ID A0A0L7QT86_9HYME Unreviewed; 1072 AA.
AC A0A0L7QT86;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Furin-like protease 2 {ECO:0000313|EMBL:KOC61847.1};
GN ORFNames=WH47_05574 {ECO:0000313|EMBL:KOC61847.1};
OS Habropoda laboriosa.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Habropoda.
OX NCBI_TaxID=597456 {ECO:0000313|EMBL:KOC61847.1, ECO:0000313|Proteomes:UP000053825};
RN [1] {ECO:0000313|EMBL:KOC61847.1, ECO:0000313|Proteomes:UP000053825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0110345459 {ECO:0000313|EMBL:KOC61847.1};
RA Pan H., Kapheim K.;
RT "The genome of Habropoda laboriosa.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
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DR EMBL; KQ414751; KOC61847.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L7QT86; -.
DR STRING; 597456.A0A0L7QT86; -.
DR Proteomes; UP000053825; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 9.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR42884:SF23; FURIN-LIKE PROTEASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 2.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00261; FU; 10.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000053825};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT TRANSMEM 1009..1036
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 280..437
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 40..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 22
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 61
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 203
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1072 AA; 115939 MW; 38DB4A66C8E0386A CRC64;
MNLGPAWQKS YTGKGVVVSI LDDGIQTNHP DLALNYDHQA STDINDNDND PMPRDNGDNK
HGTRCAGEVA AVAFNQYCGV GVAYNASIGG VRMLDGPVND AVEARGLGLN PDHIDIYSAS
WGPEDDGKTV DGPGPLARRA FIYGVTSGRK GKGSIFVWAS GNGGRHTDSC NCDGYTNSIF
TLSISSATQG GYKPCTVEHT GTSASAPLAA GIAALALEAN PSLTWRDMQY LVVLTSRSGP
LEKEPGWILN GVKRKVSHKF GYGLMDAGAM VNLAEQWTNV PPQHICKSDE ISEERRIDPT
YGYTLSVYMD VTGCAGSLNE VRFLEHVQCK VSLRFFPRGN LRLLLTSPMG TTSTLLFERP
RDVLSSSFDD WPFLSVHFWG EKADGILKKW QLIFYGTAIN PIRKRTRQFN PGYQGPYVGA
ASNVQASVAT LDGSSAPILT NRLPGDTSSS FDSPASSSQV GDDSLDTTRK ILHDCDPQCD
PQGCYGKGPT QCIACKNYRL DNTCVSRCPP RSFPNQGGVC WPCHESCEIC AGAGQDSCLS
CAPAHLRVTD LAVCLQQCPE GYYENTENST CVPCEANCAS CQDRPDKCTS CEHHLVMYEN
KCYAACPLYT YETQDYNCAP CHSTCETCNG TAENQCISCR PGLFSLNGTC RASCQVGYSA
DKKRRECVPC PAGCATCTMS TCTNCNDGWT LNEDGLCAPE YRDRCDTSEY YDSGHCKPCH
ASCKTCSGST ENHCISCQNS MLLQGKRCLY QCDDGYYSMV QPSRPVCVPC LHTCKTCVSR
LNCTACHDGL QLQSGECRSS CAQGYYSDRG QCAKCYLSCK TCSGPRRDQC VTCPRGWQLA
AGECHPECPE GFFKSNFGCQ KCHHYCRTCK GEGPMECTSC PPHSMLEGGL CMECLGAQYY
DPLTQLCKNC HADCRRCTGP GKFSCAACSP PLHLDKLNNQ CVPCCTGNEK GPQAEECCLC
DPETGGCRNS SPAGKRRVPG TEFASADTAI SEVYAKYEGT TDKNDSASLA ITATTTIAVA
ICLVSVALFA TIFIALQAMS GRRETNKGYT QLAVRVEPPD DVDADDTTEL MT
//
