ID A0A0L0CWX0_PLAFA Unreviewed; 401 AA.
AC A0A0L0CWX0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 22-FEB-2023, entry version 24.
DE SubName: Full=Aminomethyltransferase {ECO:0000313|EMBL:KNC36721.1};
GN ORFNames=PFLG_01976 {ECO:0000313|EMBL:KNC36721.1};
OS Plasmodium falciparum RAJ116.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580058 {ECO:0000313|EMBL:KNC36721.1, ECO:0000313|Proteomes:UP000054566};
RN [1] {ECO:0000313|Proteomes:UP000054566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum RAJ116.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum RAJ116.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR EMBL; GG664236; KNC36721.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CWX0; -.
DR EnsemblProtists; KNC36721; KNC36721; PFLG_01976.
DR OrthoDB; 5473523at2759; -.
DR Proteomes; UP000054566; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 4.10.1250.10; Aminomethyltransferase fragment; 1.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR PIRSF; PIRSF006487; GcvT; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:KNC36721.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054566};
KW Transferase {ECO:0000313|EMBL:KNC36721.1}.
FT DOMAIN 28..286
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 315..394
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 401 AA; 46225 MW; FA70D6BF4B369974 CRC64;
MGHFPTLSYN KKNNNITQYF VEIKKTILYD SHKKNNAIFK IQHGFYLPDE YKDITLITSN
LHTRTNCSLF DYTYRPILKI SGEDKINFIE KYVGSDIKGL WENECRISLL LNDKGGIIDD
IMIILREKYL LLYLNIQCKE KVYKYLKDKL LENGKLQVQI EEFTSHSSIC IQGSKSSDVL
KELIDYNNES VETNLDNCSF MSSTLTKINK IDNCILNRYT CTGEDGFDIL IPNKYVNDLY
NLILKNELVK PGGLAVQNTL RLESGFCEYG KDINEDITPI ESNYKWSLGQ RRLKELNFNG
AHIIMDQIKN GTKIKRVGIL INTNIVPKEN TKIYSHENAE QIIGYITSSV FSPVLQKPIC
MGYVKSEYAH INNLIKVDCL NKLEIAQITK LPFVPLSIYK L
//
