ID A0A0L6WKU3_9AGAR Unreviewed; 936 AA.
AC A0A0L6WKU3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=J132_11382 {ECO:0000313|EMBL:KNZ76160.1};
OS Termitomyces sp. J132.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Tricholomatineae; Lyophyllaceae;
OC Termitomyces.
OX NCBI_TaxID=1306850 {ECO:0000313|EMBL:KNZ76160.1, ECO:0000313|Proteomes:UP000053712};
RN [1] {ECO:0000313|Proteomes:UP000053712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J132 {ECO:0000313|Proteomes:UP000053712};
RA Hu H., Poulsen M.;
RT "The genome of Termitomyces.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the WD repeat BUB3 family.
CC {ECO:0000256|ARBA:ARBA00037960}.
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DR EMBL; KQ412594; KNZ76160.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L6WKU3; -.
DR STRING; 1306850.A0A0L6WKU3; -.
DR OrthoDB; 121154at2759; -.
DR Proteomes; UP000053712; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd09616; Peptidase_C12_UCH_L1_L3; 1.
DR Gene3D; 3.40.532.10; Peptidase C12, ubiquitin carboxyl-terminal hydrolase; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001578; Peptidase_C12_UCH.
DR InterPro; IPR036959; Peptidase_C12_UCH_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10971:SF5; MITOTIC CHECKPOINT PROTEIN BUB3; 1.
DR PANTHER; PTHR10971; MRNA EXPORT FACTOR AND BUB3; 1.
DR Pfam; PF01088; Peptidase_C12; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00707; UBCTHYDRLASE.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00140; UCH_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000053712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 478..519
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 617..658
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 787..803
FT /note="Ubiquitin carboxyl-terminal hydrolase family 1
FT cysteine active-site"
FT /evidence="ECO:0000259|PROSITE:PS00140"
SQ SEQUENCE 936 AA; 103151 MW; 16E3CB83C8128CAD CRC64;
MEDLVAGMTV SASNIAKASD TTKHPPCKLS VMTEVKCGDG CGSEGSANCG DIGMAGPSTP
KHAAGSVAKG LEMLPRLATT PKGKGKSKAN AREEEEEEFE LNSLVNKVLQ LNVFPFWVPV
GVLRIFVKNF AHCTNLTELM HVGILFNLAQ TRLMPSETLL KLYKLLQPSN PISNNSNNSV
YEDWIDCLHG FIYQVQLPLP LLCQVSSASQ LLPPLLEFQP LQPLATFISN DSNDTALQLA
NSDDILLLCN DGTTTYNNVP HSAKTIASDA CLLLVKKWLN NLARPEGLSD TEYATFICYA
LMFFITGGKL WQRDRDGTHK LFVPTNYHLQ VLKAIHDNLG HKGLFAFHSA LLECFWGRSN
GEGWTKFVDS NSDDLNKLSS LRMNDEQITL PSPPFDSISS VRFSPTNPDH LLASSWDATV
RLYEVGDKEG NEGEGKAKFD HRAPVLACCF SDATHAFSGG LDTSVRELDL GTENMRNLGA
HNDSISTMTY FRESNTLITG SWDRTLRFWD SRASSPQQSS HDTPERVYQI DLVNNTLVVA
MASRLFNIYD IRKMDAPLQQ RESSLKFMTR SLACMPDGEG YATASVEGRI AVEYFDPSPV
VQEKKYAFKC HRQTINDVDH VWPVNALAFH PTYNTFASAG SDATVSIWDH KVKKRLRQYP
KFASSISSLA FNSDGTKLAI AVSYTWDDGE PGLKTAERPA ILVRKLGDEV KPKGWTEKAG
LVLSQAQFED VYGLDPELLA MVPQPVKAVV LLFPISEALE NKRKEEDEKI KNAGQPHLDP
TILWIKQTIS NACGTIGLLH ALANSDATFS PESPIAQFID ECKDRTPEAR AKLLETTPLF
ANIHAQAASS GQTQVPTDLD TDLHFTCFVP APVVRGPESP GGYRIVELDG RRAGPVDRGE
CKNSFLEEVA KVVKEIYLAN TSSMQFSMVA LCPSPE
//
