ID A0A0L0BTQ9_LUCCU Unreviewed; 918 AA.
AC A0A0L0BTQ9;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=FF38_00747 {ECO:0000313|EMBL:KNC23386.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC23386.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC23386.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC23386.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC23386.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC23386.1}.
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DR EMBL; JRES01001352; KNC23386.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0BTQ9; -.
DR STRING; 7375.A0A0L0BTQ9; -.
DR EnsemblMetazoa; KNC23386; KNC23386; FF38_00747.
DR OMA; RPWVLNE; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF530; TOLL-9, ISOFORM A; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..918
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005535062"
FT TRANSMEM 701..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 760..906
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 918 AA; 106519 MW; E3A8010EE97CB02F CRC64;
MFVIFKIKTF TKLLIWWWCW WCLSCKGINS SAISPQFNDN NNNFYKDNFN LHNNAKLATQ
SDLEETIITA DDIEYTTPYA TPGVTWDTEE KLLENSLVKL KTTNEENSCL LDSLKTALLW
WSYGNGTLRE TNLRVLTKQQ QLDLSYRNIS KDGELLQLMR SSNKDLESLN VVAASLAYNN
LTNVPYKSME LMSNSLKYLS LRGNPFMDIN SEIEDRNLHC LLLNEEDDKQ NRKIFTKSEE
GIAWATFPYM PQLLELDISN CDIEFISKMA FKNLTNLKNL YMSYNKMLTL KSDTFHYTPH
LQVLDLSFTN VYDTFMNQLV ASPTLESVMK LIYGLNIQQY TFKYLPNLAY LDLSHTKLTR
GSAIAFTHLG PNLKYLSLCY TSFPVFGNGI FKNSSLIGLD LSGNTHAAFS ITEDVFEDLS
KTLSYLYFEK ANLKDLSWLK HLHNLRFLAL AGNNINTLTF EHFQNLPQLQ VLDLTSNQVG
NWYNQVFVNN TNLRVLSLKD NNINIITSEM LKDFSNLIYL SLGDNNFICD CLLRDLVDIA
ALNNKQATCQ GNIWQDLHNT LNISGNHLQL ILEHSKLFLN TSLQNLDVQS VVWSQSLEKL
RQSTRKLSMT NKFKSSPKMR FILDALRTVN VSKICHHYNN TSNDYDERLN GTLNKVQLLD
YEEDHYWCYN ETEKQTLIRL NCQRASLVDD IVEELDSLTT YVIAIVGSLI AITVICLLVY
WKRWHIYYYY SSLKSAALLS SVSQENINKF QNLCDQQPHM IYDIFISYCQ SDRDWIVQEL
MPNVEDSGDI SICLHERDFQ IGVTILDNIV SCMERSKALM LIISSNFLLS HWCQFEMQLA
QHRMFDLNKD HLILVFLEEI PRSKRPKNLQ YLMDVKTYIK WPGGKGKRHI QPEERKLFWK
RLKRTLSNIG LNATESRA
//