ID A0A0L6TCX2_9BURK Unreviewed; 1030 AA.
AC A0A0L6TCX2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Lactate dehydrogenase {ECO:0000313|EMBL:KNZ34004.1};
GN ORFNames=AD742_00725 {ECO:0000313|EMBL:KNZ34004.1};
OS Methylibium sp. NZG.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Methylibium.
OX NCBI_TaxID=1686064 {ECO:0000313|EMBL:KNZ34004.1, ECO:0000313|Proteomes:UP000053102};
RN [1] {ECO:0000313|Proteomes:UP000053102}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bi G.;
RT "Draft Genome Sequences of the MTBE Degrading Bacterium Methylibium sp.
RT NZG.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNZ34004.1}.
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DR EMBL; LGRD01000002; KNZ34004.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L6TCX2; -.
DR STRING; 1686064.AD742_00725; -.
DR PATRIC; fig|1686064.3.peg.12; -.
DR Proteomes; UP000053102; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR004017; Cys_rich_dom.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR PANTHER; PTHR11748:SF119; D-2-HYDROXYGLUTARATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR Pfam; PF02754; CCG; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022827};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053102}.
FT DOMAIN 62..290
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT DOMAIN 662..692
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 110599 MW; 24374FCE158CDB49 CRC64;
MTSPSTASAA PAAPARPAPL GTVLPPNEVC AELAKRLRAD TEGEVLFDAA SRGRYATDAS
IYQIMPASVL VPRTERDIAV ALQVARELKV PVLPRGGGTS QCGQTTGAAL VIDHSKHFRK
LLRLDVAGRT AEVEPGMVLD HLNAHLKAHG LWFPVDVSTS AQATLGGMAG NNSCGSRSIA
YGNMVHNVLG ARAWLADGAL LDFGPVATLG VREAKIAQFV RQLAVEHRND IHAHWPKVMR
RVAGYNLDIF DNQSERPYTP DGSVNLAHLL VGSEGTLACT RSLTLKLAEL PRAKVLGIVN
FPSFRAAMEA AQHIVTLGPT AVELVDRTMI ELSLGNPAFR PTVETALIGR PAAILLVEFC
GETSAELLPK LKQLDELMGD LQLPGSVVHM HDAAAQKNLW EVRKAGLNIM MSLKGDGKPV
SFIEDCAVPL EHLADYTDAL TEVFARHGTR GTWYAHASVG TLHVRPILDM RSGGEHAGAA
KMRAIAEEAA VLVRQYKGAF SGEHGDGLCR GEWIEWQFGP AINQAFRAIK NELDPAGLFN
PGKIVDPPKM DDVSLFRFCP PTAPQPYRRI AITPVLDWSA WNVQADAVTE ATTAPGTGFD
ATGGLAMAVE MCNNNGHCRK FDAGTMCPSY RVTRDEQHLT RGRANTLRLA LSGQLGADAF
TSESMHDTMD LCVGCKGCKR ECPTGVDMAK MKIEFLAHYK ARHGHTLKDR LIANLPNYAA
RASRVPWLMN LRDTVPGAAW LSEKWLGLSK ARKLPRWRSD TFWRSDDLWM FASAEQTLAA
AAAGEKAAVL FVDTFNGSFE TENALAAADV LNAAGYTLHT VTKAGGHHCC GRTFLAAGMV
EQAKASVGAL IDALLPFAQA GIPIVGLEPS CLLTLRDEAL VMGLGERAEV VAAQALLVEE
FIAREAGAGR WSLALRSADA PILLHGHCHQ KAFGAVEPIL DVLRLIPGAA PELIESSCCG
MAGSFGFDAA HHAVSMQMAE LSLLPAIRQR PDAIVVADGT SCRHQIEGGA QREAMHVVRL
LASLIDRRGD
//
