ID   A0A0L0D2F6_THETB        Unreviewed;       821 AA.
AC   A0A0L0D2F6;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN   ORFNames=AMSG_02787 {ECO:0000313|EMBL:KNC46335.1};
OS   Thecamonas trahens ATCC 50062.
OC   Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX   NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC46335.1, ECO:0000313|Proteomes:UP000054408};
RN   [1] {ECO:0000313|EMBL:KNC46335.1, ECO:0000313|Proteomes:UP000054408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC46335.1,
RC   ECO:0000313|Proteomes:UP000054408};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA   Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA   Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA   Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA   Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA   Ruiz-Trillo I., Lander E., Nusbaum C.;
RT   "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; GL349442; KNC46335.1; -; Genomic_DNA.
DR   RefSeq; XP_013760628.1; XM_013905174.1.
DR   AlphaFoldDB; A0A0L0D2F6; -.
DR   EnsemblProtists; KNC46335; KNC46335; AMSG_02787.
DR   GeneID; 25562439; -.
DR   eggNOG; ENOG502SD42; Eukaryota.
DR   OMA; MNTWINA; -.
DR   OrthoDB; 5483476at2759; -.
DR   Proteomes; UP000054408; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd00821; PH; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   PANTHER; PTHR14336:SF8; DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE; 1.
DR   PANTHER; PTHR14336; TANDEM PH DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF00169; PH; 3.
DR   SMART; SM00233; PH; 3.
DR   SUPFAM; SSF50729; PH domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 3.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054408}.
FT   DOMAIN          96..195
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          451..551
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          608..706
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          33..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          750..821
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        756..774
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        799..813
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   821 AA;  88590 MW;  794E25A795B790E7 CRC64;
     MVSEAEDPEW LVGSLDGARG RLVRPAPATI ANASRISDLG ATTRTEPVEP RESPSSRSRA
     VSTDFDRAAA ASVIGARDPG APARASPARK RSAASRIRRM GYLLKRGARF KSWRRRWFVL
     QGGVIYYFSS EHAFDSDERA LGLIPVAVYA HIEVCAVPDG FGFALVLPGA RTYYLAAATR
     DERTLWIDDL LALGLTVLDH GVGFSRRPTL LSGASAGSGS AAAPEPQHMM SHGVLARTRF
     AYDGTGVFVS PTELQAARTS DAPHDSASFI SGPDTMPCAL SFSVGRLITN VEISTDSRYG
     YGRLDDEVGF FPLAAVTIIS SPIEAQDGPA ARDERRTSSS AGPAPGAAGD DAEDEPVLEA
     NGERPEIDVC KSYLDEGWVS AEVFRMVSDQ VAVALGPGAE SSDPAQHESM YEAGLVAWDT
     AVRTLRAEAN PLIDSSRACT LTPDEVAAID GLARIGVLSK CGGRVKSWRK RFFVMQELTL
     YYFRSEEAWR DGAEPQGSIP VAEYEQVGLL ADNEMVNGFM ITRCDSRTYF LAALTPVDRD
     AWVHAFQIIG LKLVSPGRLH LAEASDLDSD GEAAAPAPSP ARSRGSSIWR SDASYKRKNT
     GRRRSVSLQN RVGWLYKRGG MRKNWKRRYF VLQEGELAYY EAKVLVRPLK VINLREYYEV
     DFAESESKRA RFGFKITGDG LRTFVFAAAT EEIRAQWVMA FHQVGLVRAY SVVNSPNPLY
     AVRARSVSLH EPARKLSDVA EVAAPSAAAA ISGVRPGRSA TTSSRPSSLA SGGSGDLSHA
     DHVHADDGDD ASEVSSSSST DEPDDDLDAG EPDDSDSSSG Q
//