ID A0A0L7M7H8_PLAF4 Unreviewed; 2013 AA.
AC A0A0L7M7H8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Plastid replication-repair enzyme {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFDG_03594 {ECO:0000313|EMBL:KOB88781.1};
OS Plasmodium falciparum (isolate Dd2).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57267 {ECO:0000313|EMBL:KOB88781.1, ECO:0000313|Proteomes:UP000054282};
RN [1] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Kodira C., Zeng Q., O'Leary S., Yandava C., Alvarado L., Wirth D.,
RA Volkman S., Hartl D.;
RT "The genome sequence of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG701764; KOB88781.1; -; Genomic_DNA.
DR EnsemblProtists; KOB88781; KOB88781; PFDG_03594.
DR OMA; HECLIFP; -.
DR Proteomes; UP000054282; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08639; DNA_pol_A_Aquificae_like; 1.
DR CDD; cd01029; TOPRIM_primases; 1.
DR CDD; cd01122; Twinkle_C; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 3.40.1360.10; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR027032; Twinkle-like.
DR PANTHER; PTHR12873; T7-LIKE MITOCHONDRIAL DNA HELICASE; 1.
DR PANTHER; PTHR12873:SF0; TWINKLE MTDNA HELICASE; 1.
DR Pfam; PF13481; AAA_25; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56731; DNA primase core; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51199; SF4_HELICASE; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000054282};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..2013
FT /note="Plastid replication-repair enzyme"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005574051"
FT DOMAIN 376..460
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT DOMAIN 682..931
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
FT REGION 1042..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 310..348
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1646..1691
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1042..1070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2013 AA; 235388 MW; BB3DE731C808E688 CRC64;
MLLYKFYFLY FLPVHLSLCI RYRNQNKTDS YLKTNYKLLK KRKKYENRRY KFPKNRKGNN
NNIYDAINNN NTNNIYNNDT YKNRIFFRNE KNDENFIKTN KYSYYEKRNK IKLNSATSTF
VSKYYKININ DVYNYLHRKK YEFIETDIKI TLKYCPFCPP HKYKYDNMYK HEIFKNTGNS
YCHRCGYKGS FYDFKLKMGD LITSNFESTV VHNNNFYEEE EEKITLNDVK VYNMNLLYSK
EAENARNYLM NVRKLSIDTL KKFLIGFSVM EFQSFESSGK FEKHECIIFP FIKKVDEINM
IETNGINSNM NKMNNNNNNN NNNNNNNNNN INDNYEVVRI KIRSLKDKGY MRLYPKNVRN
EMKLFFFGDH LIKNSEEIVL TEGEIDAMTI SQETKYPAIS LPNGSKSLPI YLLPYLERFK
KIHLWLDFDK AGKSSVFNFV NKIGLGRTNV ITDANVHYLN PDVFKRRQKS RLTKKSLLLT
SMASNAMEIL QKDKEENMHN IYDTTNNDYM DNKILSNNLK SISSDKIKKK EEIDLFNGQK
ISSNNINVNI LKNKKNETDN ITNKENKSDN NLKEGMEKKE IQNEISVIED NNNNKNNIIE
NNNDDMSEKI KVEKSIEDNI SYFVDNNIMY IPNNIIIKDA NDCLKHNIDI RFFIETSEKV
KHSQILNFND LRQRILEELK YPDRINGVKS KTIPSLNKYL YGLRMGELSI WTGSTGVGKT
TLLSQLSLDY CIQGVSTLWG SFEINNVKLG KVMLNQFCGK NLEKNIELFD IYADKFELLP
LKFLKFHGST NIDQVIDAMD YAVYAYDVKH IIIDNLQFML NINKFSDIYE LQNIAIDKFR
SFSTNKNVHI TLVVHPRKED NNLLSISSVF GSVKSTQEAD NVFIIQRHVS KTNETVFFID
IKKNRFKGSL GKIPYLYNKE NMTIKEISIN NFNEHVVSNT YLPSNKFSSS SLQNNTTNNN
FIQNDNLNFT LCDEYDYMKQ LADEYESKHA FKKGYRSKLD PNLRVNNIDM IKTEIIDNSD
MNNNKNVTLY VDSLENIKTI STDDKTNDDK RDVNEIKSIK NNERKNTLKI DGNKSLGSTQ
NLNYENENKN NNNNNNNNNK SNQEMEKNNI DDKSSTGNNK NINGNSKGNN NINNNNKNKN
SSSSSSSSNY NNNEGIKNIL NTSAQNNIPF KDTISSYTLT NEGLIKLCEE LKDEEAEKLK
NRVVVLSMRN CIIDNNSSIK DIRTFIKTNK LNIKTAGKNL KKMDIFISIL QNIPKEYITI
KSGQKYGPNK GLPNDKSKNK IKEPHNNNML EYNKVGSNIG DGQNTSSSCM NINKIYSEEE
NNIYINNNNN NMNKEPQTLL PNDRNDSNSH SYNNINYTMV KNGNEGNIND YLNRNYENNV
DNHHNDEITK KYIKDNIINV DDNIIKKKDI FKLKNENNEI TECAFEYFES KKKFDDDIES
RFFIINDNNY NENINLIYKD IKYCGLDIET TGLEVFDENI RLIQIAVENY PVIIYDMFNI
NKKDILDGLR KVLENKNIIK IIQNGKFDAK FLLHNNFKIE NIFDTYIASK LLDKNKNMYG
FKLNNIVEKY LNVILDKQQQ NSVWNNSLLN NNQLFYAARD SSCLLKLYKK LKEEIKKENL
HIVNDIENKC ILPICDMELN GIKVDLENLQ KSTNEILNEL NIEKDNLKKK LKDENINVNS
QQQVLKALQK NNVRDISNKL IENTSDSNLK NFLNHEEIIS LRNYRRLYKL YSAFYLKLPL
HINTKTNKIH TTFNQLKTFS GRFSSEKPNL QQIPRQKNIR EIFIPNDNNI FIIADFKQIE
LKIAAEITND EIMLKAYNNN IDLHTLTASI ITKKNIPDIN KEDRHIAKAI NFGLIYGMNY
VNLKNYANTY YGLNMSLDQC LYFYNSFFEH YKGIYKWHNQ VKQKRALQYS TLSNRKVIFP
YFSFTKALNY PVQGTCADIL KLALVDLYDN LKDINGKIIL CVHDEIIIEV NKKFQEEALK
ILVQSMENSA SYFLKKVKCE VSVKIAENWG SKD
//
