ID A0A0L0CVY4_PLAFA Unreviewed; 1336 AA.
AC A0A0L0CVY4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 22-FEB-2023, entry version 26.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=PFLG_01160 {ECO:0000313|EMBL:KNC36417.1};
OS Plasmodium falciparum RAJ116.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580058 {ECO:0000313|EMBL:KNC36417.1, ECO:0000313|Proteomes:UP000054566};
RN [1] {ECO:0000313|Proteomes:UP000054566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum RAJ116.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum RAJ116.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677}.
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DR EMBL; GG664123; KNC36417.1; -; Genomic_DNA.
DR EnsemblProtists; KNC36417; KNC36417; PFLG_01160.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000054566; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000054566}.
FT DOMAIN 1185..1201
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 911..938
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..579
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1336 AA; 154706 MW; BD05712ACE830525 CRC64;
MASSNKKQSS ILSFFKSNEE KTNKSSCLNE INNKVGDGKG HKQNEINNNV PEKRKSGDDK
SGVDSKNKNE KENLGSNKKI NMLDMFLSKG EMYNKPKIID NINKEPINGD MLSTDKNMNV
NKTNKMHNLF LDEEKTDMSK TKCSNDNVYD NNVYNNNVYD NNVHNNNVHN NNVRNNNVHN
NNIHNNNNYG NIYRNDNCVV KSNECNNNGV ELDEDSNYQN MVHNQMLEGR NYMDNLESST
EDDIIIKKKR KIILDSVSDK ECSDAKENNI NKNNCSVDNK LTNLLYEPNK EIDDNLLLLD
DNNNNNIKKC IEKRKGDDSK KSQELDGLRN KYLNLPISIT NDKFRLYIEH YFLYCNTFEF
PKWIQPQYIR DINLRTPDHA DYDSSTIWTP PPDHKWAIEY KQAHYTPGMQ QFWKIKSRNF
DKIIFFKMGR FYEIFYIDAC LMHTICSLNW MSGEHKPHLG FPEQSLHFYA KKVINSGHKV
VVIEQMETPK ELEQRNKESI GPKDKAIKRE INEIYTKGTI LHDNMLSAET KYLVCFYFDE
IENMTNVNNN IKDNDDDHNN IKDNDDDHNN IKDNNDDHNN IKDNNNYTFS QYDNKNKCNF
GFVVSDIATS YIAVGYCNDD ESRIVLRTIL AQLCPAEILY SSKNINKEVL SIFKNIPTSP
ELTCLNSFPN IISSFDEINK YFENMPSNLE IYKEQTSVIC AFGGFIFCKI EKYDLFKREN
YMVLDATALK HLEILETQSG DTKNSLYDYV NKTCTNFGAR NLRRWICSPL LDCEKIRERL
DVVDFLKNNE QILSLIRMKL KKLPDIERLL NKICIQASQS ERGAVFFDNV VNTKLKEFVT
FLNAFKEIDT MLIDVNRIER DGELPSRLFQ ICNTPDICKD NIKGSYPNIG LITNEFLEKI
YFDGDKEYKP AEGCDEDIDK INEKEKNVEN KLNNVLEHMR TQLKIPTLKF VHAKFKYEVE
CPDNIPKSFL KNVEITSAKK GYVRIHNDEI KSLVEKLEDI EQEKKDAIYP FFQKLFHLFY
AHYEKYVSAC RLVAELDCLQ SFAYVVLNTA FPLTRPILHP MDSKQGEEKT PFLILEDNIH
PVVAMLMPNF ISNNIYMGCD KEKQSTLLLT GPNMGGKSTL LRQTAISVIL AQIGAFVPCT
YCELTVVDKI FTRLGSSDNL FEGKSTFLVE LEDISNLLKQ STKYSLAILD ELGRGTSSFD
GTAIALSTLE QISDVIKCRC IFSTHYHLLV EEVKHNKNIS NYHMSLSIDD EQEKIIFLYK
FIKGVCPKSF GIHIAKLAGL PKEIIDLAHE KSLLFENVTD EFCKIIKYKN ITRSLLNEEA
DEKLVTLFHK YKKEFA
//
