ID A0A0L0CQX0_LUCCU Unreviewed; 1906 AA.
AC A0A0L0CQX0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Polypeptide N-acetylgalactosaminyltransferase 8 {ECO:0000313|EMBL:KNC34646.1};
GN ORFNames=FF38_10180 {ECO:0000313|EMBL:KNC34646.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC34646.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC34646.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC34646.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC34646.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|ARBA:ARBA00005680}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|ARBA:ARBA00005771}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC34646.1}.
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DR EMBL; JRES01000039; KNC34646.1; -; Genomic_DNA.
DR STRING; 7375.A0A0L0CQX0; -.
DR EnsemblMetazoa; KNC34646; KNC34646; FF38_10180.
DR OMA; QECAWLL; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR CDD; cd02510; pp-GalNAc-T; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR045885; GalNAc-T.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR11783:SF180; GH11818P-RELATED; 1.
DR PANTHER; PTHR11783; SULFOTRANSFERASE SULT; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR Pfam; PF00685; Sulfotransfer_1; 4.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KNC34646.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 1763..1893
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
FT REGION 1305..1326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1906 AA; 225223 MW; 17F850214B5FC6B9 CRC64;
MVAAENILRS VEHVSEASKA RIPFPMKRYA TEGKNIPLKK NWSETWCTLS AHFETVCDQY
FNLELRKDDV FVVTFMKCGT TWMQECAWLL LNNLDYEKSK EEVVMIRSPF LDFHSIMPGL
LNHVELIEKL PSPRLIKSHL PANLLPLQVW EKKQKIIYVA RNAKDVIVSS FHFVKNLDMW
RGDNFHDYVD DFLNNEIIYT HFWSHIVDFW KMRDESFIFF VTYEEMKRDL ANVLQRLCLF
LERPQLSEKE MEGLLQHLSF DSMKKNKKTN LTDLLRDDNP AVKEEFQFMR RGIVGSFKDE
LTPELIAKID KWSGEFLAQH GLKEEDIFAD LLKTIEHVSE ASKTRLRPMK KYATEGKNIP
LKKNWSETWC TLSTHFETVC DQYLNLELRK DDVFVVTFMK CGTTWMQECA WLLLNDLDYE
KSKEEVVMIR SPFLDFHSIT PGLRNHVELI EKLPSPRLIK SHLPANLLPL QIWEKKQKII
YVARNVKDVI VSCYHFVKNL QMWQGDNFHE FVEDFLNNDI IYTHFWSHIV DFWKMRNESF
IFFVTYEEMK RDLPKVLQRL CVFLERPQLS EKEMEGLLEH LSFDSMRNNK KTNLTYLLKD
GNPAVKEEFQ MVHQNILKSL EHKSEATKAR LPYPVKIYST EGKNIPLKKN WSQTWCTLPA
HFDKVFDEIL NFELRKDDVF VVTFMKCGTT WMQECAWLLL NNLDFEKSKE AAVMIRSPFI
DFHGIVPDTP SPIEMCKQLS SPRLIKTHMP ANLVPLQIWE RKQKMIYVAR NVKDVIVSSY
HFIKNLDLWR GNSFQEYVED FLNNEILYTH FWSHIVDFWK MRNEPFIFFV TYEEMKRDLA
GVLQRLCTFL ERPQLTQEQL LKTVEHLSFG SMKKNKFTNL TYLLKENMPG VKEDFQFMRR
GIVGSFKDEL TPELIARIDK WTADFLGKQG LKEEDIFGKL LINVRRNLGS YENSESNICI
SQMVFRKNVL LSRAITSEAS KARLPYPMKQ YATEGKNIPL KKNWSETWCT LPENFDKVFD
EILNFELRKD DVFVVTFMKC GTTWMQECAW LLLNNLDFEK SKEAAVMIRS PFIDFHGIVP
GTASPIEMCK KLSSPRLIKT HMPANLVPLQ IWEKKQKMIY VARNVKDVIV SSFHFVKNLD
MWRGDNFHDY VDDFLNNEII YTHFWAHIVD FWKMRNESFI FFVTYEEMKR DLAGVLQRLC
TFLERPQLTT EELEKTIKHL SFGNMKENKQ TNLTYLLKDN MPGVKQDFQF MRRGIVGSFK
DELTPELIAK IDKWTADFLD DINKQLRDWH NYSHTRLQLQ QVITTTRDHS QQSSNNSNKQ
IQQQQQNFYA PKSKYKKKLQ SRQPQDKILN ADNFGQIAIT NSTYNLKLIE NKQFKHANNN
KQKEKNNDNS NKYDYYKKRS QLTGFNVELS ESLPLQRLIP DTRHKSTNSV KFYFFSSCKT
ELYPADLPSC SIIIIYHNEQ ATVLLRTLYT IINQTPDELL KEIILVDDFS EPNKEIDRHI
ESQFPELVKI IHLSQREGLI RARLKGAKEA LGDVLVFLDA HVEVNENWLP PLLAPIVEDE
KTCTTPIIDI IKYDTLEYQG SMPSRGGFNW QFNYVQLPLL REEKTLQPQP HNNPIMNGGL
FAISQKYFWL LGGYDDGLEI WGAEQFELSF KIWLCGGRLL EVPCSRVGHL YRDPEFRVNY
TSRKDDFISK NYKRVAEVWM DEYKEFLYEH IPKLNLIDAG DLKQQKLLRK QLKCKPFKWF
LKNIAPDLLK AYPPVKPTDF ALGAIQSLAV PKLCLDLDSV ERRQILKDVL KPCSPDLKYP
YASQRFHLSF RHDLRHQENC LEVQTWSSHA PIWLWPCHNL GGNQYWYYDR NTQMFVQGKT
DFNQRCLDMD RDSLKIFVSY CDFGRQEQKW LIGYVNQTAM DHFFEE
//
