ID A0A0L0BXM8_LUCCU Unreviewed; 1319 AA.
AC A0A0L0BXM8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=E3 ubiquitin-protein ligase SHPRH {ECO:0008006|Google:ProtNLM};
GN ORFNames=FF38_04850 {ECO:0000313|EMBL:KNC24755.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC24755.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC24755.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC24755.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC24755.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC24755.1}.
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DR EMBL; JRES01001179; KNC24755.1; -; Genomic_DNA.
DR STRING; 7375.A0A0L0BXM8; -.
DR EnsemblMetazoa; KNC24755; KNC24755; FF38_04850.
DR OMA; QLFEQMC; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR CDD; cd18070; DEXQc_SHPRH; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048686; SHPRH_helical_1st.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR45865:SF1; E3 UBIQUITIN-PROTEIN LIGASE SHPRH; 1.
DR PANTHER; PTHR45865; E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF21325; SHPRH_helical-1st; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00028; TPR; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 212..480
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 653..686
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1054..1097
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 1156..1308
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1319 AA; 153803 MW; 6EDDCFB70914999E CRC64;
MGDQIILTKI AKLANTQEIS CDNKNVTFEC KGKKWLLLDG YKDVAKNIFQ LIQKCGQHRP
KDFGFASTYD GYFVVVYRNI IRHKKDDFFD RLTEELFDTV YPYLKKPASS SSVMENKVLK
TYVTTRLFEA LQLKHKEVMR EDLTNATQRS LSLPSRFLPT LCEYQKKSIL WLLKRELDQE
SFPDFFEKLT AKDQETTVYK HLYSRYILAE PPDDLVLPPG GILADEMGLG KTVEMLALIL
LNSCLEINLC PAMEMFFSNT MAKRKCLDFK LFCICNSNSK LNTIQCQKCQ LWQHQDCVNF
FASDMDNEEV NTPYLCPSCW QLTVKEYGLL KTKATFIVSP NTIKMQWASE IKRHIQPTLK
VFIYEGVLSG KWISPRQLGD YDIVLTDYNI LRGDVYFTQD NVSERSTRNK PRSMRANTPI
LMLDWWRVLL DEAQMVESKT SKVASLVRMI PAIHRWAVTG TPIQNSLNDL QPLLQFIGFE
AASEPYVWQQ IVNEFVHQHE QQLENSNAIA PTCPAMIDIL QKCMWRTCKT QIASELNIPP
QEEIVHRIQF DNLEKLFYNE QHEECRNKFL ENVHKYSKRM TTISPQVMNI ILQPFLKIRQ
TCSIPVVVAT SNVNRNHNFN SQQQKQFLQP QELHDYLKST NEISCKSELR AMASSHNGLA
ALYFLQKKYD EAIKNYKAVL KLANDYSDMN IAVDSLLQIH ALHNLMQIKI IQSNISKINL
DKYEKQYNQL EWKYLSAYAS TLTTVKSGYE AALDKLSTDI SENFIITMAD GLETLSSSDE
SILLQKIHEE CLPKFGQTNV KLVEIQSSRS LLYVIQLWFN KLRDIWKTLQ TEIEDLKYFS
ENVRARNQVS PAIWRNIMQL VNSVYDCHLS EIREVQKSKK DLEKQKKTPK KKILCKLCCI
RNSMNAFECL LFDKVIDKES NDTEGLENPS FEMYLCKLTF HFVKNKHRIL TNIMEKCWLY
LENMQLFCKR LIKFWIEMEY TIKAYDELNM CKMRITLTDD PEDKSIFKIM ENEIEGRLLE
QQNELMNAQH QFTIKLARLR YIKHLEGNDD PGPCPICRLT EDDRYAVLEC GHHICFPCLK
SIRLYVKGSH FKCSICRNLQ QNQKIYYVSR SKSKSIDSET IIKGNYSSKI TYIVRLILKL
QREQIEAFQQ KQNDSNIEDE AKEINVKILI FSQWEPIIQA IALALNENNI KYRAQCTPKT
IEEFKNPNLG ITCLLMPFVR GSKGLNLVEA THVFLVEPIL NPGEELQAIG RVHRFGQHRQ
TTVHRFIVQE SIEEKIYNFI INSSSTSSDA TGLQRKWEFD NITLKDFENL FTLENRECD
//
