ID A0A0L0DIL6_THETB Unreviewed; 3179 AA.
AC A0A0L0DIL6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=HECT domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMSG_00953 {ECO:0000313|EMBL:KNC52127.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC52127.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC52127.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC52127.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL349436; KNC52127.1; -; Genomic_DNA.
DR RefSeq; XP_013762131.1; XM_013906677.1.
DR STRING; 461836.A0A0L0DIL6; -.
DR EnsemblProtists; KNC52127; KNC52127; AMSG_00953.
DR GeneID; 25560728; -.
DR eggNOG; KOG3533; Eukaryota.
DR OrthoDB; 5480299at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 2760..2779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2791..2814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2858..2884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2904..2928
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2980..3003
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 669..792
FT /note="RIH"
FT /evidence="ECO:0000259|Pfam:PF01365"
FT DOMAIN 2208..2299
FT /note="RyR/IP3R Homology associated"
FT /evidence="ECO:0000259|Pfam:PF08454"
FT DOMAIN 2844..3013
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 229..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1058..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1445..1492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2421..2458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2470..2494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2516..2553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1445..1463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3179 AA; 346679 MW; 5C78DEBDDB862111 CRC64;
MDGDHALRFD DVVVLHLHNS DTSSAGLGLN TSTASAEPET AGVLSASVVD ADAPYLDPRA
DPDSFEYAHL FRIRASLRFG ALHAWLAARD RGGSDRAGVN MALLYENMRY EAQFNAGEMD
RTAGRPLRYG TPIQLQHVLS GKFIGRQGAS YELVLVDEAH AASVFTLASK YRIRQDDDLV
FVGDPIGLYN NLGQWLNADT DSALNLHGMV SLRVGGGFAF WHPRLFSTTP PSTSHDDSRL
ASAPLSSTST RSDRQTPFSL RAIDEAGAEA HGHASSGDPH LTLGNVVQLY NIEHEGFLAV
EAFLDSGSEL VCVHAHPSPS SKASADVTLN ANTLWLLELV EPFSRPVLLA SNGRICYRLR
HLRSGSYLAI ADDEPIDLEN DGATLHWLFR DERAFPDLVT AVTDPTDAGD AAIFFIDRIA
DAAAPLRLDD ADLLDFGNRV LLRHASSGSV LATMTRAVHQ MRENDVMFPN TAAASTAAAA
AAGAAASARA RAAVMAAVRG AATLGISDPT SARVSAAVAS RILRYPLQPS PFKRSSRALV
NSFQLRAVPE LLFRLAALLS AVRAAQADYL ALWRNQDFLP TPRQLRPLWI ALRSLVSILR
EPQRLVHQGS RIGPISSATT DSALREAGFS SLAHLRQQIQ RFVGEFGIIR LALDMLSAPF
TELAPTTSVI TTSRLANSLL IHAVKDNIYN AALVFPMFDA LIALLGYDLN TAATLAHVFD
RNELLLHAIS PDHVTRFVAL LDKRSASPDS RFVLRRYLRL LSSITVFNGR GVLANQELVT
NSLVVNAPHL LIRFTQPGGG RPALAWLGDT SISLTELDTR ADFAPQREYL VAQLELLANL
VHSRSHFIST VVQTVVPFPL VFSVVSSPDY SYPLRAAFLR VLHHAYVDVD PFHAIPLLQP
IHIWSSLALD ATDDSGTGSS AASESLSEAG GESAAPPATR FSATGAWASY ARQGRDRIER
NPQLKAVETM VLRQLGAIGA AYGAENHPFN TSGYKTSAAG IDAYSPSSVD EAGFTTFVLA
MLMLLHLMLK FGLFRDHTHR LHLVQALLPL LERATAQSSD ETHSSADAAD SPSAEFSDVD
SYASSATTSS PSHRSAYDVV GSCDPVAVPD ADDHEVGVSA DLFDIAFDHS QILDSHGTVG
SSETAWSFVR QAILVLFDAV HELEVSASLS GLLTLLHTAV RPYISRLTRV FQSSIRPTMT
HAASTASLTL HDMANSGVAT AISPTIALLR ATLEELPRLA DLLDEVHIRS SGFFDQSPLL
ALLTEPATTN ALFGIVLNAS STPLVTQAFG LLTSSRTHVL SVLRAAETTQ IIALRQNRES
FTRIANLKFE LEELLTSTWC LDVANRVLYL LETAASMLDP SSPLCFSHKQ NLMLFHHFRI
LPLIMQVVAL TLASRALSAK LRAEAVESAA RSMILDVDSP LVRDAPVPVP PRDDSYSYIE
TYELDTEASE QQASSSGLTS LSYSEYDDDD GESYEYAPPS PGDNSSDSLP SELGDSIAMR
VEPDDIALPA PLADLTPASL ATTLDTIETQ LLISALELIP AYCAGSPAAQ QLLVGYVELI
MSVVAKEARP ELEHTRVAVD TAAVEALASI FRNNFGLASE LDAVVIQAFV AFAGSEGTRA
PRYLRFLREL TVVVTGQSVS ALKRNQILIL NTLSMMPPQS WLVVYDGPCD IAPELIDDPE
SSFHYHVELI HLLAACARGK HHLAEVICQA LIRPEQVAAA ISDEDAPPQL RAAYMALFHH
AFVDTTQAAP LDATVLVLSH VRTLIAASCT LDATNPHSLV HRTMVAAVFG TALPLVYAFF
IRAWSSSRDV GPVTKHLPLL RTLTKLALFV IDLGDEFESS GAVRDHMEEL VLGVLRALAR
NAIVDAGSAH VIHDADRTDA VLARKPNWSA RLFQGLGLFD TDSRTAELVE RNFVEDAIAA
YRSQLVDLVV GMTASETEST PAWLRRLRWL RRRRRGRKFL PTPVPALTSA PGAQLAGEQL
GNVVNSGVGS PSLHMKPWTL LIELLCSKTK RPVILRLIEL LDEFESRGLV LAARNVVQVL
IDALAFERQS GEAAAERPLR DAFVAAGVIQ KAVQVLGTAH SLLVEPTLWL VIRLLEGGKR
SVQDAFYDVV SSPSTSFFKV LSRIIRSAAR TLEEVSSASD SVAGLGADSG VGAHTATPVP
AVDADHATGI LHSIAQSDKV TRNAAIVGAA DRTCPHPQAA TSAHTLVGHV VVLVQWMVAN
QHSGLQNLLR DQPGATQPTN VVRDLISFFT LYVAFLRPNN LLLATQLLHT FAELCMGPCS
GNQEIISVTR LCKVVNEVLS TDTLALVMSS SFFASAGRDD ANNADAPDDG TASAVLSLPD
VDEALLPVFA ASPHFLAGLG QIRMAMAAAA ADELASTASP EHGMTRAEAE ADAERYHAVQ
TGVGRGGDGE PGEAVFVDVG ISAFRPQPQN ETLESSPVTG ERRGEAGHAS ASDGDGSGCA
VWSAVKRLRA GKASSGESLR ELGLDPDSRR PRDPRYAHLN IAAGDNGMAL FVVDDDEERG
GGDDEDDQVD EYNGDRRGTP GSTRVKEAPA ERRRRQATHV YLAQLRLAAL DTLHALLEGS
TVPSWNVAVH RRMIDQLNLV RFADTAAATA KLSLSSRRVW GGGRRIKLWE RLKSLRAREG
FQAYILLAKL MDLEPQSRRV LEALRTHDLS AYVALRGRVE YVNADRELER LYFRIPDHCF
NLTKERWDRF VLDIDRDDEK LKDFMVKSED LSFELKTKSV QPLGAIGRYI QQRDLWWKDM
SFWTAVVINI LMIAFWRTSS GGEISYIADS VRGVIVALGV VTLVTSGLTT MAYLMSLGPL
ILYKSWKSEE PVVEFDERER NVWFVLKSTL FLLRNSRCLF YVAYFVTALL GLAVSPFYFS
FHLLDIVNRS ATLRSVIQSV TLNLASIVFT GVLGMLGIYY YAIVGFNLMR DDFVLEGSRY
CDSLALCIVT VANLGLRASG GIGDNMVLQP YSVDHSLARV AFDLSYFFFL VVIFLSIFLG
IITDTFGELR ARRNYLQNEI RNHCFVCGVD RSRLMRDGNG FSTHVSSEHN IRHYMFLISY
LRELPLLQQS GGEAYIARKI LVYDTSFFPE QRAMCFERSA QRDTVELWEL AAKVDDVRND
HDRMLAEVRR YCAALEQAQL RAKREQDTDL EILLAELRVQ QDMTRVLATR IESALAGSE
//
