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Database: UniProt
Entry: A0A0L6T546_9BURK
LinkDB: A0A0L6T546_9BURK
Original site: A0A0L6T546_9BURK 
ID   A0A0L6T546_9BURK        Unreviewed;       485 AA.
AC   A0A0L6T546;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-SEP-2017, entry version 15.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AD742_19005 {ECO:0000313|EMBL:KNZ31267.1};
OS   Methylibium sp. NZG.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Methylibium.
OX   NCBI_TaxID=1686064 {ECO:0000313|EMBL:KNZ31267.1, ECO:0000313|Proteomes:UP000053102};
RN   [1] {ECO:0000313|Proteomes:UP000053102}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bi G.;
RT   "Draft Genome Sequences of the MTBE Degrading Bacterium Methylibium
RT   sp. NZG.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KNZ31267.1}.
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DR   EMBL; LGRD01000032; KNZ31267.1; -; Genomic_DNA.
DR   EnsemblBacteria; KNZ31267; KNZ31267; AD742_19005.
DR   PATRIC; fig|1686064.3.peg.3701; -.
DR   Proteomes; UP000053102; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053102};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053102}.
FT   DOMAIN      182    316       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      393    462       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     190    197       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   485 AA;  53861 MW;  422FF9597CE9AB0C CRC64;
     MSADLWQRGC ERLAAELPEQ QFNTWIRPLP VADVSEEGDA GAVVTVRVPN RFKLDWIRNQ
     YAGRIEAVLS EIAGKPVRLD MTLAPREGLP AMVAVAGNSL RPVGAFVPRP AMPPVVPTVV
     PINGDRRRNG DAPAGAHAPS VSVLPSRSRL NTGLSFNTLV PGRANQMART AALHVAGAPG
     QMYNPLFIYG GVGLGKTHLI HAVGNALLAD KPDARILYLH AEQFITDVVK NYQRKTFDEL
     KAKYHSLDLL LIDDVQFFAG KERTQEEFFN AFEALLAKRA HIIMTSDTYP KGLVDIDERL
     TSRFDAGLTV AIEPPELEMR VAILMRKAEL EATMMPEDVA FFVAKNVRAN VRELEGALRK
     ILAYSRFSQK EITIALAREA LKDLLSIQNR QIGVENIQKT VADFYKIKIA DMYSKKRPAS
     IARPRQIAMY LAKEMTQKSL PEIGELFGGR DHTTVLHAVR KIGAERQKNP ELNQQLHVLE
     QTLKG
//
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