ID A0A0L1I4M1_PLAFA Unreviewed; 786 AA.
AC A0A0L1I4M1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Ecto-nucleoside triphosphate diphosphohydrolase 1 {ECO:0000313|EMBL:KNG74584.1};
GN ORFNames=PFMG_00738 {ECO:0000313|EMBL:KNG74584.1};
OS Plasmodium falciparum IGH-CR14.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG74584.1, ECO:0000313|Proteomes:UP000054562};
RN [1] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283}.
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DR EMBL; GG664993; KNG74584.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L1I4M1; -.
DR EnsemblProtists; KNG74584; KNG74584; PFMG_00738.
DR Proteomes; UP000054562; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 2.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF83; NTPASE, ISOFORM F; 1.
DR Pfam; PF01150; GDA1_CD39; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000313|EMBL:KNG74584.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000054562};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 216
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 246..250
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 786 AA; 94081 MW; 414FDA743642B90B CRC64;
MENLIGTPLI EKKKKESHIS IRKDKKLNDI EGEKKEKKIK ERLFLCLICL LVIIWLIYFC
YKNHIFLSYL QNEKEYGIII DAGSNGTRIH LFEWKKREYE LSNKKEENNL IELKEIFNAK
VKKSISTISY NEIKDILIYL INKVIDHLIE KKIYVYNKQK WKSYPFYFQA TGGMRNLKQE
DRNLRMKYIK NILSNDNYNP FYFLNEYARI LSGEEEGIYG WLAVNNLLNS IFSKPNNTYG
AIDLGGSSTQ ITFYPMDHNI LENYNSILLN NILIRLYSHS FIGYGWIDSL FRVNIYLCLE
IIKKLSTRNI KNIYQLENYY DDYINDYFYN NLPNYNWFFY STKKIINNNK ENYNHHNYEN
INYDVNKRNY PYNNFQQKYI HTNPKKGNYT KGNINNSNKS YKNLSNILLQ EIVKYIQHSQ
NDYPYSSLTD IYDYTYNIYD EKPYDIENFI KTIKNFNRHS KEDTIMLVQN PCLPYPYEMK
ITFPTYNLVT SQFVILKKNS RNEIGNINDI KNDGNNYTQN DDNNYTQNDG NYYRQNVGNY
YRHNHNINDV YELNSSESYD NFISNFVLKL KIINNNMSLM DNIYEDFKNK GYLNNVLKKV
NDNKISNTLK NEIIKRLFEK IINEKIKKLY INITVRIVGS NDFKKCLENT KKLFYEQPCF
LSSCSFNGIY QPNLENNKFV LHGQFKKVIT YLGFKKYVDL NQMKIYIQKL CNMNLYELTY
NMSNKIMHNQ IPTFCWKSIW SYSLLFYGFK FKETTKLLII NDNTNISYDS SSTSQASKQF
YKSTLK
//
