ID A0A0L0C1K2_LUCCU Unreviewed; 921 AA.
AC A0A0L0C1K2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=DNA mismatch repair protein spellchecker 1 {ECO:0000313|EMBL:KNC25309.1};
GN ORFNames=FF38_02564 {ECO:0000313|EMBL:KNC25309.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC25309.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC25309.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC25309.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC25309.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC25309.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JRES01001125; KNC25309.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0C1K2; -.
DR STRING; 7375.A0A0L0C1K2; -.
DR EnsemblMetazoa; KNC25309; KNC25309; FF38_02564.
DR EnsemblMetazoa; XM_046952896.1; XP_046808852.1; LOC111677682.
DR EnsemblMetazoa; XM_046956390.1; XP_046812346.1; LOC124421353.
DR OMA; LVRFPQK; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 743..759
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 921 AA; 104177 MW; 258ACABFE96E7FF7 CRC64;
MEAINANKQE PQLNLDTNAR RNFVKFLQKQ GEKPVTTVRF FDRTDSYSVH GPEDSDLISR
LVYKSTAYIR QLLADDGQPT PYVMLSKTNF ELAVRELLLV RNYRVEVYVR RSTGGEWQLE
YRGSPGNLLQ FEDILFSNKE ILVGNSILSL QLRVQNNQRN VGVASVDQND CLFQVLEFLD
DDFFTELEAT VVLLGPKECL LPQQDGEYEA VKNLLERNGI MVTVPPKSAN TEKNDLIQDL
NHLLRFAKGQ QEDATGMPEL QLNIAMEALR VAIKYTDLVN DAGNLGHYQI KQLNLKRFVH
LDAAAVSALN ILPKPGTHFS SPSYRWQSVL GVLDHCRTAQ GHRLMAQWVK QPLRSQEILN
DRHNIVQCFL ESPTTLNSLH EEFLKRIPDV LMLTKKLLRQ KANLQDIFRI YQVMLRTPKI
VNALLALENA TVKSVLCDPL KSYLEDLSGL KQMVEQVMDF DAIETGEYLV KASFDSELLE
MKERMSKLLH KMEKLQEKAG QELDLDKNQN VKLLNVSHVG YHFRITLRDD SVLRKNKNYK
IIDVVKGGIR FTSEKLTEIN DEFVTLRTRY EEQQKNIVEE IVKVAVGYAA PLTSLNNEFA
QLDCLVSFAI AAQTAPTPYI RPKILPEGAG ELVLKDIRHP CLELQEHITF IANNVEFRKD
KCNMFIITGP NMGGKSTYIR SVGTAVLMAH VGSFVPCSEA TISMVDSILG RVGASDNIIK
GLSTFMVEMI ETSGIIRSAT DKSLVIIDEL GRGTSTYEGC GIAWSIAEHL AKETKCFTLF
ATHFHEITNL ADTVKTVKNC HMAAVADNEN FTLLYQVRPG VMEKSFGIQV ARLANFPERV
VQNAQQVYNE FEDEHANKQS QEDKDLLDKI NKAIQDLSTT GNNKDINEKD LSQLVEQFTK
DIKKLDSEYF KAVLTTAVGE N
//
