GenomeNet

Database: UniProt
Entry: A0A0L7LHR2_9NEOP
LinkDB: A0A0L7LHR2_9NEOP
Original site: A0A0L7LHR2_9NEOP 
ID   A0A0L7LHR2_9NEOP        Unreviewed;      1955 AA.
AC   A0A0L7LHR2;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   10-MAY-2017, entry version 11.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE   Flags: Fragment;
GN   ORFNames=OBRU01_07007 {ECO:0000313|EMBL:KOB75098.1};
OS   Operophtera brumata (winter moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
OC   Geometroidea; Geometridae; Larentiinae; Operophtera.
OX   NCBI_TaxID=104452 {ECO:0000313|EMBL:KOB75098.1, ECO:0000313|Proteomes:UP000037510};
RN   [1] {ECO:0000313|EMBL:KOB75098.1, ECO:0000313|Proteomes:UP000037510}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM2013NL {ECO:0000313|EMBL:KOB75098.1};
RC   TISSUE=Head and thorax {ECO:0000313|EMBL:KOB75098.1};
RX   PubMed=26227816; DOI=10.1093/gbe/evv145;
RA   Derks M.F., Smit S., Salis L., Schijlen E., Bossers A., Mateman C.,
RA   Pijl A.S., de Ridder D., Groenen M.A., Visser M.E., Megens H.J.;
RT   "The Genome of Winter Moth (Operophtera brumata) Provides a Genomic
RT   Perspective on Sexual Dimorphism and Phenology.";
RL   Genome Biol. Evol. 7:2321-2332(2015).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KOB75098.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JTDY01001023; KOB75098.1; -; Genomic_DNA.
DR   Proteomes; UP000037510; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 6.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000037510};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KOB75098.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037510};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    146    171       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    183    201       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    207    226       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    337    359       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    732    755       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    776    799       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    805    829       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    841    858       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    864    883       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    928    951       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1008   1029       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1285   1304       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1324   1343       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1350   1373       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1404   1422       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1443   1472       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1559   1584       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1604   1622       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1634   1652       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1664   1683       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1727   1750       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1820   1840       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1857   1892       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED       24     49       {ECO:0000256|SAM:Coils}.
FT   COILED      356    412       {ECO:0000256|SAM:Coils}.
FT   NON_TER    1955   1955       {ECO:0000313|EMBL:KOB75098.1}.
SQ   SEQUENCE   1955 AA;  222280 MW;  65CC5DFFBCAF5E20 CRC64;
     MSEDLDSISE EERSLFRPFT RESLAVIEAR IAEEHAKQKE IEKKRAEGEV RYDDEDEDEG
     PQPDATLEQG LPLPVRMQGT FPAELSSTPL EDIDPYYINC ILMIMPSTPT VESTEVIFTG
     IYTFESAVKV MARGFILQPF TYLRDAWNWL DFVVIALAYV TMGIDLGNLA ALRTFRVLRA
     LKTVAIIPGL KTIVGAVIES VKNLRDVIIL TMFSLSVFAL MGLQIYMGVL TQKCVKVFPE
     DGSWGNLTDE NWERFCQNET NWYGGGGDYP LCGNSSGAGQ CEPGYICLQG YGPNPNYGYT
     SFDTFGWAFL SAFRLMTQDY WENLYQLVLR SAGSWHVLFF VVIIFLGSFY LVNLILAIVA
     MSYDELQKKA EEEEQAEEEA LREAEQKAAA RADKQEAREA HARDQAAAAE AAAYAEAHPA
     KSPSDFSCQS YELFVNQERG NQDDNTRERM SLRSDPFQDS VSTQPTHKPN ETHHEARRPR
     KVSMVPHPER INKIGHVSYG PLREGSQASL SLPGSPFNLR RGSRGSHQMT LRPNGRNRYP
     PGADRKPLVL STYLDAQEHL PYADDSNAVT PMSEENGAII IPVYYANLGK AQTKEAKLRG
     RSASRNHSVT SQPHAYPLPR QDSSLASRPL REYEMSTTEC TDEAGKVIKP SGDNPFIESS
     QQPNVVDMRD VMVLNEIIEQ AGRQSRTSEQ NADDDEDGPT FKERFLEFGM KAIDFFCVWD
     CCWLWLEFQK YVALLVFDPF VELFITLCIV VNTLFMALDH HDMDKDMERA LKSGNYFFTA
     TFGIEALLKL VAMSPKFYFQ EGWNIFDFII VALSLLELGL EGVQGLSVLR SFRLLRVFKL
     AKSWPALNLI ISIMGRTVGA LGNLTFVLCI IIFIFAVMGM QLFGKNYVGK DAVVWEELHR
     FNLRVFKLAK SWPTLNLLIS IMGRTMGALG NLTFVLCIII FIFAVMGMQL FGKNYVDNVD
     RFPDGDLPRW NFTDFMHSFM IVFRVLCGEW IESMWDCMLV GDVSCIPFFL ATVVIGNLVV
     LNLFLALLLS NFGSSSLSSP TADQETNKIA EAFNRISRFT DWIKRNVADF LKILKNKLTN
     QIAIHAPERV DNELELGTDL DDAVLYKDKK LKDQVEVAIG DGMEFTIPGD NKYKKGKILM
     NNINAITDNH RDNRLDCELN HHGYPVQDDD TISQKSYGSH KLRSFKDESH KVSADTIDGE
     EKKDASKEEL GLEEEMIEDE EDGKLDGLKD IKVEADEEVV DDSPAECFPE PCYKRFPFLA
     GDDESPFWQG WGTLRLKTFK LIENTYFETA VITMILLSSL ALALEDVHLP HRPILQDILY
     YMDRIFTVIF FIEMLIKWLA LGFQKYFTNA WCWLDFVIVM LSLVNHGAVM AGADDIPAFR
     SMRTLRALRP LRAVSRWEGM RVSLINFVAA LCGAGGIQAF KTMRTLRALR PLRAMSRMQG
     MRVVVNALVQ AIPSIFNVLL VCLIFWLIFA IMGVQLFAGK YFKCVDMNHT TLSHEIIPDK
     NACVLENYTW ENSPMNFDHV GKAYLCLFQV ATFKGWIQIM NDAIDSREVG RQPIRETNIY
     MYLYFVFFII FGSFFTLNLF IGVIIDNFNE QKKKAVTDKK FDMIIMLFIG FNMLTMTLDH
     YQQAKGFSDV LDCLNALFIV IFSSECLLKI FALRYHYFVE PWNLFDFVVV MFSILSLVLS
     DIIEKYFVSP TLLRVVRVAK VGRVLRLVKG AKGIRTLLFA LAMSLPALFN ICLLLFLVMF
     IFAIFGMSFF MHVKDKGGLD DVYNFKTFVQ SMILLFQMST SAGWDGVLDG IINEEECDLP
     DNERGYPGNC GSATIGITYL LSYLVISFLI VINMYIAVIL ENYSQATEDV QEGLTDDDYD
     MYYEIWQRFD PDGTQYIRYD QLSEFLDVLE PPLQIHKPNK YKIISMDIPI CRGDNMFCVD
     ILDALTKDFF ARKGNPIEET GDLEPGRPNE IGYEP
//
DBGET integrated database retrieval system