ID A0A0L0DTW0_THETB Unreviewed; 1985 AA.
AC A0A0L0DTW0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN ORFNames=AMSG_10572 {ECO:0000313|EMBL:KNC54913.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC54913.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC54913.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC54913.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL349492; KNC54913.1; -; Genomic_DNA.
DR RefSeq; XP_013753503.1; XM_013898049.1.
DR STRING; 461836.A0A0L0DTW0; -.
DR EnsemblProtists; KNC54913; KNC54913; AMSG_10572.
DR GeneID; 25568767; -.
DR eggNOG; KOG0192; Eukaryota.
DR OrthoDB; 1701853at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR006059; SBP.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR010756; Tls1-like.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF13290; CHB_HEX_C_1; 1.
DR Pfam; PF07052; Hep_59; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF01547; SBP_bac_1; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 492..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 540..864
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1434..1694
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1080..1290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1337..1392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1776..1813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1930..1966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1211..1247
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1252..1290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1342..1364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1369..1389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1952..1966
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 567
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1985 AA; 212520 MW; E35C24F342BD0E57 CRC64;
MGAQAFLDAY HAASNASRGD ARVSLHRFDF SPDRSVYELW LTPDGAPDIV PLYNGADLGG
FIDDGLFLDI SDIWEEADLN SDMLESARRF ASGPDGTRYG VPSMGTTSLC VYHRPTFYAL
GLSPPTTWSA FLDMCDTISI SGRGCLGIDL PYLPPGVILD YLFIRMHGNE FYDAFLAANI
SFTDPRILSS LSAFGELIHR SAFVVDLSSV PLRLWDASGL SSGRIAVYCG FESVASVAVA
NGLAEDDLDA FAFPAIYDGP GATVSPGPAT DGGLGTYMAF GIPTRSLFPD TAKNVLRYMA
KRSVQEALIS THAGTIPAHY SLRNAIAANR TRIAFEVMAA SSNAYGRSAM TGFGYGELVT
EWQDFMFALH VISSQAQADA LVSARIPVLE AIRQAEVLRR ATIPTITPST GSYTGPITVS
LTRLNTGATI YYTIDGSVPS EASLVYTGPI ALLRPGQHVV QAFAIRDDLR RSDTATATYD
IVTPVEVADS NAALLLAIVL PLVVVCCIGL ISIGFVIYRR KAVTYKLQSD SDLVINPREL
LVGQVVGEGS YGTVYAGRWR ATPVAVKRTR TADMNARQLR EFIDESSMLM RLRHPNVVIF
MGVTLEPPAI VTEFMSRGSM YAVLHAPDLF LDPSIVLKWA HAITMGLQYL SHAGVIHGDF
KSLNVLFDSS WVPKLCDFGM SSVKKDARRA AALAGTIKPD ATDDDDITSD TPDSAPRVRF
NNRVSAAEFD DAGSPAALDS WAFALHSSHY TFGLRTKDGL LGQNIGTLFW TAPEVLVQGA
AALSSASDAY SLALTLWELA TRGDLYPGEN PLAVALEVVH GRRPDLDDVP LALAQLKPII
EALWLPNPNE RPTLDEASAV LGTLYSPQAV VYPNTSAAPS GTVGIIRIMA RAALAALVSD
TYNAAARIRA FHNHAPTLAR RGGGSIIDWG LGWISVACYK PAQVVDVVTH FSRIENETHS
LSMAATFGPI VSSTDGLGHV SLSGPVITDL ARLWVFLFGA AGSGFEPLLS VTFPLCASWE
HHLPGGVFFH SDLASELLGM SSVALFQLEL PTTHVAPDTD LVVYQYQRLG DVVVTRNSLP
AEPADRMSPR AMSRRARAAA KTQASAVASK SALVDGSSST PRLDVANPVA ADGHGTNAAP
SPMQSAPSAA SRLTSTASAT STPPPPRVAE LPSSCDTWRP SAPDKNKDVE DGHEQQEEDD
GTAPNASAKS RSKSKSHRKL RRKSRRSRTS RSSRRRKRHR NGRRKSKRSE QAHASSTLSL
SSSSSTSLSL SSSSTTSSTS TSPTATSSRS DALVLQAITS SSSSSPSGVV VDHVALPPPR
EVRRQASAEE YPVMLAAAKP TQDGNSEAQT EPVSSRTPTG TTAVRTKAKA KAPDAERKPA
GRDKKAGASA RAPAEIAPLE EDIIPEMGLS MSLCGESRVL AEWLVPGAVL RRHVETSCHT
WLGSYANVHR ATLDGVPVVI KVLLRQEFRP AELLRVAILA ARAARAASSR LVGPKQACFC
RPNIALVFRY YPGLSLRNAV NIDTGSRMLT AAETRLAMVG LAKSLHELHT RFGAGHGSLR
PSNILLVRPQ GRVIDAHLVD YGLQGIRASM GTMTLVPAIA YMSPEDLAGV PGTRKGDIFV
LGSILYEVIT ARPAFSGTNA LEVGYHIASG HRPPIDAAVI PSPLLRDIIN SCWHADELSR
PTINVIASQL SSTTPSDFKR SNSGGLAAFA SGVVAGSAGG DEAEYGLVGG AGGSEADKEL
RRKLKMRKVA DEAGLTSQFT TESTEVVDSL MHKHVEEEMR KRKEAERGGA STAGAGGQGG
EGNDGEGPAD DDDIYAVPET LRIQEKDNVL TAIVKGAKRR KGFGLVGADT ADKDELASKL
SLTNIVEVDL PAEHLLRNVQ ATADARKDML AKVKAERWAW RKRRGGVEVA DTPGAANRAA
GYRRYRSYTE FGDKPRKGAD RGQVGGRAPR PRPNDPRQEA WDKFRAGGAS DEAFAANYRK
YNMRR
//
