ID A0A0L0DI77_THETB Unreviewed; 951 AA.
AC A0A0L0DI77;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN ORFNames=AMSG_06987 {ECO:0000313|EMBL:KNC51013.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC51013.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC51013.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC51013.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR EMBL; GL349464; KNC51013.1; -; Genomic_DNA.
DR RefSeq; XP_013756481.1; XM_013901027.1.
DR AlphaFoldDB; A0A0L0DI77; -.
DR STRING; 461836.A0A0L0DI77; -.
DR EnsemblProtists; KNC51013; KNC51013; AMSG_06987.
DR GeneID; 25566031; -.
DR eggNOG; KOG1959; Eukaryota.
DR OMA; LEFIWRP; -.
DR OrthoDB; 5474711at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10810; GH38N_AMII_LAM_like; 1.
DR Gene3D; 2.60.40.1360; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT DOMAIN 295..367
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
FT REGION 911..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 103334 MW; 5415E39E76413A30 CRC64;
MICHTHDDVG WLKTVDEYYM GANSSIQLAG VQYILDSVMP ALEAKPERKF IYVEQAFFRI
WWSQQDAAMK ARVRKLVADG QLTFVEGGDV MPDEANPTFS DWVDALTRGQ RFLLDEFGPE
ASVASSQVLW QIDPFGHSRT VALAAALGGA NIGVLGRIDY QDMAHRESTK RMEFVWKTSP
SLASMGPTAD LFTLKTFNGY GPPDGFCFDV VCDAPPIQAD PLLEDVNIKE RADAFVAAAK
NWASVYTSNN VMMTMGSDFQ YQAANMWFKN LDLLMGYIQD NAAAYGVDIF YSTPQNYAAP
ALKRYVRSNS AYLRLSRQLE AAAMAASPSG PVGSTDGLWD AVSVLQHHDA VAGTEKQHVA
NDYAKQLYIG HAHADALTSD ALARLTERSY SGLVFDQCRQ ANVSICAATQ GVPARDGPGV
VVVLYNQLAT ATSVWHRLPV DSTEWAVVNA TSAPVPAQIV VNPPPLPGRP TASKYTLVFH
AADLPPMGYA TFFLVPASSA APAATLAARA DGPPNPVGNA HFELTFRSDG LLAAYTDKAR
GRTTKLVQRL AYYNASAGGE QPHPPVLNEF QASGAYIFRP NSSALFSTGH AAGADISVQN
GPFGVEILQR FSDWAYQQIF VYAGELAPTV EYTIGPVPIA DADGKEVVTV FASELDSGAN
WHSDANAREM IARRRNYRAT WQLNCTQAIA CNYVPVNTAM YLEDDAARLT LVTDRSNGGS
SMASGELELM IHRRLLFDDA RGVGEALNET GITGNGLIIR ARHMFHVGSP ESGADFQRPA
VARITYEPTA FFAPLTGTPA EWAVAHRTAW SGLSAPFPPN VFLQTLQLLD PTTVLLRLSH
RYALGESAKW SRPATVNTTG LFTAFSITAW TELALTANQP VANLRSRFVW NSSGGPEAAV
ASPLHSAVNR ASPFRPSPHR PDRGYGTGPS VELLPMETRT FELVVEWKHE A
//
