ID A0A0L0JLI1_9ACTN Unreviewed; 6471 AA.
AC A0A0L0JLI1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:KND26274.1};
GN ORFNames=IQ63_37575 {ECO:0000313|EMBL:KND26274.1};
OS Streptomyces acidiscabies.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=42234 {ECO:0000313|EMBL:KND26274.1, ECO:0000313|Proteomes:UP000037151};
RN [1] {ECO:0000313|Proteomes:UP000037151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCPPB 4445 {ECO:0000313|Proteomes:UP000037151};
RA Harrison J., Sapp M., Thwaites R., Studholme D.J.;
RT "Genome sequencing of plant-pathogenic Streptomyces species.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KND26274.1}.
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DR EMBL; JPPY01000213; KND26274.1; -; Genomic_DNA.
DR PATRIC; fig|42234.21.peg.7735; -.
DR Proteomes; UP000037151; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd08953; KR_2_SDR_x; 3.
DR CDD; cd00833; PKS; 5.
DR Gene3D; 1.10.1240.100; -; 5.
DR Gene3D; 3.40.47.10; -; 5.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 5.
DR Pfam; PF00109; ketoacyl-synt; 5.
DR Pfam; PF02801; Ketoacyl-synt_C; 5.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 5.
DR Pfam; PF14765; PS-DH; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 5.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 5.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000037151};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..433
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1446..1882
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2350..2424
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2470..2888
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3490..3566
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3586..4014
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4242..4320
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4348..4763
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 6097..6170
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2312..2341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2432..2455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2974..2995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4907..4943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6018..6089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6050..6073
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6471 AA; 685626 MW; F19F2E58427CFE59 CRC64;
MDDTDAIAVI GLSLRLPGAD TLSEFSRHLT EGRSLISEVG PERWAKERWF GSPKRGAEKT
SSVWGGFVEH ADRFDAAFFG ISPREAESMD PQQRFALELA WHAVEDAGLR AGELAGSRTG
VFMGVCHADY AELMERDGAK TDAYFPTGTA YSIISNRISY WFDLQGPSIT NDTACSSSLV
SVYEAVTALR NGDCALALAG GVNLCWSPKH FVAFSQAGML SPTGRCRAFD QGADGYVRGE
GGAVLLLKPL ARAVADGDLV HAVIRGAATN HGGRTSSLTV TNPAAQSDLV EGLYTRAGIR
PETVSYIEAH GPGTPVGDPI EIVALKRAFR SLHDAQGTRP APDSVGIGSV KTNIGHLEGA
AGVAGIAKVI AALAGKVLPA TVGFEKQSRL IDLDDSPFRI VRETQPWDAP APRRAGVSSF
GFGGTNAHVV LEEHVPAGPA DEDPGRAIGP YVVPLCARDP ERLREVARRL RTFLETDRPT
ALRDIAHTLR TGREPMAARV AFVAADVPRL LGLLDAFTDG TLAEGAAHGY PDAGATRWAE
GGDPLPGYAG ARRVRLPLYP FARDRHWFRT RPDEDRGAPH PLVPRNTSTL GEHRHTCVFT
GTEPFLDAHR VHGTRVLPAA AQLELARASV AHAVSDAGAS VRLTDTVWLR PLTVDTDPVE
THIVITGRPD GTLAYELRTT NGDEPVVHSR GTASVGTAGA GEEPERLDLT ALRASCPTSR
DPGEAYAALH AAGLEYGPAM RALTAVRLGE GQVLARVQRP AADVADPAVA LPPSVLDAAL
QASVLLQAAL SPEAGHALSM PFALDRLDVH GPCADTMWAW VRHRGGGKGL ATFDIDLCDE
EGTVRVRLRG LAQRTVAPAG AADEARVPAA EAPGFDGSLL VAAGSRWVPA DVSGTTDGVT
VHGFLAGRTD AYAAEVSAAA GVPFSVLPAV TPDSVADGVA AVLDLVVGRV QEVLRARPKG
AHRFLVLVDD RVPRRFHAPL TGLLRTLNLE NPSVSGRVVR VAGFANAPAE RVTELVRAEA
GDPAVHDAEV RYGADGVRQV WRPDPVEIGL DARVPALKDG GVYWVTGGLG GIGRSVARYF
ARRPGVTVVL SGRTEGEGTR AAVEELRAAG VDAHHLPADV GSAADVERAV RSILRTHGSL
DGIVHAAGTL RDGYLLTKEP GDVAEVLRPK VSGVLHIDAA TRGVPLDFLV LFSSVAGVYG
NPGQGDYAAA NAFLDAFAHD RQALVDAGER SGRTVAVSWP LWADGGMTVD DVTLASMRRR
RGWEPLPTEA GLRVLGAALR DTPEHVVVAY GAEASLAAAE PRAEVAPRPA VPAATFTEAD
LTARTADLLK EVLSEVLHHD PAHLKPDVGL IEYGIDSIGV LEATERLGEI FGPLPKTLFF
EYVDIAGVTG YLIEEHRPTL EARFGQDTGV EAAEAAAEYV APDPAPDPGP ALVVREPVPT
PVPDDYHDIA IVGVSGRYPG ADTLDELWTV LEEGRHLFQE VPRERWDHGA IHSPERDVPG
MSAIRTGTFL REIDTFDPRY FRISKRDAER MSPEVRLFLQ VGVEALEDAG YSRETLRRRY
DGDVGVLVGT MSNHYNLYGF QNSLTRGAPA TGSYTATIPN TLSYFYGFTG PSIFLDTMCS
GSSTCVHQAV QMLRARECKM VVAGGVNLLL HPYNLITSSH EHFTTATSDV IRSFGLGADG
TILGEGVGAV VLKPLVEAER DGDQVYAVIK GTALSNAGVR NGFTVPNPRM QARAIEKAID
DSGVDPRTIT YVEGHGSGTS LGDPIEVRAL TSAFGKYTPD KQFCALGSVK SNMGHLLHAA
GMIGFAKVLL QLRKRTLVPS LHSEELNPDI AFEDTPFRVQ RELAEWKPAV TSENGVTTVH
PRRAGITSIG AGGMNSHIVV EEYVAPPASS GSVPRGAELF VFSAMTDAAL ETSLARFRDY
LAAADESDLP SIAHTLRVGK NELPRRWAFV AKGRTEAVAS VDRYLAGGRD QDAALTGADP
AVRGLALDWA GGAGIDWAPL TGERPPRRIS LPAYPFERVR CWTEPEPGAP SVLAPLAVRE
KVHPFLGANR SDVDGLRYVL DVHLDDLADY GYARDKVRGI VPTFAVDLAL AVGRATGFAA
SPRVSGLRLY GPVVWGETAR LVTTFTPDGR EAGVGIVVRE DRDGARSVVA EFVVRPGDGR
PAPAGGVHRD AVRVLDRDGV LAELAEGGVV PEAVRFGVSG ASWLADGRLV LAVGVPQVRQ
DHVLRNVRIA PHVLAAVAHG VRLAAKRDGA ADWARQVPHG FEEVRVFDDT RGADEVAHVV
LDPSAGRVLL TGADGAVLAE LTGMRWGEAQ AGPSYAEAER RETPVPAAPV RTEPAPVEAA
PARDEDSLVA FAVDRLRLLA ADILKFDAEE LDAHTGFDAF GFDSMSLVAF SKLIKEELGA
EPTPAVFFDV NTLAALGRHV VEEYGEAVRA ARGEAGGEAR GEATPVQEPP VEATPVQARP
VETPADPGRP MPVAVIGVAG RFPGSPDLDA YWANLAENRD CVTGFPVHRY DAAYAKTVEE
AEFPKHAGIV DDVDAFDAEF FQIYPREAEL MDPQHRLALQ TVWNAVEDSG YAPGALPRDT
GLYFGVSGTD YATLLTTYGV EPDAFTSTGN AHSILVNRIS YVLDIRGPSE PVDTACSSSL
VAVHRAMEAI RSGACEMAIA GGVNLLLSVD TFVSAHRAGM LSPTGRCRTF ARDADGYVRG
EGVGALVLKP LDAAERDGDA VLGVLVGSAE NHGGRANSLT APNADAQADL VATAMRGIDP
HTVGYIETHG TGTVLGDPVE VRALRTAYRG LGAEDDAGIA LGSVKTNIGH LEAAAGVAGL
LKVLLALEHD TIPAALHSGD LNPYLELDKG PFRVVRENEP WPRGRSPRRA GVSSFGFGGA
NCHVVVEEYV PGPAPDDGSA PVATPVAVPL SARTPERLRQ VARDLLAHLE RTDVPLPSLA
WTLQTGREAL RERVGWVVGS RRELADQLRE FAQDGPHTGL RGTVTRPAGG TPVTDGDPAR
LLARWIAGDA VDWRALYGSS TPRRAHLPVY PFAGERYWIP GSGPALGAPE AGHPGTGTAL
LVPRWEPKAT AGSGEVPPRR VVLLCGELAA GAREFIEPGV RCVTVASSRR RLDSRFGDVS
RQVFRAVRDV VAEAVPGRTL VQVVAPVSGA DSVHLALSGL LRTAAAEDPS LTAQLICLDG
QFDGAAVAAR VAENAAAEDD VVLHRGGVRS VLAWRTATAP QGGRDLPWRD GGVYLITGGG
GGVGAVVART IARDVERPTL VLTGRSPRDA RIDALLDELR DAGAVARYAR ADVSRWEEVR
HLVHETGQPH GIVHCAGVVR DAALVNKTDD DWEDVLAPKA DAVVHLDRAV GRAPLDFLLL
CSSGSAVTGN PGQADYATAN AFLDAFAGLR NARVAAGERS GRTLSLGWPL WRDGGMRVDD
AVRARLWTSR GLAPMESATG VEALVAAWGL KEEGQVWIHH GDLSRVPDVG SSRAPAAPAT
PAVSAPVPDR AVDDTLRRLV EIFAQVTKVA STAVDGDAPL PDLGLDSIMI VQLNRELALA
YGEVSKTVFY EFPTLRALAE HLAPKGRSPV PETAVRTPVP AVHTAREPIA VIGMTGRYPG
APDLTRFWAN LTAGRGAVRE VPADRWPLDG FYEPDRATAV ANGRSYSKWG GFLDDFAGFD
PLFFRIAPRD AYAMDPQERL FLQAAWEVLE DAGYTPEELG ARHGHRVGVF AGVTKSGHAR
YGTRRLPSGE TVVPALSFAS LSARTSHVLD LRGPSMTIDT MCSASLTAIH EACEHLYRGS
CEAAIAGGVN LYLHPLDYVE LCRSTMLSAG DELRSFGKGG DGFVPGEGVG AVLLKPLSRA
EADGDQVLAV IRGTSVNHGG RTHGYTVPNP VAQAELIRDA LGRAQVSARD IGYVEAHGTG
TELGDPIEVT GLTLAFRQDT DERGFCALGS VKSSIGHLEA AAGVAGLTKA VLQLRHRQLV
PSLHAEELNP NLDLDRTPFF VQRELADWPG DRPRLASVSS FGAGGSNAHV ILEEHVSQSA
SGRAPDQTGA EQLVVLSART PAQLRAHAER LADHLAGPGA GAALADLAFT LQTGRVAWDE
RLAVVTASVP ALLAALRAHL AGDPAAPGVF RGTAGRPNGT VADLTEDDDL RDLLVTRWTE
TRKLTKLAAL WTEGVPLDWP ALHAPTTPRR ISLPTYPFTQ DRYWAGDLEA VADGAGAGYT
APETGADSAA YGAGAAYGAP EPGPVTATSN AGAAPGSAES APPLGDRVRA TVHAKLAVAL
AMDEGEIDGR RAFAEYGLDS ILGVRFVHEL NETLGLDLTT SVIYDHSSAD RLITHLLDDH
RAAITLAAKP EPAPAAPAHL APAASAPRPP IAIVGMSGRF AGSDSLDELW QHLAEGHDLT
GEAVRWPLPA MDDAGNPRCD RGGFLERIDQ FDPLFFNISG VEAAVMDPQQ RLLLEESWKA
LEDAGYAGTA VNERDCGVYV GCWEGDYRNL VGEDAPAQAF WGNLGSIVPG RIAYFLDLKG
PAIAVDTSCS SSLVALDLAC KDLWSGETDM ALAGGVYVQS TPRLFELAGR ANMLSPTGSC
RAFDHRADGF VPGEGVGVLV LKRLDDALAD GDHVHGVIRA SGTNHDGATN GITAPSSVSQ
ERLLSEVYEK SGVDVGTIQL VEAHGTGTKL GDPIEFQALT RAFRKGTDKS GYCALGSVKT
NLGHTQYAAG VAGIFRVLLA MRHGQIPASL HFERGNEAVR LDGSPFYVNT RTEPWPAPAH
GPRRGVVSSF GASGTNAHVV LEEPPARPAP RDAAPAHLVV LSARSREQLA EQVARLAAHC
RTRTELDAGD VAWTLAVGRA HFTHRFACVV RDREDLIGVL EQGLGGPRAL TGEAKSATPA
TVPTDLHALA ELYVRGAELD FPRVFTGGLR RVPLPTYPFA RESHWATATP PAATPPTTAA
PAAPARSAPA PAHPTLTDLL PDPTTPGTLR ATLHLTGDEP LLHDHLVRGG RVLPGVVHLE
LAREAAVRTL RTHPASGLRM RDVTWVRPLS VNAPLHAQVT VRPDADGVTV TIGAPGEPPY
SQARVQPSTA PAPAPLDLPA LRAACPTRVP GTRITEALVA AGISHGPSLR AIDEAYVGDG
TVVARLAAPA GHPYVLHPAL TDSAIQASAA LTLDGDAGEV RVPFALDTLE LFGPCEDVMW
SVVRAVAPGR LDIDLTDESG AVRVRLTGYT SRSVPDSAPA LFSPAWEPVS AEEWAPVSGQ
VLVVGTSGEA AGDILRLFPQ ARFWQLAPSA SVEETAAELA ATGGIDHLLW LAPDTAPHVT
DAAGFTAAQE DGVIAAFRMV KALLSTGADA RPLDVTLVTR SALATYAGEA TRPAHAALHG
LFGSLENEYG HWNVRRVDLD ETGGLSGLPT RTPGGTWARR AGQWLRRRLV PTASAHLETV
PYREGGVYVV IGGAGGLGEE WTRHVTERHG ARVTWLGRRP QDAGIETRLH AARGRGEVRY
LAADATDPAA LRAAYEDVKG RYGRIDGVVH SALVLRDRGL AGMAEDDFRA ALAAKVDTSV
AMAQVFAAEP LDFVLFFSSL QSFVTAAGQS NYASGCAFAD AYANLLGREL ACPVRVMNWG
WWGSVGSVAS AFHEQSMARW GLKSIEPPEG MAALGTLLSG PQPQVSYVKL TDPGAIEPID
PTLRTTVYAR AATGVPPETV AAHTGQADEE LLRGVAAWRR DERDPLLGQL IRAHLEALGV
VRAGEPAVDD ATGLARGGIH ARYSAWLAHS LRIMPAWAPP LGVLEEQWAR ECARWSVDPD
KAAELALVDA TLKSLPAILT GRVPATDVMF PRGSVELVEG CYRNNRVADT FNRTMSAAAS
GIVAGLLRQD PGARIRVLEI GAGTGGTSVG MFAALRPYAS SIETYTYTDL SKAFLNRAQA
NYTPDAPYLD CRRFDVEQPL AGQGIEAGSY DLVVAANVLH ATRDMRNTLR NAKAALRDRG
WLLLNELTAF DVFSHLTFGL LEGWWLSEDV PLRVPGSPAL SPEAWREVLR GEGFTSVVSL
LPSARDLGQQ IIAAEGDGIG RQKTAGPTGK AAAGTAGRAN TATGGTQRPT PAPATPPPAA
RPVTAPAPTI PFPTAQTPAA AATPAPAAPA PAASSAAVLS AYLTDKAAET LRVPAEKIDA
GTSFIEYGMD SILVLQFTNE LRQDLGELSS TVLFEEDSVG RLAAYLMANR AEEVRTLVAG
LHPEPVRDEG AVDVAEPLLG TLFHAAVRSA PPAQGAALLK SAARLRPAFT TGADTPDPET
LYLAEGTDEV GLVCLPSLIA PTGAHQYLRL AMALRGRRSV WATGMPGYGT GDPLPQTLDA
AIDRQVTALR GRFAGRRFAL VAYSSGGWPA HEIARRLEAD GTPAAALVLL DSPARPGDAL
ADGMITITRW LADRYPQLPA DDEQLTAMAR YAEFFEGWEP RPVPTPTLFV APSAPQALAE
VVGEASGRRW LPDWPLDHTR LEVPGNHFTL LEEHAGTTAN AVHEWLTRRL G
//
