ID   A0A0L0CW58_PLAFA        Unreviewed;       979 AA.
AC   A0A0L0CW58;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Dynein heavy chain linker domain-containing protein {ECO:0000259|Pfam:PF08393};
DE   Flags: Fragment;
GN   ORFNames=PFLG_01777 {ECO:0000313|EMBL:KNC36451.1};
OS   Plasmodium falciparum RAJ116.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=580058 {ECO:0000313|EMBL:KNC36451.1, ECO:0000313|Proteomes:UP000054566};
RN   [1] {ECO:0000313|Proteomes:UP000054566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG   The Broad Institute Genome Sequencing Platform;
RA   Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA   Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA   Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA   Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "Annotation of Plasmodium falciparum RAJ116.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000054566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG   The Broad Institute Genome Sequencing Platform;
RA   Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA   Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA   Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA   Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA   White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT   "The genome sequence of Plasmodium falciparum RAJ116.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG664138; KNC36451.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L0CW58; -.
DR   EnsemblProtists; KNC36451; KNC36451; PFLG_01777.
DR   OrthoDB; 248240at2759; -.
DR   Proteomes; UP000054566; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR040163; RP1/RP1L1.
DR   PANTHER; PTHR23005:SF5; NUP637, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR23005; RETINITIS PIGMENTOSA 1 PROTEIN; 1.
DR   Pfam; PF08393; DHC_N2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054566};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        587..606
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          234..533
FT                   /note="Dynein heavy chain linker"
FT                   /evidence="ECO:0000259|Pfam:PF08393"
FT   REGION          145..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..164
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..235
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         979
FT                   /evidence="ECO:0000313|EMBL:KNC36451.1"
SQ   SEQUENCE   979 AA;  118525 MW;  FD8C67B786D54C49 CRC64;
     MFINNSLTIY TFFQYINLNE KYRHQKIFYL NIPQFCNDIN NINIFFKKIN KNFVNNEIYD
     KCKKFNMTYE HIIKLLKYLQ PIYTNQKYFR RAIDLLNHSY DMDNHVLENI NDMYTIRSSQ
     EKNKNGHETQ ISQGINKNIP QGLLQMDHTH KNGDTHKNDE AHQNGETHQN GGTHQNDEAH
     QNDEAHQNDE AHQNDEAHQN DEAHQNDEAH QNNETHQKHN HIDKDQYEKQ NSRRHIQKKE
     KTFLSYNYEM IILENLFGLP FSSFLTNVEK ICFEYEKEKR INDRFDRIRT SLKKYKLDVS
     LINKKVYFIN NINELITYIK KIMDELFFIQ NDKYSKHIYN EIYKLSKQLL NFKNTLVVIK
     KIQTYYINTL QKYKNNEIKK CTNDSEYFSS LINTYKYHCE EFFIYPQINK HLEKNYDIQY
     FYNLLKQLEE LITTVNLYIL NKRKEFFSFY LLNDENFLNI YLNIKDIKTL NKYIQHIIPS
     IKKLIYQNEI ICGVLSKDNQ RIIFKEQIKY KKLEFLLNQI NLEIKNWVLK NIQNVLQNEI
     IQKKDINYIN NDDNNKNNKD NKKFESSLSF YPLKEDTYLI FLKITNMQIL FIILNIYFTY
     IMDIFIKNVQ KNKYIIYILS QNVIHLVQKI YNTNLYLENE DDNVSVDNIL TNEQKTLNHI
     NIINNNNNNN NNKNNNDDIY NNNDDIYNNN DDIYNNNNHI YNNNNNGVYI NKHLIFILLF
     FMNMKQKLLS ILNNDHSKNI SLNHFNYLEI DKHYFKNNDY IIEFFHHNIK YKYELLNNYN
     YTLDIIYHEK KYSFLLYKYL SNHFITLYSN NSYSINYTKN FSILLGFHYF LINNINLNKN
     DILNFISCSV SSNVSLFFYK VDKYKPHILS ILNKQLSIIN YHLQNKKKQI IINNQELNLN
     KRNLIYLSIS KDYSPPISLY FSNNHNNINS KFNFSYTIYQ SSKPFPLSIF YLIYFSFGYL
     NPDLLSQATY KTYLYLKKH
//