ID A0A0L7M659_PLAF4 Unreviewed; 1859 AA.
AC A0A0L7M659;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Leucine-rich repeat protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFDG_01735 {ECO:0000313|EMBL:KOB88329.1};
OS Plasmodium falciparum (isolate Dd2).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57267 {ECO:0000313|EMBL:KOB88329.1, ECO:0000313|Proteomes:UP000054282};
RN [1] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Kodira C., Zeng Q., O'Leary S., Yandava C., Alvarado L., Wirth D.,
RA Volkman S., Hartl D.;
RT "The genome sequence of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG701620; KOB88329.1; -; Genomic_DNA.
DR EnsemblProtists; KOB88329; KOB88329; PFDG_01735.
DR VEuPathDB; PlasmoDB:PfDd2_060017100; -.
DR OMA; GDDNNHY; -.
DR Proteomes; UP000054282; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR15454:SF56; LRRCAP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15454; NISCHARIN RELATED; 1.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000054282};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REGION 410..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1181..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 821..848
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1059..1089
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1491..1549
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1722..1835
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 410..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..493
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..652
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..686
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1859 AA; 219587 MW; 8A0DCB278AE5B864 CRC64;
MLLDLSNNKL KSLEDCDIIL EKLIELNLDY PSITYLNVSH NNIKSIKGLR AFENLRVLNI
SHNEVISLDD DYIPCCTEKI IADHNLLTDI CFKGIEKVEE EYDEDICEEN NSYEKCNNEN
VYKGNDNDND DINCNNNFYC DEDDNILCGK DIIKNKTKNY KKNNYHNEQE KRNQHNNNHE
KKKVTRNRSI YDSFNSNILN EKNMYTNKNL PLNKLIYLDV SYNNIKKLTT FEKYLHIINK
NKREKNDSCS DDAYMNNFIS NKTEQDVMIL FFNSLETLHL RGNQLTNLKG LSVFKNLKVL
DLRSNFINHP VQLFYILDNK NWLKKYQKNK MERKDTNYYS YFVYILKKYK NFKNLQNLFL
QGNNKVLKPK YLFMSVYNVL KNINVKRKLS TDVITDNLSL DVSKKKKKNN FVHNGESDDE
RNEAGRYVDC EGENKKYDEV EEGEEYEDEN EGEDEGEDEG EDEGEDEGED EEEDEEEDEE
EDEEEDDDFI NYVEEENYSL NPKNKKKGTE LNDRLEEKEI LDEKIKKDKV DDHNINEYKE
NIKNCPNDRD EEESFYEDDS SNEYTYIMEK MGKSFNKINK LENNKNTNNY LSDITYEEKE
VYDDTSQDNG ESNINRSSKC SPLYSEDDTE IESNEEEEYA LIRKRNNKEN EEEGYDGDDN
NKDGDDNNND GDDNNDGDDN NNDGDDNNND GDDKNYYGDD NNHYGDDNNH YGDDNNHYGD
DNNHYGEEKK VKEKDKSLFI KDTFNNKNLY SCKTREKKFL YSINEDEDEK KIDDLIKHIS
YNVSRNSSNI MSSQNSWKKN QECIKLKSCD NNKREFVWDN NQTEENQVQN KNRERDNIKK
KILNTKEKNY ISEESNVSYV EKANNCKKNI YKYIKSNDNI NKSLVKEKKK NIFPSCERHN
EEYLNEKINN RNTNNNININ HENNNILNTK ERCSYTKHCH KNDTENNKIK KNKMEITINS
LHKTYKQKEG RNICFPSVFK ENKKTNDVLK EILYKNRDMD KSTLTNFSSM EESDMFDSDC
EEIMLTSNSD LININKENMN KEKINKENVN KEKINKEKIN KEKINKEKIN KENMNKENMN
KENMNKENIH MDDYNIHNCN IKELSNFSDK NKNHSSSKQK GNSNPLTINY GKEDKYNMDD
HKKMIGTIEK MIEYKNSKEK GIIDDGDICI SKQENEHGIF NEKRNKEQLN KQGTNGSMNG
GTNGSRDGGT NGGTNGGTNG NMNGNKDKYQ MEDSLYNDEE KKEVCNILNI SYRKNKTNYC
DDNNLKTEKC NIQRNVKNEM NISYSNQDIC IYKIEEGKEN VTYKCNNKNK LPMSNPQNRK
LYHACSSFKS ESTDVTERTM NMDKKLIIKK NILNNDSLNI NNMKNIKDLI ISKNMINIQQ
AYPIHIQNNK ETKNWNKKEE HDHNMSSIIK DTLLVEKKKV PKNEDINDYI NEKKNQSIIK
RNDLSQNNHK GTCIKNVQDV NILKDTEKYN DKNSMLCNNL ALYLKDACLN LGKEKQYTNN
LLEQKKKLEN EIKIMNAQKD IYKKKIKNLE KLCIEKNKIT KKYKNMNNTF KSFEHMKIEV
PKGDMHSQNE YIENTMEKLY NVFFDAFGEE HIITKMIESL ADVYIKKEKN TEMKMIEHKK
ELDLLKNVEE IVKKKDQYYN ELLKKNEIIK SLNINLNNIT KSVADMKKSI IENENKSRAL
LMELSKKDSI LKDMEKKILL MKGKEKEFEI ERAKIMELLK DNDGNVKSIK EYKDEVKALE
EKLKIYIDKS KNKMNDKNYE KMVDKLHDEQ IKIHSLLTEK EKIINEKNIQ INHLENQLQS
WADEATNWVV MADKHAKLIT KHNILKKNYE ELKLKYIMDM KYIQSNKNEK VKELIKRFS
//
