ID A0A0L0G7D7_9EUKA Unreviewed; 526 AA.
AC A0A0L0G7D7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=SARC_02975 {ECO:0000313|EMBL:KNC84834.1};
OS Sphaeroforma arctica JP610.
OC Eukaryota; Ichthyosporea; Ichthyophonida; Sphaeroforma.
OX NCBI_TaxID=667725 {ECO:0000313|EMBL:KNC84834.1, ECO:0000313|Proteomes:UP000054560};
RN [1] {ECO:0000313|EMBL:KNC84834.1, ECO:0000313|Proteomes:UP000054560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP610 {ECO:0000313|EMBL:KNC84834.1,
RC ECO:0000313|Proteomes:UP000054560};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A.,
RA Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Howarth C., Mehta T., Neiman D.,
RA Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., White J., Yandava C., Burger G., Gray M.W., Holland P.W.H.,
RA King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Sphaeroforma arctica JP610.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ241738; KNC84834.1; -; Genomic_DNA.
DR RefSeq; XP_014158736.1; XM_014303261.1.
DR AlphaFoldDB; A0A0L0G7D7; -.
DR STRING; 667725.A0A0L0G7D7; -.
DR EnsemblProtists; KNC84834; KNC84834; SARC_02975.
DR GeneID; 25903479; -.
DR eggNOG; KOG2128; Eukaryota.
DR eggNOG; KOG4424; Eukaryota.
DR OrthoDB; 12619at2759; -.
DR Proteomes; UP000054560; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054560}.
FT DOMAIN 1..112
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 172..346
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KNC84834.1"
SQ SEQUENCE 526 AA; 60147 MW; 3A0C06BE70028B48 CRC64;
QYRWLEVCLP GSPLPPADEL EGFLRPGVTL AHLGQSFDRT ETTAKAKIFD PDMDLFLQEG
LKFQHTDNIN LWFDAMINVG FPKVFMPDTN DIYEAKNLPK LIYCLHALSF YLEKTGLTPS
IIPLTANSIS FTDQQKDQMH KVLADISMPE FAKANTAVEE ELLASTMKKM EKRKQIENEI
LTTEKTYFDG LKRLHENFEK PMREADAKRN TMIPTAASDK IFSNTKMIRS TSEAILPKME
QGQTTEAILF LYPFIRDLYT DYAVAYRESA AEIEKQKAVR EGFDAFLKRQ PETLESLLLT
PVQRVPRYLL LLVNLLSSYD EQDPDYASLK KAVKVISSVA DEMNEKIREY ENFQAIEDVR
VRLWGTGTPA LHTPGRVLIR VGDLNKQLHK DPTQKHPRRL FLFNDILIYA VAFDDKNYTA
SATKGVMDAA SVVAEKTHKY VPKGLRDFGR KIKESAGEVL YNPNPNLTTY VFKSSVRLDK
LELSDTDHQF FKLSHEGKDY RFESVDNHAA WIADLDVAIR AAKKKH
//
