ID A0A0L0DKR7_THETB Unreviewed; 847 AA.
AC A0A0L0DKR7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=AMSG_09067 {ECO:0000313|EMBL:KNC52902.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC52902.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC52902.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC52902.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL349476; KNC52902.1; -; Genomic_DNA.
DR RefSeq; XP_013754996.1; XM_013899542.1.
DR AlphaFoldDB; A0A0L0DKR7; -.
DR STRING; 461836.A0A0L0DKR7; -.
DR EnsemblProtists; KNC52902; KNC52902; AMSG_09067.
DR GeneID; 25567604; -.
DR eggNOG; KOG2189; Eukaryota.
DR OMA; FYLWFFL; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 453..478
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 499..516
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 574..594
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 606..629
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 663..682
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 787..806
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
SQ SEQUENCE 847 AA; 92463 MW; 56D3B078311FE8D2 CRC64;
MGSLFRSEEM HLIEMVVQAE AAHATVEELG RTGVVQFVDL NPELNAFQRS YVNDVKRCDE
LERKLRFFKE QVEKAGLPIA PKTEAGAAAT EASSLVQGAR RGRRYGGAGA GMAAPADAGG
ANLDDLEEHF VELEAGLVQL NANQEILDSA ANELTELQCL LAQTSVFFDD AGAAGDVFVS
QTSALDANGP SASSPLLGTG GRLGESAPGA GTASSRAVQL GYVSGLLEQT KMARFERLLW
RATRGNHILR QCTEAVELSD PASGEPVSKI AFIVFFQGAR LRTKITKMCE SYGANLYETP
DTASARQQLL VEVEARMDDL ELTLDSAAEQ RERVLSVIAA SLEDWLDIVN REQRIYHALN
LWKSDVSSRA LVARAWAPVW GDSQIEAALA RGVARSGASV QSFFEVKVTS SPPPTYFVTN
KYTAGFQALM DAYGMARYQE ANAGVFTIIT FPFLFAVMFG DLGHGALLTM FAAILVAYEG
RIARIPGRPE MFNMLFNGRY LILAMGVFAM YAGLLYNDCF GFSIDFFGSN WSRPSDGDAH
LIDPDRVYPF GVDPGWAGAT NKLQFYNSFK MKTAIIYGVT QMLFGVVLSL TNHLYYGNYI
DVWTRFIPEV LFLGGMFGYM VILIIYKWVT VIPDPPLILT VMIDMFLKAG SVPAKDEMYS
GQGAVQIILV FVLLVAIPWL LLPKPIILWM RKKAAARRAG HSHGGATEAL LAPAADGTEP
EGDGHGHDMG EIVIHQIIHT IEYVLGTVSN TASYLRLWAL SLAHAELSEV ILDQVLFRGL
KAGSAPLIFA AFTVWALATV GILMIMESLS AFLHALRLHW VEFLSKFGAS DGWKFEPFNL
DAPVAAE
//
