ID A0A0L0D3D3_THETB Unreviewed; 773 AA.
AC A0A0L0D3D3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=EH domain-containing protein {ECO:0000259|PROSITE:PS50031};
GN ORFNames=AMSG_03127 {ECO:0000313|EMBL:KNC46690.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC46690.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC46690.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC46690.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; GL349443; KNC46690.1; -; Genomic_DNA.
DR RefSeq; XP_013760458.1; XM_013905004.1.
DR AlphaFoldDB; A0A0L0D3D3; -.
DR STRING; 461836.A0A0L0D3D3; -.
DR EnsemblProtists; KNC46690; KNC46690; AMSG_03127.
DR GeneID; 25562757; -.
DR eggNOG; KOG2528; Eukaryota.
DR OrthoDB; 5475877at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR46571; SORTING NEXIN-8; 1.
DR PANTHER; PTHR46571:SF1; SORTING NEXIN-8; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50031; EH; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 137..236
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT REGION 111..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..276
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 773 AA; 85795 MW; D53A123DEC0A1031 CRC64;
MASSGPGGRF YPSSKYHHAY VALLESVGGS ESKSLSPSAP VAELEKAATA MAEVGKLLDD
VSSLSRSDMR ALWKEAAAAE SIPARRFVLA LRLIALAQAG DEASLHRLDD IERSRRGDGP
DDPFFSDEES DPELGRHSAA YQALFDDMAG TDGTVSNRAL GKYFLDVANV SKARLKKLWA
ASDTKGDGIN DRSRFFTLLR LIALEQRSPP ASLSTLRKHS RPGDIPLPRL NGEERSRSRS
RSRSRSRSRS RSARRDRGRS RSRSRSRSRS RSRSRSHSRT RLDDVISRSR ERATRRTELI
FSVDYEDEYD DLFESVTSRG RVDADLFTDL LKSTGITRGT LAQVWREAGC SRLNRRSVVN
ALKLCSLSQQ GREPDMDELD RVGAEKVPPP EFDGGASSSA MAASREGARA RVYGHNLPDE
STYKAVFAPD DVKVEVQQLQ AGKLKKHTVY SLTVKSKAHT QLLTIFPYRI VPMLPKKKAM
GKFEEEFVAE RCRRLEVFME LVLRRPIFQQ GEGAPLMRLF LCELDTKRFE KQRKLFKVMD
TEKDFHPCRQ TGSSFVADDA DTALSAAESE VAILASNVEA QLNALTDIVD HRNGLAAGFA
ALGGALSSRA TQRTDFDSIP FNSSLSTTAG MLGELTTALT DHAQDELTRV LDAVWKHYQL
CIGLLKAFEA ARAPMKDKAN VNARLETNKA KLASMEARGK TGPQKLRSAI TNDSMAVIDL
GVAVEFARYS LAQEMYYFHD MHEIWGGEVA TAFDDVERKW SGAQADIWRE SSS
//
