYQD
VSPLQQRLLE LWLGDRDSLC VVGDASQTIY SFTGATPDHL LDFRSRHPGA TVVRLVRDYR
STPQVVRLAN GLLAQARGRA ADHRLELVSQ REDGPEPAYA EFADEPAEAE GVARRVRDLI
ASGVPAAEIA ILYRVNAQSE GYEQALADAG VPYQLRGAER FFERPEVREA QVLLRGAARA
ADGTDPRLAA AEDLPGQVRA VFSTRGWTPE PPAGSGAARD RWESLAALVR LAEDFARSRP
GATLADLVTE LHERAEAQHA PTVEGVTLAS LHAAKGLEWD AVFLVGLTEG MLPITYAKTD
EQIEEERRLL YVGVTRARRH LTLSWALSRA PGGRPSRRPS RFLAGLRPGS RAPRPGGAEA
AGPLGHVSYG SGAYASGGRS PGDGGAGRAA RRRPARCRVC GRTLTDAGEI KLLRCEDCPS
ELDEGLHERL LDWRAEQAAR LGQPAFCVFT DKTLLAIAEA VPGTEAELAV ISGVGRRKLG
TFGADVLALC AGREPESQKG PEISPEK
//
