ID A0A0L0DL19_THETB Unreviewed; 982 AA.
AC A0A0L0DL19;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA ligase IV {ECO:0000256|ARBA:ARBA00031942};
DE AltName: Full=Polydeoxyribonucleotide synthase [ATP] 4 {ECO:0000256|ARBA:ARBA00030676};
GN ORFNames=AMSG_09125 {ECO:0000313|EMBL:KNC52955.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC52955.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC52955.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC52955.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC {ECO:0000256|ARBA:ARBA00007572}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL349477; KNC52955.1; -; Genomic_DNA.
DR RefSeq; XP_013754848.1; XM_013899394.1.
DR AlphaFoldDB; A0A0L0DL19; -.
DR STRING; 461836.A0A0L0DL19; -.
DR EnsemblProtists; KNC52955; KNC52955; AMSG_09125.
DR GeneID; 25567651; -.
DR eggNOG; KOG0966; Eukaryota.
DR OMA; EGIMIKH; -.
DR OrthoDB; 8251at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:InterPro.
DR GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd07903; Adenylation_DNA_ligase_IV; 1.
DR CDD; cd07968; OBF_DNA_ligase_IV; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR044125; Adenylation_DNA_ligase_IV.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR InterPro; IPR021536; DNA_ligase_IV_dom.
DR InterPro; IPR036599; DNA_ligase_N_sf.
DR InterPro; IPR029710; LIG4.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR45997; DNA LIGASE 4; 1.
DR PANTHER; PTHR45997:SF1; DNA LIGASE 4; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF04675; DNA_ligase_A_N; 1.
DR Pfam; PF11411; DNA_ligase_IV; 1.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF117018; ATP-dependent DNA ligase DNA-binding domain; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KNC52955.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 403..532
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT DOMAIN 709..804
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 873..976
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
SQ SEQUENCE 982 AA; 108656 MW; AF78D313D869BBE2 CRC64;
MASILPTTTS SVAVGASGGD DGETFASKVL FCNACLVFHK LSQTRKTKAK RQQLQALFER
WGDTRYFDIL RLMLPQMDKE RATYGMKEAN LGKLYVELLG VDASSAAAQS LIHWRIPTGL
GAGADAGDFA EVAERVLRSR CHDKPTLSIK QVNDALDALA RAVERSARLE ILRSLQRQTT
AVEQKWIIRI ILKDMKMHVS ETTVLKYFHP DALEAYNVCS SLKQVALEFA DRNVRPVASS
AAAITLFKPI KPMLAVRCNT VEKALEEMGS APWVIETKYD GERLQVHYSK DRIALFSRSG
KDYTREYLAS VQPLLEKAIP SSVHTLILDG ELVVWNETKQ NYSVFGNLKT IARRDLEKKI
ENDRANGCVD PEQLAALDAM RSSRHSRGPS GNLQADPGDK QSVFYVVFDL LLFNGVSTVN
LPLSQRIEIL ERDVGLVADP KRIEIAPQTI GKSGDDIYDA LEEAMANQEE GIMVKSLNSV
WKAGDRSHGW LKIKPEYGDR TADDLDVLIV GGYYGTGHRS GLIAKFMLGV IVPPAVPGGK
PSVFYSFTKV GTGYSVDTLR NLDAALGDRW IPYSTDSPPP HLILADGFKE KPDVWIPPEK
SLIMVVVTPQ IIKTEKFKAG YTIRFPRCRA FRHDKPWSSG LSLPELQQQF HVNAGTRIGA
RLARGRKLDP PFAAEAQEKE DNLEQRKRSW SHAHRPRCLC WYQCGGVTKV GSLFNGLALC
VIGGDRNAGV TKAELEKALV EHGASISQNP AVDGSMFAVV ARGLVLKVRN IITAHPTSLD
VIHYSWITDC VAAGKRLPLE PRYMIHTTPT TAEHFAKRSD IYGDSYADDA TTDSLRLAFA
QITKQCGRLV EPSEARIAPA ALRSLEDRYG LHTRWSTFRA AVVYLDINAS PIDPASRLAV
TPLDLLDVVI RHHGGTVAPA LDNTVTHVVV SRQAPDRIPA IRNQLRQLRP MYLVDDDWIT
ACVEAGTHLD ETPYKVVGLG SR
//
