ID A0A0L0G9M9_9EUKA Unreviewed; 1053 AA.
AC A0A0L0G9M9;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=SARC_02078 {ECO:0000313|EMBL:KNC85737.1};
OS Sphaeroforma arctica JP610.
OC Eukaryota; Ichthyosporea; Ichthyophonida; Sphaeroforma.
OX NCBI_TaxID=667725 {ECO:0000313|EMBL:KNC85737.1, ECO:0000313|Proteomes:UP000054560};
RN [1] {ECO:0000313|EMBL:KNC85737.1, ECO:0000313|Proteomes:UP000054560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP610 {ECO:0000313|EMBL:KNC85737.1,
RC ECO:0000313|Proteomes:UP000054560};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A.,
RA Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Howarth C., Mehta T., Neiman D.,
RA Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., White J., Yandava C., Burger G., Gray M.W., Holland P.W.H.,
RA King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Sphaeroforma arctica JP610.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; KQ241686; KNC85737.1; -; Genomic_DNA.
DR RefSeq; XP_014159639.1; XM_014304164.1.
DR AlphaFoldDB; A0A0L0G9M9; -.
DR STRING; 667725.A0A0L0G9M9; -.
DR EnsemblProtists; KNC85737; KNC85737; SARC_02078.
DR GeneID; 25902582; -.
DR eggNOG; KOG1967; Eukaryota.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000054560; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000054560};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 49..310
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 656..1009
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
FT REGION 436..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 115909 MW; 79F4B69D0E156ACE CRC64;
MTENALDQAG VSNLCQEYAT GTPERRAEVV STLVQGIYNK SIRLEHVVMG LAPQLTSTEG
RQRNTGMTML SELLSVARTH RFAWNEVNTL VDFYLARMED YECTVPCLRG LSAVARNQKL
TKDQVTAVIN TLFAQVRVNN LAQGERLEYL LMMEHFLETH IDACKDLGHE FVFGYVQAID
GEKDPRNLVK VFELTTKISK TLDISRFVGD LFEVTICYFP VTFNPPADDP HSITKKDIID
GLNNALAASP LFAEFGIPAL FEKLESHVDD NRVAAFRTIS ICAPNYSRSP TGGLMPHMQR
FWDVVKREMY EYGEKKVEGI CLTSTRRLFA AVSQTEDSAS VKAFTEKVVQ ECLSEFKDQS
DILTLTPSSK IIAAITGASG LTCEVVSRVF VPTVVEQYSR PESYPQFKHA LLEGLLNFVR
AHNMLYFPSS TMKHGTHTAS EVKAQPPQTP ADGATAGEVA MQDAEDTDEG PVHTVLRDHL
QTISGLFYES CCAEQPALRA LACYGIEGLI TSRQLTAKEV DQATKELSSM AMIEDDTNVQ
TAMVDVCATV ARLVPEAMLV NAAKPILAQF EECEEEKVAY VLLVMDALAT AEHLGTSMTR
HATEKLLLCK AIDAPFVKWA EALDRIVASM CAQDTDGDSP LVQPRHCADA VVSDVLTLLL
PHVFNLTGHT PRDSNYWNPA LLHSLKNTVV TAARKSTTDL QQSLIMQMSV WEACFTDHNR
DYTPYRLALY ASAFVNLSGV AQPALTTQVL QEMVSLALDA TATEASVLWA NKILASACNK
AQDRSALEAF VQRVADIITT VILNPPTESP ENTPSQTPLA VRTWAWLVKG LLLRAHKSGS
QMLTTLISWI GDVHAGQCAA QAFEVLVTPY DDCLCKASHA KTSALYQQRL FLMALDPLVA
GYGSGKEGRD SDVVKARYLT ALSYLLQYAP KQVLTEQLPP LLPMLLASLS MDSPDLLKST
LKTLVGLMND AATVLQVHVD SLIPLILKLA HASTKMDVRM AALDCVNAMS SLPYHVLHPH
KPAVLAGVRV CLGDKKRLVR RSAQVCNNTW YLI
//
