ID A0A0L0C858_LUCCU Unreviewed; 1305 AA.
AC A0A0L0C858;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Glutamate receptor ionotropic, NMDA 2B {ECO:0008006|Google:ProtNLM};
GN ORFNames=FF38_04895 {ECO:0000313|EMBL:KNC28623.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC28623.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC28623.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC28623.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC28623.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC28623.1}.
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DR EMBL; JRES01000755; KNC28623.1; -; Genomic_DNA.
DR STRING; 7375.A0A0L0C858; -.
DR EnsemblMetazoa; KNC28623; KNC28623; FF38_04895.
DR OMA; DANCALM; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR CDD; cd13718; PBP2_iGluR_NMDA_Nr2; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF391; NMDA RECEPTOR 2, ISOFORM C; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 286..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 887..909
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 961..984
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1146..1171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 769..1126
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 773..831
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 1305 AA; 147590 MW; 0F660315DE86AC2A CRC64;
MKGFNLRQVK EGLNSRHKSK NCWSLKQQLP LSLRNETGGK TTIQKNLVSE IELQLKRQTF
KLNMAQPYER WKVEGGETKT TTAIKTSCKF NTKNTADFKC IKQTTINTFS SPRCHRYFHK
YKPNKSSGNK NSNSTCVNNT KHNLIRKSTD DPTTINTKTN TSTITTTSSN SNNYKSNNYN
YYYSTTKCLS PKKTHFLSLD KTTTATVRAK GKTIAATNTS NSSSAKSALI TTTNDKNSMI
YNNDSTSIPS TSSSYQTTLN LNNCSTKSTT TTATTTPPHI VAKSSIFYII LFLGFILLYS
CPATQAIRLA NSITKSSSAN KEQLYIGLIA PHTNFGKREY LRAIHTAVSG LNRTRGAKLT
FFKDYQFEPR NIRFDMMSLT PSPTAILSTL CKEFLQFNVS AILYMMNNEQ FGHSTASAQY
FLQLAGYLGI PVISWNADNS GLERRASQST LQLQLAPSIE HQSAAMLSIL ERYKWHQFSV
VTSQIAGHDD FVQAVRERVA EMQDHFKFTI LNSIVVTRTS DLMELVNSEA RVMLLYATQS
EAITILRAAE DLKLTGENYV WVVSQSVIEK KDAHPQFPVG MLGVHFDTSS AALMNEISNA
IKIYGYGVEA YVSDPANHGK KLNTQSLSCE DEGRGRWDNG ELFFKYLRNV SIDGDLNKPN
IEFTADGDLK SAELKIMNLR PGANNKNLVW EEIGVWKSWE TQKLDIRDIA WPGNSHAPPQ
GVPEKFHLKI TFLEEAPYIN LSPADPVSGK CLMDRGVLCR VAADHEMADI DVGQAHRNES
FYQCCSGFCI DLLEKFAEEL GFTYELVRVE DGKWGTLENG KWNGLIAELV NRKTDMVLTS
LMINTEREAV VDFSEPFMET GIAIVVAKRT GIISPTAFLE PFDTASWMLV GIVAIQAATF
MIFLFEWLSP SGYDMKLYLQ NTNVTPYRFS LFRTYWLVWA VLFQAAVHVD SPRGFTSRFM
TNVWALFAVV FLAIYTANLA AFMITREEFH EFSGLNDSRL VHPYSHKPSF KFGTIPYSHT
DSTINKYYKE MHYYMRQYNK SSVADGVAAV LNGNLDSFIY DGTVLDYLVA QDEDCRLMTV
GSWYAMTGYG LAFSRNSKYV QMFNKRLLEF RANGDLERLR RYWMTGTCRP GKQEHKSSDP
LALEQFLSAF LLLMAGILLA ALLLLLEHVY FKYIRKRIAK KDGGHCCALI SLSMGKSLTF
RGAVYEATEI LKKHRCNDPI CDTHLWKVKH ELDMTRLRVR QLEKTMDKHG IKAPQLRLAS
SSDLLNHHHL KERPPLMGNL SLAASAQDLY RWSYKTEIAE METVL
//
