ID A0A0L0DLX8_THETB Unreviewed; 1316 AA.
AC A0A0L0DLX8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KNC53041.1};
GN ORFNames=AMSG_09333 {ECO:0000313|EMBL:KNC53041.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC53041.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC53041.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC53041.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL349478; KNC53041.1; -; Genomic_DNA.
DR RefSeq; XP_013754719.1; XM_013899265.1.
DR STRING; 461836.A0A0L0DLX8; -.
DR EnsemblProtists; KNC53041; KNC53041; AMSG_09333.
DR GeneID; 25567820; -.
DR eggNOG; KOG0395; Eukaryota.
DR eggNOG; KOG3417; Eukaryota.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408}.
FT DOMAIN 13..110
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 126..235
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 532..661
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 812..1040
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1112..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1221..1277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1316 AA; 143274 MW; 05CC07D077C44B81 CRC64;
MSSQQSVQTL RKGAVLEGVL FKVGSKHRNW RKRVFVLRPD GMLYYFKSAK SKEPAGVLQC
EGYQVVDYTG RKHGFALEKA HDPSARVWLF AALSTAEQER WMRKLAVAVL GIEFGDPLNM
EDPPLEIIVD AVYSWLGPML AERNVTVSRV ADDFCDGVIL LHVMEIIRYL TADVFHSSPR
TRTQKLDNLR TALNMADDMR VPRDRAEVSA AAIVDGLVSE EQLVRYLFSV MKRQREMSTT
LSTSGSLLAL RDGSSLASTA RLGARAGLYR PAVRTSMVQS ADMDVEALAA AVTNGDADEA
FGKNLDGSGD IGPEYSICIS GPECGKSSLV TRWMTGTYDD SEFRDYDPTL EDFSSHKVMV
DGNVASCAVL DTSGVLTNLP LVRSSYASSS VFVLMYAIPD SDSFHAMTRF FDALLEVHFA
KVHGPKRKFA AKDVVIPPLV IVGHKVDQWR SRGLPQRAAH NFAEAIQRPY LEASAASDIN
TKEVFAWAIR ESNVSKGQLW VDSPMYYDPV PDEALVLPST DDVIFRPPED FAFPSVSFAT
LRGLIEQMAN PHYMNMSFVE SMLMVLDQFA TPLEVATLLV ARLKDKSTKW SDDSGENALM
RTTVRIRVFR VLYTWIRWFP HLWIKNKPMI TLLGTAVKIL KKAKGCKFPW IFLRRVHKEI
KDKSADVASF KATLAEIDGP LPGAPMWIAA GSGANQEADA SLWEQDGSGW RCPVTGVLIQ
GSTAPPHAIR SPRLAALWDA LVPVLDSRLG RGQVVVAKPE AVRSGSLRRR TIVTSTAHSL
EELTSSLRGM PADESEAANS APQVAGGLLA LDVTLVAQQL CLLHQVLFQA VMPTECYNSA
WSKDDGAGAP NVKRLSSQFN TLAGWVATMV VAELDFHRRV ELVTKLIDLA ELLVRYRDYH
GAMAVISGLA MTGVQRLEAT WTAVDDDHLR VLNRLKQTVS GRGQFKAIRN ILARTEEPCV
PYIGMYLTDI TFFCDGNPDR HGFINVFKWE SVANVVKQIL RFQQQVYPFA PNAAVLTWIC
AGRPIDADAI IQLSLLAEKP VEGATIRAVH KNPPLATVEE NSALKSIVTK LSLYTESLLS
KLGRSAPDPA ITELLTAAAI ILDDPYSIPL NDSGLDTLRD SSTTTTTDRG ITDGDISSSD
DDEPSDDVSS ESGHIDDELA KRDAQDEDED GSEAKPEAEP KAGTSFDECS TINAGKDTAD
TLPMPSDATN GTRTKSKRTK SARTASTCTS CTSCTSCTSC TSRGSGSGYS YSSTSGSSSG
SRNAKSSKGS DAAPNDGSAS DQAAPVPAAK DDDAPARSTP ASDVTGYANI SNSSSE
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