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Database: UniProt
Entry: A0A0L0W6W4_CLOPU
LinkDB: A0A0L0W6W4_CLOPU
Original site: A0A0L0W6W4_CLOPU 
ID   A0A0L0W6W4_CLOPU        Unreviewed;       445 AA.
AC   A0A0L0W6W4;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   05-JUL-2017, entry version 15.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KNF07298.1};
GN   ORFNames=CLPU_19c00340 {ECO:0000313|EMBL:KNF07298.1};
OS   Clostridium purinilyticum.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Gottschalkia.
OX   NCBI_TaxID=1503 {ECO:0000313|EMBL:KNF07298.1, ECO:0000313|Proteomes:UP000037267};
RN   [1] {ECO:0000313|Proteomes:UP000037267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1384 {ECO:0000313|Proteomes:UP000037267};
RA   Poehlein A., Schiel-Bengelsdorf B., Bengelsdorf F.R., Daniel R.,
RA   Duerre P.;
RT   "Draft genome sequence of the purine-degrading Gottschalkia
RT   purinilyticum DSM 1384 (formerly Clostridium purinilyticum).";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KNF07298.1}.
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DR   EMBL; LGSS01000019; KNF07298.1; -; Genomic_DNA.
DR   RefSeq; WP_050356383.1; NZ_LGSS01000019.1.
DR   EnsemblBacteria; KNF07298; KNF07298; CLPU_19c00340.
DR   PATRIC; fig|1503.3.peg.846; -.
DR   Proteomes; UP000037267; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000037267};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037267}.
FT   DOMAIN      140    268       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      352    421       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     148    155       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   445 AA;  50264 MW;  794C38D19EA36BD3 CRC64;
     MGLNLDEIWI SSLKLIKSEL TDVSFNTWLK TIEPITINDN NIVLGAPNEF TKGILEARYL
     TLIKNALKQV SGTDFEVSFL IPGEEISSDV EQPSSNPIND INSSRSQLNP KYTFDTFVIG
     NSNRFAHAAS LAVAEAPAMA YNPLFIYGGV GLGKTHLMHA IGHYILNQNP KASVVYVSSE
     KFTNELINSI RDDRNVEFRN KYRNVDVLLV DDIQFIAGKE RTQEEFFHTF NALHEANKQI
     IISSDRPPKE IPTLEDRLRS RFEWGLIADI QPPDLETRIA ILRKKAKVEN IDVPNDVTLY
     IASRIQSNIR ELEGALIRVV AYSSLTNREV TVDLATEALK DIISNTKPKE INVKLIKEVV
     SNNMGVKIED FNSKKRTRAI SYPRQIAMYL CRELTDLSLP KIGEEFGGRD HTTVIHAYEK
     ISNNIEKSSE LKSRIEELTK EITGN
//
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