ID A0A0L7QLS8_9HYME Unreviewed; 572 AA.
AC A0A0L7QLS8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 08-NOV-2023, entry version 37.
DE SubName: Full=Frizzled {ECO:0000313|EMBL:KOC59603.1};
GN ORFNames=WH47_11345 {ECO:0000313|EMBL:KOC59603.1};
OS Habropoda laboriosa.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Habropoda.
OX NCBI_TaxID=597456 {ECO:0000313|EMBL:KOC59603.1, ECO:0000313|Proteomes:UP000053825};
RN [1] {ECO:0000313|EMBL:KOC59603.1, ECO:0000313|Proteomes:UP000053825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0110345459 {ECO:0000313|EMBL:KOC59603.1};
RA Pan H., Kapheim K.;
RT "The genome of Habropoda laboriosa.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; KQ414905; KOC59603.1; -; Genomic_DNA.
DR RefSeq; XP_017796153.1; XM_017940664.1.
DR AlphaFoldDB; A0A0L7QLS8; -.
DR STRING; 597456.A0A0L7QLS8; -.
DR EnsemblMetazoa; XM_017940664.1; XP_017796153.1; LOC108577504.
DR GeneID; 108577504; -.
DR OrthoDB; 5483535at2759; -.
DR Proteomes; UP000053825; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15034; 7tmF_FZD1_2_7-like; 1.
DR CDD; cd07458; CRD_FZ1_like; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF47; FRIZZLED; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053825};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..572
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005574712"
FT TRANSMEM 239..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..147
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 237..555
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DISULFID 33..94
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 41..87
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 108..132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 572 AA; 64487 MW; A058287BBB663426 CRC64;
MILCYPTIYV LSVVVLGVNA LHAKDPLAHH GRCEPITINL CMNIPYNETI MPNLMNHQKQ
EDAGQEVHQF APLVKMKCSP VLRFFLCTVY APVCTIIDRA IPPCRSLCES ARAGCERLMN
SFDFAWPDNL DCSKLPENGG PELCVGHNET TPPEPSPPAY SPPLMPVAEF QPSWTGGAKP
YGSGYMLGAR DFGFVCPMHF KVPQELGYSL KVGDKVEPNC GAPCDGMFFT ERERRFSRIW
VGTWASVCAA SCFFTFLTFL IDTDRFRYPE RPIIFLSVCY LMVALAYVIG WAAGNSISCR
EPFPPPLDMR IQMTSTITQG TKHELCTVLF MILYFFGMAS SIWWVILTLT WFLAAGLKWG
HEAIEANSQY FHLAAWAAPA IKTVTILAMG KVEGDILSGV CYVGLWNVEA LRGFVLAPLC
VYLVLGTAFL LAGFVSLFRI RTVMKHDGTK TDKLEKLMIR IGIFSVLYIV PALIVIACLF
YEQAYFDQWM LTWNMEMCSR PGPQALYSMP CPVGERTRDV GRRPEFEVFM IKYLMAMIVG
ITSSFWVWSS KTLTSWRQFF NHIQGRQTEA YV
//
