ID   A0A0L0FW43_9EUKA        Unreviewed;       682 AA.
AC   A0A0L0FW43;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Dehydrogenase E1 component domain-containing protein {ECO:0000259|Pfam:PF00676};
GN   ORFNames=SARC_06785 {ECO:0000313|EMBL:KNC80869.1};
OS   Sphaeroforma arctica JP610.
OC   Eukaryota; Ichthyosporea; Ichthyophonida; Sphaeroforma.
OX   NCBI_TaxID=667725 {ECO:0000313|EMBL:KNC80869.1, ECO:0000313|Proteomes:UP000054560};
RN   [1] {ECO:0000313|EMBL:KNC80869.1, ECO:0000313|Proteomes:UP000054560}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP610 {ECO:0000313|EMBL:KNC80869.1,
RC   ECO:0000313|Proteomes:UP000054560};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Cuomo C., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A.,
RA   Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E., Heiman D., Howarth C., Mehta T., Neiman D.,
RA   Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S., White J., Yandava C., Burger G., Gray M.W., Holland P.W.H.,
RA   King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I., Haas B., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Sphaeroforma arctica JP610.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KQ242096; KNC80869.1; -; Genomic_DNA.
DR   RefSeq; XP_014154771.1; XM_014299296.1.
DR   AlphaFoldDB; A0A0L0FW43; -.
DR   EnsemblProtists; KNC80869; KNC80869; SARC_06785.
DR   GeneID; 25907289; -.
DR   eggNOG; KOG0524; Eukaryota.
DR   OrthoDB; 36226at2759; -.
DR   Proteomes; UP000054560; Unassembled WGS sequence.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054560}.
FT   DOMAIN          147..457
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   682 AA;  74865 MW;  881C5CF7BADD87A8 CRC64;
     MIRLQPSLPS RALNGLRLNG SSNLSRRSIR WKASAATESN AADAGVAEGS VARGKYVWKL
     VWSEEELPPP SRDEWYGRSA GSSLATTGVA NYDTEKELIN LPYLREQKAK DIQQIPEFQQ
     SNLFKTHLTN GTCQLPSVDK GQTFESVGFY TIGPGGEELM SAVGQVLRPT DAMALHYRHL
     AASVARQRQH LGKSLDDILI DRARGHVVSS KDPVSHGRHC LIGGSKHDFL VTSTLASQAP
     PAVGRALGGV FANQLKASAV CRYSRFMHTI LWGLVDTPFP KDFISYVSVG DGSVNNAHFL
     SATNLAEYTQ HRGYKAPVVF GISDNGVCIS LKGYEWLQEE FQHKLRMPVY VADGNNMLDM
     WDTMARVTAY TRETRRPATV IFSGLVRRFG HAATDRQSAY LTQEHIQKQA AHNALAGLCA
     QAVGSGVTSY PELLDLYDHV GARARAAFDQ VVNEPKITTR DEISEQTSAP RIAVPGEGAT
     AVHVHLGPHE GKKKGQVMRK HMTKVIDETL EKHRNCVYLG EDVAHGGYYL VTDGLAKKHP
     MRYCVCHPLP TPSDVSLCVC HPLPTPSDRR HILGVDVDES FAEKVLFSSV SAVTAGRVVM
     SVDSTNLLNT RHVLGRDDLW QTPYTDTEEV LGWDEITCYG QGKRLAIVTY GGCVSARPCY
     AVIEDSPYCT ISLPAIPRGF NP
//