ID A0A0L0CEI1_LUCCU Unreviewed; 177 AA.
AC A0A0L0CEI1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 {ECO:0000256|ARBA:ARBA00040793};
DE EC=3.1.7.2 {ECO:0000256|ARBA:ARBA00024387};
DE AltName: Full=Metazoan SpoT homolog 1 {ECO:0000256|ARBA:ARBA00041464};
DE AltName: Full=Penta-phosphate guanosine-3'-pyrophosphohydrolase {ECO:0000256|ARBA:ARBA00041770};
GN ORFNames=FF38_11716 {ECO:0000313|EMBL:KNC30661.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC30661.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC30661.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC30661.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC30661.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- FUNCTION: ppGpp hydrolyzing enzyme involved in starvation response.
CC {ECO:0000256|ARBA:ARBA00037781}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP +
CC H(+); Xref=Rhea:RHEA:14253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:58189, ChEBI:CHEBI:77828; EC=3.1.7.2;
CC Evidence={ECO:0000256|ARBA:ARBA00024273};
CC -!- SIMILARITY: Belongs to the MESH1 family.
CC {ECO:0000256|ARBA:ARBA00038354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC30661.1}.
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DR EMBL; JRES01000501; KNC30661.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CEI1; -.
DR STRING; 7375.A0A0L0CEI1; -.
DR EnsemblMetazoa; KNC30661; KNC30661; FF38_11716.
DR EnsemblMetazoa; XM_023453008.2; XP_023308776.1; LOC111690512.
DR EnsemblMetazoa; XM_046949739.1; XP_046805695.1; LOC111690512.
DR OMA; PPWRERK; -.
DR OrthoDB; 2783605at2759; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR PANTHER; PTHR46246; GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1; 1.
DR PANTHER; PTHR46246:SF1; GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1; 1.
DR Pfam; PF13328; HD_4; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:KNC30661.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 31..126
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 177 AA; 20565 MW; A5B1B13F539E171C CRC64;
MPPSNKFMEC LQFAAFKHRD QRRKNANQTP YINHPINVAT ILSVEGKIDD ESILMAALLH
DTVEDTDTTF GEIEELFGTE ICNIVREVTD DKTLEKQVRK QLQIEHAANA STKAKLVKLA
DKLDNLRDLE QILPNGWTEQ RREEYFIWAK KVVDNLRGTN KEIENELDEI FKKRQLL
//
