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Database: UniProt
Entry: A0A0L0BTQ9_LUCCU
LinkDB: A0A0L0BTQ9_LUCCU
Original site: A0A0L0BTQ9_LUCCU 
ID   A0A0L0BTQ9_LUCCU        Unreviewed;       918 AA.
AC   A0A0L0BTQ9;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=FF38_00747 {ECO:0000313|EMBL:KNC23386.1};
OS   Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Calliphoridae; Luciliinae; Lucilia.
OX   NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC23386.1, ECO:0000313|Proteomes:UP000037069};
RN   [1] {ECO:0000313|EMBL:KNC23386.1, ECO:0000313|Proteomes:UP000037069}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LS {ECO:0000313|EMBL:KNC23386.1,
RC   ECO:0000313|Proteomes:UP000037069};
RC   TISSUE=Full body {ECO:0000313|EMBL:KNC23386.1};
RX   PubMed=26108605; DOI=10.1038/ncomms8344;
RA   Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA   Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA   Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA   Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA   Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA   Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT   "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT   interventions.";
RL   Nat. Commun. 6:7344-7344(2015).
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KNC23386.1}.
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DR   EMBL; JRES01001352; KNC23386.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L0BTQ9; -.
DR   STRING; 7375.A0A0L0BTQ9; -.
DR   EnsemblMetazoa; KNC23386; KNC23386; FF38_00747.
DR   OMA; RPWVLNE; -.
DR   Proteomes; UP000037069; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365:SF530; TOLL-9, ISOFORM A; 1.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   Pfam; PF13306; LRR_5; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..918
FT                   /note="TIR domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005535062"
FT   TRANSMEM        701..721
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          760..906
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   918 AA;  106519 MW;  E3A8010EE97CB02F CRC64;
     MFVIFKIKTF TKLLIWWWCW WCLSCKGINS SAISPQFNDN NNNFYKDNFN LHNNAKLATQ
     SDLEETIITA DDIEYTTPYA TPGVTWDTEE KLLENSLVKL KTTNEENSCL LDSLKTALLW
     WSYGNGTLRE TNLRVLTKQQ QLDLSYRNIS KDGELLQLMR SSNKDLESLN VVAASLAYNN
     LTNVPYKSME LMSNSLKYLS LRGNPFMDIN SEIEDRNLHC LLLNEEDDKQ NRKIFTKSEE
     GIAWATFPYM PQLLELDISN CDIEFISKMA FKNLTNLKNL YMSYNKMLTL KSDTFHYTPH
     LQVLDLSFTN VYDTFMNQLV ASPTLESVMK LIYGLNIQQY TFKYLPNLAY LDLSHTKLTR
     GSAIAFTHLG PNLKYLSLCY TSFPVFGNGI FKNSSLIGLD LSGNTHAAFS ITEDVFEDLS
     KTLSYLYFEK ANLKDLSWLK HLHNLRFLAL AGNNINTLTF EHFQNLPQLQ VLDLTSNQVG
     NWYNQVFVNN TNLRVLSLKD NNINIITSEM LKDFSNLIYL SLGDNNFICD CLLRDLVDIA
     ALNNKQATCQ GNIWQDLHNT LNISGNHLQL ILEHSKLFLN TSLQNLDVQS VVWSQSLEKL
     RQSTRKLSMT NKFKSSPKMR FILDALRTVN VSKICHHYNN TSNDYDERLN GTLNKVQLLD
     YEEDHYWCYN ETEKQTLIRL NCQRASLVDD IVEELDSLTT YVIAIVGSLI AITVICLLVY
     WKRWHIYYYY SSLKSAALLS SVSQENINKF QNLCDQQPHM IYDIFISYCQ SDRDWIVQEL
     MPNVEDSGDI SICLHERDFQ IGVTILDNIV SCMERSKALM LIISSNFLLS HWCQFEMQLA
     QHRMFDLNKD HLILVFLEEI PRSKRPKNLQ YLMDVKTYIK WPGGKGKRHI QPEERKLFWK
     RLKRTLSNIG LNATESRA
//
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