ID A0A0L0GF83_9EUKA Unreviewed; 3517 AA.
AC A0A0L0GF83;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=SARC_00211 {ECO:0000313|EMBL:KNC87705.1};
OS Sphaeroforma arctica JP610.
OC Eukaryota; Ichthyosporea; Ichthyophonida; Sphaeroforma.
OX NCBI_TaxID=667725 {ECO:0000313|EMBL:KNC87705.1, ECO:0000313|Proteomes:UP000054560};
RN [1] {ECO:0000313|EMBL:KNC87705.1, ECO:0000313|Proteomes:UP000054560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP610 {ECO:0000313|EMBL:KNC87705.1,
RC ECO:0000313|Proteomes:UP000054560};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A.,
RA Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Howarth C., Mehta T., Neiman D.,
RA Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., White J., Yandava C., Burger G., Gray M.W., Holland P.W.H.,
RA King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Sphaeroforma arctica JP610.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KQ241601; KNC87705.1; -; Genomic_DNA.
DR RefSeq; XP_014161607.1; XM_014306132.1.
DR STRING; 667725.A0A0L0GF83; -.
DR EnsemblProtists; KNC87705; KNC87705; SARC_00211.
DR GeneID; 25900715; -.
DR eggNOG; KOG0892; Eukaryota.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000054560; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054560};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2269..3050
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3147..3465
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3485..3517
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1903..1934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3439..3467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3517 AA; 392131 MW; 358AB0F1FDE372A0 CRC64;
MDWDLDYRST FERLHADLVK TRADARSQLT LLLDSAGDLD RFDSNTVRDN DRHVMWQEVA
NAVVTCVDKE ATIAKKKKAT ADPYKNLREA CELLRLVLKL SARHGYPLIP MESMEKLVSE
HITPIITGEA AYGAIPVLSI YRGMLSEYIL PVIDYIGTIS DSDWTKMFSF FATTLRDNTS
PRDRENLCKV VHALIYYEGI RLASVARYVT SCLTAFFKAN CGEGLSTKLM LNAATHFCQA
VALDLPGVVR KLDSYVSPNL VSLWDTRRVE LKHEIVQYIR FRMRFYRPAR PSQSPSPATS
HRPAGSRVVP LDRHITNVVL KEIPSEDGVY KCVLRDLGEH VERTSRVHNA VPFIGRRTTT
STYSTISAYE HQCYMDMAAD VLFFRAPECF FPGMSTTMYV DDMPPGKAQS QSGGTISHPA
EGIELDLDLG ITDFDTTLPS NSRSFAPSNA LLGPVELAQE LVSGDLLAIG ITRALAVKFP
SLSAECKIGW IRTMVEVLAK SHQTKNETER VSAAAYALEG LAMACDYRGE MVEVQTELWG
KVVSELVAAY RRVASAGVGL FGEKQQVCTN NVLYSLQSIV QQRLPAAGAI AELLDQLVDM
LHTAGAKPTR VSVDLVMLVI RLEGNTSAQH TGSSGDMGTN VLLSDVLALG GSSVKPKLTA
WLLSALQNSP KDAQRSRRPG GEYTREAPDL TMGDAQAIGA ALFALSYQNG AQFFCPEKLA
DGVMEGGEAD GCYSYLGVTP RVERTQQHTR KYMKLCTLLP SLDRDNVRWE EKMLSLVNGM
FALDEGVGVI LSESPTTQME QREQESCRLS PTVIPALETQ VLETLYAAEK KGEETPMPAS
SSSTNERDIA IRDDSTGLPY KFGHIAILLT YTAMSVHLGG MILAPGHPLT TLLSTRMAEI
VATLRLAESN PIVLEGTAKL MEMLFNIPCA HDNLEDHMHA TWDGEDTCIG MIETLQTIVE
LSCTQLLSDV SNICLAAVRL PWDFTVVVAQ DNSVEPRSKK KRRLNNGMLQ AHDSFGDDSD
SDTEFASSAN SRMKYKAAGL VPSRVHAASR GGLALPAAGD VIREIHGKTA MIPILRTLKA
VLGGVKAGGS ICKSAVATDI DMALGETLTR EVRDKTTLLL MPFWHALSMA LPATYADHVM
MGTQGFLQHW NTPPMQLYAL TIISEILPEV MAAGVTRQQC ASEDSAYSIL VFLLDTGFNH
LFNEQMLVGP ERLLYLRCCG YFLAFLPISG VDISSETPGA EVIITIGEVI EAALFDSSFQ
LRVLAGEVLS PFLRLRSDES QVVYITAFRR DIEERLQSTV GTDRISASVL ETSMHNLMLV
GTRCQCVAKI CFSFMLWVGH HKAPYTLVVD EILGFSLLLD YSTPEEIYAE FVPFALYDWV
YKFDIILEDF PAPALGFSSF RSLSTEFISD IVALFFYKGT TNLLDRVAKL FCKQCADLLL
ENFPKVHAFA LPQLCSEGYS DESFAELYKD IGAHRCLEII TDDPESLIVE LLLTLYEPSP
ASDSTTATTT VDVPQPRREP HDILRAISSA FAYKWLGRSS DPVPQPPTCD STSMLVSLSQ
INRLKIGAGD IKAESVRSSP GVAAVVLMKL GKKLAECNYP PTRRRLLSAL SLYLNWIGSL
LGNNLVYRSA VSIQLSCLQI DEFIFREECI DMLANTCAFG LEHSPDEAGR LLSLVLSALL
RISHPYGAVN CKLPGSADSD VDNISMCANA DTTSSGSTRV AVASRTTEKA TNLIKQLLVD
KSIETNTLYY THLQRTEPLP ECTHFVAANK TLRRAYGKLS LKQEIRRFID NGRTLDAGSR
LAGIKHLTQQ LRERRDKLNI LAATEDDDNV TVLLADLVSS LITMCRPEVP PDVQLAAGSC
LGEVGCIDLR VQAFRESRLL GEHSEGSKLA RAISDLQQNT LSSRNASRAV KQRSASRKST
QDIDEVSGEQ TSSGLVAEQS KESIAKLKEV RSLTLLAKLT EFIADPNSLV VEAAQKSLFC
LLELPEIQTA VREIESLENT EDESHIAKYL APFQTRLFTN RRMQKYARLY KYLDEIRGST
VETLTPNSRH VGVRKLLSSL MFLPHDISMW TRVFQDSNPQ QDQKSRKARV DYVVWIQSIC
CSLILNFGVV DKSLLSCYFV CPYKYDFCEF LLPELIYSLL KESPSPSGSR VLNSPDMYRQ
LSDGFRAFFK LAASKVEHTA DEKKAVRAIL SALDHLRRVS LPIGGRTVYG SGCDVSYWEL
SMSSAAASLT GRKGSGKTSR SKRNLSRASL GSVMNVDKHE VALDIDYKKV AFAAYNAGSY
LSALLYLELW CGITNNPTHS ATFDAMAVVD KDLPDHKRLF LHIYSAINEP DSLTGANFCL
SYTTRMLAQD HQRDYLGTFS TSDLVLSDQR ARLRDMHGGL GTDRMERKRV GHNPILAAMQ
NMGYAHVLEY YAAGLVAKHP ELESEIAEYQ YEAAWRLGQW DASFSLSPTP RSHPLTRLTD
ASSMDVDDLV TGQQKSREVL QQLTFVCLKG LADNNASVFS SAARQLHLMV VQKLGQANHE
NMAGTYSALA WLSSLNEMNE AHALLRATSS IGSLSSLSSP SKASIQRTVV TRTAANVDSM
VKMWNKRLNC WRMNDFAFTE PVLAVRQVLL GILRVRSEFG TSVLSPSTTA RRLQLVHLSE
YSNLASNADR LHLARQLILE MRRLSVDVQL PVRSLQDSSN ANRHNISTTT VGNTASEFSL
WMLQSAEASR KEEQWETALS WLHTMRARLS KDRTDVSHHH QPLDSENGDL VALDQLTAKV
ALLECKWKSI FQADGPEAQI TEMQRCIAEY EPVCEPESLA EAYHTLATYA DGHYQSIIDM
LASPEWKETQ QVKVSMKQNL TLMKERLNVV TAEYKDLGRK LKIDLSKKVY TDHRREQTDW
SHKFTKPVDI EYKNRLDVVH DERVLLTREM NLRSRELNYD AGTAKKVETN LNNFLGVTLQ
NYMRCLEISG KYDIAVFRLM SIWFSIDQNK LSLSKLYTLA NSLMRKDLRK IPSFKFIPLI
YQLAARLDWS DDLNNPKSVA FASILYQLVY RLCAEHPFHG LTVIYALKNS DVNSSMDKVN
AAKKMLHELG KESKISHIVQ DTLSLSNAYH ALAKVHVPKT ATTMGFDTLS ENDPIMQVKQ
LRIPITTCPP PVDPMAVYKD IIRIHSFSKR YNLVGGLHKP KQIDCLGSDG VKYKQLVKDL
DDLRQDAVMQ QVFRMVNKLM VKNSDTKKRN LIVRTYNVVP LSPQTGVLEW AMQTTPLSEY
LVGSGRNANN GAHQRVRPQD WHTRSVREKM SKVSDSDDRI KLNTFEECCK NFHPVFRCFF
LEKFPDPMDW FDKRLQYTRS IAASSIIGYI LGLGDRHPSN ILIDLKTAQL IHIDLGIGFE
QGKQLPMPEL VPFRLTRDLI DGMGIQGVEG VFRRCCEHVM GVIRENQALL LTILDVFIHD
PLHTWSLDTT KAMNMQRSNT QESAVVAPSA KSIKSKQGEE PRNTTKGHRI LLRLKDKMSG
REQGISYTIR GQVDHLIKEA QDPKLLSIMF AGWQAWV
//
