ID A0A0L0DS65_THETB Unreviewed; 719 AA.
AC A0A0L0DS65;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=phosphatidylinositol 3-kinase {ECO:0000256|ARBA:ARBA00012073};
DE EC=2.7.1.137 {ECO:0000256|ARBA:ARBA00012073};
GN ORFNames=AMSG_10786 {ECO:0000313|EMBL:KNC55174.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC55174.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC55174.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC55174.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL349496; KNC55174.1; -; Genomic_DNA.
DR RefSeq; XP_013753227.1; XM_013897773.1.
DR AlphaFoldDB; A0A0L0DS65; -.
DR STRING; 461836.A0A0L0DS65; -.
DR EnsemblProtists; KNC55174; KNC55174; AMSG_10786.
DR GeneID; 25568927; -.
DR eggNOG; KOG0906; Eukaryota.
DR OrthoDB; 11111at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR015433; PI_Kinase.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10048:SF7; PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KNC55174.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 91..166
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 197..398
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 422..695
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 80345 MW; ABD21FE872EC0E7F CRC64;
MAQPAPSSPS QSPPPSASSD DDHDDGGLPS LRWSEESGAG PSLVALPSNS NDLNFDDAEM
VSRPMRELLQ QRQSEVWDDD SAVTVCTRPG CGRVFGTLER RHHCRACGRI FCGACTEERI
ELPREFIQFP KPSRAQQASI TSWIWRYLSP PTDKERVCQD CAFRYGDLQN RDVRCIIAVF
EFVRFDLRDL HVLAQVCKTW SRAATICISA LRQLQYRLPS QSFSAREAAM IWWNRAYFVG
HNRWMVQLMR VTDWSRPDHV AELVALACPP TVPSSSPRVF RCSSVLCTRS CRENFQPMDV
IQLLQVVPHP AIRAALVPSI RLAREPVLKA LVPSLVRLIA SDPLASSPVG DLVLDLAAES
LTIASDAFWA LKVAAAEAAD DEPTASRFTR VLHALLVTLG SVHPDWAATL LDAERFEIAC
AAAASVKRYS SARSPLRLPL LSGTRRAYDA LYKVGDDLRR DQAMVNVIAV MDSILRDAGF
VFPVVKYRVV PTGRNRGYIE IVPNAETLED IANKHKTSVT HYLLAHNKNR KGRDYLRDFA
LSTAVYTVMM YLMGVGDRHR GNVMLTHSAE LFHIDYGFIL GEEPFKLLPA SWMRLTPGIR
DAMMDEERKL FSKTCLDAYN VLRRFAPLFM TMLSLGTGTD LSACTEEIVL RFLPGVSDRE
AGALFLSRLH IGPGTITETL QYFFDDTMHN DEPNYFQSLV QNIAAIPTGV FSFFSSSSS
//
