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Database: UniProt
Entry: A0A0L0NJG5_9HYPO
LinkDB: A0A0L0NJG5_9HYPO
Original site: A0A0L0NJG5_9HYPO 
ID   A0A0L0NJG5_9HYPO        Unreviewed;       865 AA.
AC   A0A0L0NJG5;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   11-MAY-2016, entry version 4.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=TOPH_01035 {ECO:0000313|EMBL:KND94272.1};
OS   Tolypocladium ophioglossoides CBS 100239.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae;
OC   Tolypocladium.
OX   NCBI_TaxID=1163406 {ECO:0000313|EMBL:KND94272.1, ECO:0000313|Proteomes:UP000036947};
RN   [1] {ECO:0000313|EMBL:KND94272.1, ECO:0000313|Proteomes:UP000036947}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 100239 {ECO:0000313|EMBL:KND94272.1,
RC   ECO:0000313|Proteomes:UP000036947};
RX   PubMed=26215153; DOI=10.1186/s12864-015-1777-9;
RA   Quandt C.A., Bushley K.E., Spatafora J.W.;
RT   "The genome of the truffle-parasite Tolypocladium ophioglossoides and
RT   the evolution of antifungal peptaibiotics.";
RL   BMC Genomics 16:553-553(2015).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KND94272.1}.
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DR   EMBL; LFRF01000002; KND94272.1; -; Genomic_DNA.
DR   EnsemblFungi; KND94272; KND94272; TOPH_01035.
DR   Proteomes; UP000036947; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000036947};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000036947};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    422    446       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    458    483       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    548    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    603       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    648    667       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    791    816       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      101    128       {ECO:0000256|SAM:Coils}.
FT   COILED      279    306       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   865 AA;  98652 MW;  4188EB8A06E486FC CRC64;
     MAPKQDTPFR SAEMSMVQLY VSNEIGREVV TALGELGLCQ FRDLNDDVSA FQRTFTQEIR
     RLDNVERQLR YFNAQMDKAG ISLRKLDLDN ERLASPSTSE IDELAERSQK LEQRVSALND
     SYETLKKREG DLTEWRWVLR EAGSFFDRAH GNVEEIRASA DNDDAPLLSD IEQHNSAPEV
     ERSFSGMNIG FVAGVIARDR VAAFERILWR TLRGNLYMNQ SEIPEPLIDP TNNEAVNKNV
     FVIFAHGKEI LAKIRKISES MGAEVYNVDE NSDLRRDQIH EVNNRLEDLQ NVLHNTQTTL
     EAELNQISQS LSAWMVLIAK EKAVYSTLNL FSYDRARRTL IAEAWCPTND MPLIRSTLQD
     VTNRAGLSVP SIINEIRTNK KPPTYLKTNK FTEGFQTIVN AYGTATYQEV NPAMPVIVTF
     PFLFAVMFGD FGHAIIMLAA ALAMIYWEKS LKKVTFELFA MIFYGRYIAL VMAVFSVFTG
     LIYNDVFSKS MTLFTSAWEF RKPDNWKDGM SIDADLNKVG YRYPFGIDSA WXGTDNDLLF
     SNSYKMKMSI ILGWAHMTYS LCFAYINARH FKKPIDIWGN FVPGMIFFQS IFGYLVICII
     YKWSVQWIDW TLPEPKMIAQ PPGLLNMLIY MFLQPGHLDM RLYSGQEIVQ VALLLLAVVQ
     VPILLFLKPL YLRWEHNRAR AKGYRGIGET SRVSALDGDD EHETLVNGHG DSFDEDGEGV
     AMISQNIDEE HDEFDFSEVM IHQVIHTIEF CLNCVSHTAS YLRLWALSLA HQQLSVVLWD
     MTLGSALKTP GVTGVIMIVA CFYLWFFLSI AILVCMEGTS AMLHSLRLAW VESFSKFAEF
     AGWPFAPFSF GTLLEESEDL KDYLG
//
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