ID A0A0L1I862_PLAFA Unreviewed; 1279 AA.
AC A0A0L1I862;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Patatin {ECO:0000313|EMBL:KNG75672.1};
GN ORFNames=PFMG_01836 {ECO:0000313|EMBL:KNG75672.1};
OS Plasmodium falciparum IGH-CR14.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG75672.1, ECO:0000313|Proteomes:UP000054562};
RN [1] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PLPL family.
CC {ECO:0000256|ARBA:ARBA00006104}.
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DR EMBL; GG665078; KNG75672.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L1I862; -.
DR EnsemblProtists; KNG75672; KNG75672; PFMG_01836.
DR Proteomes; UP000054562; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF66; TRIACYLGLYCEROL LIPASE PTL2; 1.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054562};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 576..772
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 85..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1279 AA; 150101 MW; DF7C7E6858053A21 CRC64;
MKTPEFSLDS LKNNRKKKSK KLNYENWSAH YFLKLPIFVI LMIVFSLNAF IYLLIRFFIY
FFENTSFWMI TKYKDFHFFV RKKRNGKTPS SSSNKRKYND NINNDDEPIL NKNEKDDSIF
QIEHLMNTCN NYDDYIKYAY SMDVLTGKTV HINENDDYIN IYDVHLLKKT SESIQTNLLN
KDILLLLEDI KIATSPRIKG IFQEKYYCKT YSIPHLIVTE FINNVMNGLN FLENYIEQQK
QININYKFSD EYLVIKKYFK DIFRQWGNTA LFLSGGAILG LHHFGVLEVF LKSSINADYF
NHYAKKLTTQ KKIKEEMLPR NSHGNDISND INKKDIHKDS QDKKKKYIIL KSNSNNEKKL
SSGDSDKKKQ NKKKYINRIK QGIKKNIQDN QKEYYDYNNN NGDDYNNNRD DNKNNFDNYN
NNCDNYYNNF DNYNNNFDNY NNNFDNYNNN FDNYNNNCGD HNDFHYDNSS SSNTSVYHSS
ICEDINLFCT DPMIKLKQHN NIKDKKKKSI MNFNILCNNI TNRNGSSNIN NNKVPIKQDG
NLKFNKKDIN MNPDNLKEKQ KNLLFDSLNK FYKDSEQPNK NGNFPLTKNN ENDFVENFED
NILPQIICGT SAGSIVAAWI CTRTNNELLD EFNINFIYNI VSCFSSENWF YSFFNIYKKG
NFYDIDKIVK LIYNLYGDMT FLEAFIKTNL VLNITVTRAE CENNNFSCDE DGHIVLNYMN
SPNVLIYTAV LASCSFPYLL QPFKLLEKKY NKENVYRFMS IKEVNNSKLI LNSNTLYKNR
ILLKEDSDGL ALSRSLESSD IKSEKTCNNH DTWKHNYSNS NHYFNSNINL DDEQKNLNEP
QQAISNNVHN YENKNSSCAT IDTCMKEEYI LSKTILENEF INKPINNNIN KDYMQNNGEV
EFIGKKNHHI LSKNNIKNND NETIASFFVS NNDLNSTGEK SKKKKKIINN NNDDHNNTMD
FQDSLVVHKG DKNDLLVLRE EKKKKDNINK NDMNDYNTCD DNCDVNDDDD DELEDQDDIC
INRVLGNEID GGDILDKEKI KKKKKNNKDT VSIEKKGTVL TDNWENENML IEKTYENGNL
SNKYIDINEY RNINLLNEEY TIINSVQFKN MYFHDGSLKS DIPAHNLNQI LSVKYKIVSQ
VNPHVFPFTG VRVHGEAGKP VKWRGSSGNW RAGFLMSSME ILFKENMRYI LRLMALLDLS
PTIRGLNAGS IAMQNYNGDI TLHPKRLYLK HFKLISVSNY DDVEWYIQQG RQMTFQKLPL
ILNRMKIEKK LIKMKKCFF
//
