ID A0A0L1IFU5_PLAFA Unreviewed; 1151 AA.
AC A0A0L1IFU5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=26S proteasome subunit {ECO:0000313|EMBL:KNG78484.1};
GN ORFNames=PFMG_04593 {ECO:0000313|EMBL:KNG78484.1};
OS Plasmodium falciparum IGH-CR14.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG78484.1, ECO:0000313|Proteomes:UP000054562};
RN [1] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
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DR EMBL; GG665580; KNG78484.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L1IFU5; -.
DR EnsemblProtists; KNG78484; KNG78484; PFMG_04593.
DR Proteomes; UP000054562; Unassembled WGS sequence.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR004155; PBS_lyase_HEAT.
DR InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF01851; PC_rep; 2.
DR Pfam; PF18004; RPN2_C; 1.
DR Pfam; PF21505; RPN2_N; 2.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SMART; SM00567; EZ_HEAT; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Reference proteome {ECO:0000313|Proteomes:UP000054562};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 14..142
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 178..329
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 945..1127
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 364..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1080
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1151 AA; 130239 MW; 2985223D3EC600ED CRC64;
MRFENQFSKH DIVTSASGVI ALLNEEETSL KLFGLEKLNA IVDVYWPELA DSIFKIEELC
EDEDFVGREL ANLLASKIYF HLEKYSEALK YALCAGKLFN IKEKSQYVET MLAKCIEKYV
EIREMQYDID YNNQHNINDG ITNNNDIFNA YNNNDLVELN SHNELLNKET DIFRFDINNE
INQKMELLVD EMIDVCIKSN DIKEALGVAL DARRLDKVEY IIANAENKIE ILAHSINNEK
HINMNKSFRN EYFKLLVNLY LSLSEEELKT EYINLCECLY YIDDYKKVAE ILLKLLHNYH
LMAYQISFDL VDFENKIFLR NILGQIKENL IQNKAYYFGE EYFVTTPQEE NNDADNKENE
SNAITNEQQD ENNNEKEDKD NNDGKNPEHN DDNNKPNDNL TNDEPTYNNN DDKAINDGND
NDNNNNNNIN NNNNNNNNNI VEDVLKYISK KHIFYNKMKK LLYILTGKVT GNLYIEFLHR
NNHADLILLD TYKNIVDSRS SITHHGIVIA HALMQTGTTC DVFLRSNIEW LSKAINWAKF
SATASLGVVY KGHVNESFMV LSTHLPYNDV STEIANNINV GLAPSGVYSE GGSLYALGLI
HANYNTNDKK VKNYLMSQLK SNMNDEVLQH GCCLGLGLVC LGDSNDENTY DELKAILYSD
SAVAGESAAY AIGLLKLGSG DDKCIDELLA YAHDTQHEKI TRACSISLGF VMFQKEREAD
SLIEELVSDK DAIIRYGGMF AIAMAYCGLS NCNKHIIKKL LHFSVSDVSD DVRRAAVIAL
GFVLCNSPNQ VPKFLNLLIE SYNPHVRYGA ALALGIACSA TANEEAINML MPLLTDTTDF
VRQSAFISLG LIFQQSNEHC NPNFKKYKEE IMKILSDKHE DIIAKFGAIV SAGLLDICGR
NAISTFFTRR GNIIRPQAAA GFCLFSQLWY WFPLIHMISL TFMPTCLIGL TEDLKVPKNF
SILSTSNNQN FDYPSFLSKE KTQEKKETVT AVTAQDDNSS VLSDGKSMKN LEILSTAATI
GQSSHVSHAE SVEGSANDEN SHDHAQDGSN ISNVQKGKKS EAKSKSGANE NSNNNTVDMK
NPCRVIKMQE KYIEYIPNSR YIPVLPTRKS GFIMLNDITP LEPSECIEIN FEETSKKEAP
PFEPFSWKEE N
//
