ID A0A0L0CFG7_LUCCU Unreviewed; 534 AA.
AC A0A0L0CFG7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=FF38_02246 {ECO:0000313|EMBL:KNC30985.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC30985.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC30985.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC30985.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC30985.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC PRP16 sub-subfamily. {ECO:0000256|ARBA:ARBA00038040}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC30985.1}.
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DR EMBL; JRES01000474; KNC30985.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CFG7; -.
DR STRING; 7375.A0A0L0CFG7; -.
DR EnsemblMetazoa; KNC30985; KNC30985; FF38_02246.
DR EnsemblMetazoa; XM_023441338.2; XP_023297106.2; LOC111679743.
DR OMA; QMGCTAE; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF91; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 33..216
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 508..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 60463 MW; 2F0BCBA97DD69F16 CRC64;
MDSTKFATFF GNVPTFTIPG RTFPVDVMFS KNTCEDYVDA AVKQALQIHL TPNEGDMLIF
MPGQEDIEVT CEVLAERLLE IENAPELSIL PIYSQLPSDL QAKIFQKSPE GLRKCVVATN
IAETSLTVDG IIYVIDSGYC KLKVYNPRIG MDALQIYPIS QANANQRSGR AGRTGPGQAY
RLYTQRQYKE DLLALTVPEI QRTNLANTVL LLKSLGVVDL LQFHFMDPPP QDNILNSLYQ
LWILGALDHT GALTPLGRQM AEFPLDPPQC QMLIVSCQME CSAEVLIIVS MLSVPSIFYR
PKGREEEADG VREKFQVPES DHLTYLNVYL QWKQNNYSSN WCNEHFIHVK AMRKVREVRQ
QLKDILIQQK LNVKSCGTDW DIIRKCICSA YFYQAARLKG IGEYVNLRTG MPCHLHPTSA
LYGLGTTPDY VVYHELVMTA KEYMQCATAV DGYWLAELGP MFFSVKETGR SGREKKKQAA
EHLKEMETQM RLAQEEIEER KIKAAQREEQ LANKQEIATP GVTTPRRTPG RIGL
//
