ID   A0A0L7R8N3_9HYME        Unreviewed;      1147 AA.
AC   A0A0L7R8N3;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   ORFNames=WH47_11845 {ECO:0000313|EMBL:KOC67188.1};
OS   Habropoda laboriosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC   Anthophila; Apidae; Habropoda.
OX   NCBI_TaxID=597456 {ECO:0000313|EMBL:KOC67188.1, ECO:0000313|Proteomes:UP000053825};
RN   [1] {ECO:0000313|EMBL:KOC67188.1, ECO:0000313|Proteomes:UP000053825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0110345459 {ECO:0000313|EMBL:KOC67188.1};
RA   Pan H., Kapheim K.;
RT   "The genome of Habropoda laboriosa.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   EMBL; KQ414632; KOC67188.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L7R8N3; -.
DR   STRING; 597456.A0A0L7R8N3; -.
DR   Proteomes; UP000053825; Unassembled WGS sequence.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13286; PH_OPR5_ORP8; 1.
DR   Gene3D; 1.10.287.2720; -; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972:SF207; OXYSTEROL-BINDING PROTEIN; 1.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053825};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          157..276
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          463..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          915..944
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          802..829
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        13..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        915..936
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1147 AA;  129210 MW;  054F8CCCC47782FC CRC64;
     MISQPIVVPG GEHRSQSESQ SMSVGSTSDS FKTTTPPNVS RSLSNRISDS GYGTLPKPVD
     QQLRRSSVQV QSATLPKLPS TESLSTSVNF TTAAPPLSPG LSPMGEGNQK TDNISDKSLD
     SCKLTRKESY KAQRKNYRME KKRVANELLS SFKDPTVIVM SDWLKVRGTL KSWTKLWCIL
     KPGLLLLYKS PKTKSNHWVG TVLLNTCQVI ERPSKKDGFC FKLFHPLEQS IWAPRGPEKE
     AIGAVVQPLP TSYLIFRAPS QAAGKCWLDA LELSLRCSSL IVRSTSALPR ALPHDTTTTH
     ETQWSEADYE KHFDEHVCLS NYAPRSPSTP QRRLLSCPQP VTPSIANDSK SICPSPTPMF
     QQLYHAVAYW DKQLRDLSPT LATDTEVVLS SNSVDALGDG DVYSCFESST SKPIPSSTRR
     MTVPSVHVLE YGTPKVVTLD PLHSSHTDLD DISQPENGVA ADAEISASDS ESEGSAKEDQ
     PETVNETPYV ANEQEVLGSA GEVVTELQEE QKSLIWFLMK QVRPGMDLSK VVLPTFILEP
     RSFLEKLADS YYHADLLSQA VVEDDAFTRM KVVVKWYLSG FYKKPQGLKK PYNPLLGETF
     RCYWQHPNGS RTFYIAEQLS HHPPISGFYV TNRQDGFTIS ATIIAKSKFY GNSTSAVLDG
     VAILTMLPRG EDYTMTIPYA HCKGILMGTL TMELGGKIHI NCEKTGYHTE LEFKLKPFLG
     GVEQMNQVAG GIRLGKETLA TISGYWDGQI LITDKRTGQE SVFFNPTPEI RKKRLKKYTV
     PLEHQGLWES EKLWYDVTQA INRDDQIAAT EAKTQLEEAQ RDRAKERKQK GQEWIPKHFV
     QDIITGNWVY RHADVRPWDP RNDVVQYEQD YIVRTKTRHK TPIMRLFTLQ VPLLQAESRS
     SLSVLKSSKR QLSNNLPLTE TAHDSGSSSA EVHSDSSQSV GKRKRSTARI MDIIKEIERQ
     VSEYGDRLNR IQLILEQLAI KQREQGDQHH SISMFKSFID MIRVIVIVFS VQYFIKIWSD
     EPSGGGHISI TPQMVREAVK RLQLRRVYVS SNLISEYLRR SYPIAKDAKE LSEELNKKLD
     CAVRVGLILK RGEDAYYLPT LREEANALKT AFTAFWEMYK NVIASFTTCP LNFFSSYYNS
     SKIFSVP
//