ID A0A0L8FMH1_OCTBM Unreviewed; 806 AA.
AC A0A0L8FMH1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=VWFA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22014896mg {ECO:0000313|EMBL:KOF65605.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF65605.1};
RN [1] {ECO:0000313|EMBL:KOF65605.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF65605.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF65605.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
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DR EMBL; KQ429131; KOF65605.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8FMH1; -.
DR EnsemblMetazoa; Ocbimv22014896m; Ocbimv22014896m.p; Ocbimv22014896m.g.
DR EnsemblMetazoa; XM_014933249.1; XP_014788735.1; LOC106882533.
DR OMA; KNAFVPR; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF108; VWA DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 22..151
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 276..457
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 606..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 90690 MW; DEF7815CAAC47AE7 CRC64;
MAEKHSSKLT REKEHVHIYT HLNTYAYSYR YGEGSPQVKY LHVRSDVRMR FATTEITSVM
ANNQNYSTDV TFNVYLPDQA FISNFSMVID GEEYAGEVKE KEQAKKAYEK AKKRGQSAGH
VAQKPREANK FKVDINVAAL KEVKFTLRYQ ELLKRKFGIY EHAVYVDPVT PVDDFLIEVF
LAESKEISYL QVPPLRPIDP TIVFNETGKT NPDAEISRPS LKSAKILYKP KANVSGVFVI
KYDVDRREKF NGDIMAVNGY FVHFFAPTDL DPIPKDVLFI IDTSGSMYGR KMTQVKKAMD
QIVNDMAEGD RFNIMDFDSN IKFWKDDMMP WDEKNKEKAL KWIYDRDASG STNINKALVD
GLKLLHNFQL SKLDGRSPLI IFLTDGAASS GITDSNMILQ NVGENNNDEI PLFSLSFGAD
ADFSLLQKIS LRNFAVARRI FEASDTVIQL KNFYNEISAA LMTNLKFDYF GDKVENDSLT
TSQFRRYFKG TESVIAGRLN DDSVSTLRWN LVGSTNAGAI DHTDETELFD PSVVGEGIGL
LKDEDIKGIP EKLWAYITIK QLLDKRIAAT SEEEKEELKQ RAIELSLKYK FVTPVTSMLV
VKPESEYDNP LDTTTPKPTT PPRRSGGYSY GRRGGGGGGG GGGGGGASGD PHFLVYVKNL
TYPVCFDVPA KEGEKLTLIS DPVRALEVTA AMIASKDHYK TGELKTFMGT IFIQSRFTNV
IVTPQYIFFN GQKYLWTNET RIISNNSNLE INGEGHSLMI KISKQQQFLI KRSLAGNRPT
KVDYLNFDVV IGKGFSKSVT GYIGMW
//
