ID   A0A0L0FWH1_9EUKA        Unreviewed;       831 AA.
AC   A0A0L0FWH1;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Choline/carnitine acyltransferase domain-containing protein {ECO:0000259|Pfam:PF00755};
GN   ORFNames=SARC_07338 {ECO:0000313|EMBL:KNC80303.1};
OS   Sphaeroforma arctica JP610.
OC   Eukaryota; Ichthyosporea; Ichthyophonida; Sphaeroforma.
OX   NCBI_TaxID=667725 {ECO:0000313|EMBL:KNC80303.1, ECO:0000313|Proteomes:UP000054560};
RN   [1] {ECO:0000313|EMBL:KNC80303.1, ECO:0000313|Proteomes:UP000054560}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP610 {ECO:0000313|EMBL:KNC80303.1,
RC   ECO:0000313|Proteomes:UP000054560};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Cuomo C., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A.,
RA   Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E., Heiman D., Howarth C., Mehta T., Neiman D.,
RA   Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S., White J., Yandava C., Burger G., Gray M.W., Holland P.W.H.,
RA   King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I., Haas B., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Sphaeroforma arctica JP610.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232}.
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DR   EMBL; KQ242170; KNC80303.1; -; Genomic_DNA.
DR   RefSeq; XP_014154205.1; XM_014298730.1.
DR   AlphaFoldDB; A0A0L0FWH1; -.
DR   STRING; 667725.A0A0L0FWH1; -.
DR   EnsemblProtists; KNC80303; KNC80303; SARC_07338.
DR   GeneID; 25907842; -.
DR   eggNOG; KOG3716; Eukaryota.
DR   OrthoDB; 1429709at2759; -.
DR   Proteomes; UP000054560; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF31; CARNITINE O-PALMITOYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054560};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        124..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          199..820
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        500
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   831 AA;  93653 MW;  D95BE2C2EF95FB50 CRC64;
     MAEAHNVSLA FQDTHLHGVE EDFELVHIRQ ENFQVSYNHH GVVLFIPNPR SIGRRIAKKV
     YQFRNHVVSS LYPLPIQLVY VVSIAYIGFM LDADREGWWR NNAIADFVWA VDSKMNLLSS
     HLPIAVRVAY QSAIVGVLVI MIFMYIHRLL LKVLLSYQGW MDAPKSKMTL AWGAMLKIFY
     LGGGRQPNTY SFNVAMPTMP IPSAKDTVAR YLKSVEVCLS PSKYQYIKEL ADEFLASSEL
     TKMQGLLHVK KLMTSNYVSD WWLKYVYLRG RSSLLINSNY YGLGFASHLP SKKQTSRAGF
     LTHELIVLKT MLDREQLEPL LIQKLVPLCM NQYQFMFSAT RVPHREADEI RQYDSGESRH
     VVVNYKGLMY KMEVFDKQTG EVSTPHHLER SLEYIVQHAD HRLASENFSE ADLSIPALTG
     ANRTVWAEAR DKHFSAGVNR ASLNLVENSI FTLCLDDHEP QTWTEQGKNL LHGDGTGLWA
     DKSFNLVVFR NGIAGINGEH SWGDAPVAAH MWETVSGREI KSDPYDRKTG CLKPSTAEED
     KDLVSTDSLA TLLTKNLDAE AKKGSVVSGK ARVPTAVNFR MNPDLEKTIL ECKAEIIAAG
     EDLELNVFSF DKFGKDRIKK VKCSPDGFIQ MAFQLAYYRE AKIHPLTYES SMTRMFKDGR
     TETIRSCTSK AAAFVKACED PKVSKAETLE LLRDACRNHS EISKEAMKGE GVDRHLFALY
     VVAMGLGAES KFLSEALNMK WKLSTSQLPQ RQGDPADWGG KHVQQDDKYF SPSGGFGPVD
     DSGYGVSYNI AGEKTIFFHV ASKKSCPETD SVKFSENIQK ALQDMADLLE D
//