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Database: UniProt
Entry: A0A0L7TIU4_9GAMM
LinkDB: A0A0L7TIU4_9GAMM
Original site: A0A0L7TIU4_9GAMM 
ID   A0A0L7TIU4_9GAMM        Unreviewed;       164 AA.
AC   A0A0L7TIU4;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Leucine-responsive regulatory protein {ECO:0000256|ARBA:ARBA00039227};
GN   ORFNames=NG42_00220 {ECO:0000313|EMBL:KOC92771.1}, NG43_00950
GN   {ECO:0000313|EMBL:KOC95308.1};
OS   Winslowiella iniecta.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Winslowiella.
OX   NCBI_TaxID=1560201 {ECO:0000313|EMBL:KOC95308.1, ECO:0000313|Proteomes:UP000036851};
RN   [1] {ECO:0000313|Proteomes:UP000036851, ECO:0000313|Proteomes:UP000037088}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B120 {ECO:0000313|EMBL:KOC92771.1,
RC   ECO:0000313|Proteomes:UP000037088}, and B149
RC   {ECO:0000313|EMBL:KOC95308.1, ECO:0000313|Proteomes:UP000036851};
RX   PubMed=26198254;
RA   Campillo T., Luna E., Portier P., Fischer-Le Saux M., Lapitan N.,
RA   Tisserat N.A., Leach J.E.;
RT   "Erwinia iniecta sp. nov., isolated from Russian wheat aphids (Diuraphis
RT   noxia).";
RL   Int. J. Syst. Evol. Microbiol. 0:0-0(2015).
CC   -!- FUNCTION: Mediates a global response to leucine. Exogenous leucine
CC       affects the expression of a number of different operons; lrp mediates
CC       this effect for at least some of these operons. For example it is
CC       regulator of the branched-chain amino acid transport genes.
CC       {ECO:0000256|ARBA:ARBA00037041}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOC95308.1}.
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DR   EMBL; JRXE01000001; KOC92771.1; -; Genomic_DNA.
DR   EMBL; JRXF01000001; KOC95308.1; -; Genomic_DNA.
DR   RefSeq; WP_006118610.1; NZ_JRXF01000001.1.
DR   AlphaFoldDB; A0A0L7TIU4; -.
DR   SMR; A0A0L7TIU4; -.
DR   STRING; 1560201.NG42_00220; -.
DR   GeneID; 84690833; -.
DR   PATRIC; fig|1560201.3.peg.48; -.
DR   OrthoDB; 166264at2; -.
DR   Proteomes; UP000036851; Unassembled WGS sequence.
DR   Proteomes; UP000037088; Unassembled WGS sequence.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 3.30.70.920; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30154; LEUCINE-RESPONSIVE REGULATORY PROTEIN; 1.
DR   PANTHER; PTHR30154:SF0; LEUCINE-RESPONSIVE REGULATORY PROTEIN; 1.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   Pfam; PF13412; HTH_24; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF54909; Dimeric alpha+beta barrel; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00519; HTH_ASNC_1; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037088};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          12..73
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50956"
SQ   SEQUENCE   164 AA;  18872 MW;  DAF63C2FD38551BD CRC64;
     MVDNKKRPGK DLDRIDRNIL NELQKDGRIS NVELSKRVGL SPTPCLERVR RLERQGFILG
     YTAQLNPHYL DASLLVFVEI TLNRGAPDVF EQFNAAVQKL EETQECHLVS GDFDYLLKTR
     VPDMSAYRKL LGETLLRLPG VNDTRTYVVM EEVKQSNRLV IKTR
//
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