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Database: UniProt
Entry: A0A0L8FQW4_OCTBM
LinkDB: A0A0L8FQW4_OCTBM
Original site: A0A0L8FQW4_OCTBM 
ID   A0A0L8FQW4_OCTBM        Unreviewed;      3703 AA.
AC   A0A0L8FQW4;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   22-NOV-2017, entry version 17.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KOF67048.1};
GN   ORFNames=OCBIM_22010659mg {ECO:0000313|EMBL:KOF67048.1};
OS   Octopus bimaculoides (California two-spotted octopus).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Cephalopoda; Coleoidea;
OC   Neocoleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae;
OC   Octopus.
OX   NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF67048.1, ECO:0000313|Proteomes:UP000053454};
RN   [1] {ECO:0000313|Proteomes:UP000053454}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Albertin C.B., Simakov O., Mitros T., Wang Z.Y., Pungot J.R.,
RA   Edsinger-Gonzalez E., Brenner S., Ragsdale C.W., Rokhsar D.S.;
RT   "WGS assembly of Octopus bimaculoides.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KQ427464; KOF67048.1; -; Genomic_DNA.
DR   EnsemblMetazoa; Ocbimv22010660m; Ocbimv22010660m.p; Ocbimv22010659m.g.
DR   Proteomes; UP000053454; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 4.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053454};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053454};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3040   3062       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3249   3267       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3307   3333       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3502   3525       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3579   3602       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      146    363       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     2794   2822       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     2825   2857       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    2800   2811       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    2835   2846       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   3703 AA;  419291 MW;  BFC18C09FDCC3796 CRC64;
     MFSHEEMISC LERALHHDYA GDESLSDADQ RRTSFLRNKN AHHSLDEPTL HDSSLPGMKT
     AASESHLVDS YLGIDNERKK STSKLSLLAE KLSDPKASKA AKNSKSPFAT LFRRSKSREP
     SPTPRDMKSK TLDSLKPGKL GRSQRSNRSI AGSQNIQKGN VEGGSPAINI EGPDGLIPYE
     FQDVKDIHHG FSNVSMGSDY EMSEAEIAEM NALTETMHEY YYSVRIFPGQ DPNQLYVGWV
     TPGFHMGGRS FDMKKIRNVI ISTQDVEYKY RQSVSRKNCY MVCAGVLQQR YGGTHEESSK
     KSSPGLVIGC YIDTATGILS FSVNGKEVAN KYQVEPGTKL FPAVIFEPTI KEMFQFELGR
     TKNTLPLSAA LFRGPKSIQP ACPPRLDLQV IKPSHWARVP NTSLKSHSIK MSEVRGWSLV
     CDEPVSMMAV YIPEEDSCLD VLELIEHPLL LNFHARTLDL YQAVCSHGNH RVAHALTRHI
     DEKQLYYCIE SELKHGLLSM ELAEPVKVEM CRILQHLCDY QLRHRVETIV AFSDHFVGEC
     QTDQLRRYNT IKQSDLPSAV TAKKTREFRC PPQQQMKNLL KFKSEEEFDE DICACREDFR
     ESLLNYHQTL MIHCEMPTLQ KQPEANETEQ LDDSPKSMKE KLKCLIWRVK KEEEIKEKSS
     DEETKNDSLQ KLIAQTMVRW GEETFLSDQN LVREMFSLLH RQYNGVAELL SALEKAYVIS
     NSSIEDINEL LKALGHIRSL LLVQVAVDEE ESMKTSLKEL MDNKVFFQHP DLMRALCVHE
     TVMQLMVNTL NKAQQHQQAA ASEQAAGNRT SIAGAPSESD PSAVQSKQDA CAEMVVMCCR
     FLCYFCRISR QNQRAMFEHL SYLLENSSML LARPSLRGSC PLDVAYSSLM DNNELALALR
     ESNLERITVY LSRCGLQSNA ELLEKGYPDI GWDPVEGERF LDFFRFCVWV NGESVEENAN
     LVVRLLIRKP ECLGPALRGE GSGLLKATRD GIKMSEQIAA AKDTNAANFL RVINDDDDTA
     DDDEDYIDMG CAILNFYSSL VDLLGRCAPD AETLKAGRSN SLRARAILRS LVSMEDLEGV
     LGLRFILPSG FGQYEEGVPV PLPPGLVPTH KAAIVLFLER VYGIPDRTVF FRLLEDGFLP
     DLRAATSLDT VTPDESDMAL ALNRYLCNSV LPLMTTHCHF FRDADHVSAL MDNTLNTVYR
     YTKCRSLTKG QRDVVCDFLV AFTHQLRPPM MTKLLRKMTV DVPALSDSAV VPLRLLTSHY
     ERCGSYYGSH GGWGSFGSAS EEERRLTMVL FSGIFDSLAQ RGYDPELFSR ALPCLSAIGC
     AMSPDYSLTN QDDISTVQGV EAEYVPNPVN TKSITLNPAL EAVVSKFAEH YHDCWAVKKV
     DQAWVYGTEY NEDKKTHPSL KPYHLLTEAE KFKYTEPVRN SLKCTIALGW SLDCEDSRLL
     QSNEGIKRRA SKSNVHDQGY SPRPYDLRNM TVTREMQRIQ KELDESNGDY KDMEAWKTRS
     DHSDKKRNPE FVDEKNFCQD QMVKAQNNCW LAMSPEQVPR VIKIKQPVNI MMFGVITSDG
     DVMPPFIFPH GLTLNTEAYI KCLEKNLAER LAENMHEVWF KQKKLDLESI GGGIHPLLVP
     YDSLTDHEKK KDKEHAQELL KFLQFLGFRI SCMSQHTHES SSRHGKDNDG GASVSATEKR
     FAYSLLQKLL EYLDKASINM KQTKPSSRFS RRESYTTATE DVKFFGKVVL PFVERYFHAH
     RLYFIASPTS PSSSGMASSK EKEMTATLFC KLAQALRSKI NAFGHDVNIS VRCLQVLVQA
     VDARSVVKNS PEIIRAHFMP FFNNAAADLA NLMDNLHKGR FSHVKGTITR GATSLNYVHM
     VLLPVLSSLF EHLGHNSYGA DILVGEVQLA CYRILNALFS LGMSGSSFSH RHRPVLGECI
     GAFASCFPVA FLEPKLNTYN KFSVMYGIKG NIAEHSLEAQ DVMDSLSECV PGLESIITDI
     DKLAESGGDC QDSPHIMDVT LPMLCSYLPF WWSQGPDNAS STDGNHVTTV TATLMNEVLG
     KVLRLILNNV NNPNASWMNR IASRVQPIIG NSTPYMVEEH FLPIAKKIQT CALNVEHAEK
     KLSDRRVSSD NSDLEGELQQ YYGVLVRDLY AFYPLLIKYV DLHRSSWLKN PIVAAEELFN
     CVAYIFTLWS KSLLFKREEQ NFVSQNEIDN MALIMPSQAK GLSVVKVEDD QTRQTSGRKK
     DKKRLEAHNS LNVACLKRLF PIGLSFFSGR EQELLQYTKE KLIRKEPEGD IETFLKALLE
     TVEGEVEPEQ WQKLLFRKIG DSKLSSNIEL NSEKSIERIV SMARVMFGLH MVEHPSLGLK
     GAWRKVISSQ RKRAVMACFR MVPLYGLPRH RAMNLFLKAY RLTWLATEEV SKNVLIEDLT
     IAKEEEEEVE KKEVEEDKKP DPLNQLIIAL CRGATKEQSD GLEADELYIA YADIMSKSCH
     GEDEDDDDDG GDDATTSLQE QEMEKQQLLS EQSRLSERGA AEMILLYISA TKGVYSPIVD
     HTIELGISLL RGGNIDVQKR MLKHLKDKKD VGFFTSVAGL MQQCSVLDLD AFERCNKAEG
     LGMSTDTGPG EKNLHDAEFT CKLFRFLQLL CEGHNLEFQN YLRTQAGNNT TVNIIICTVD
     YLLRLQESIM DFYWHYSGKD LIDPAGKANF CRAIMVAKYV FRSLTEYIQG PCAQNQLALA
     HSRLWDAVGG FLYIFAQMQD KLSKDFEQLE LLREFMNLQK EMMIMLLSML EGNVMHGPIG
     KQMVDTLVES SGNVEMILKF FDIFLKMKNI TSSESFLDYD TNRDGYISVK EFRQLMESQK
     MYCREEIDYI MMCVDVDQDG KVDYDEFTER FHNPAKDIGF TMAVLLTNLS EHSPNDPRLE
     RFLEKARSVL DYFKPYLGRI EIMGSANRIE RIYFEIKQSQ IDQWEKPQIK ESKRSFLHSV
     INEGGDKEKL ESFVNFCEDT IFEMQHATSI TGEELKLSSV IGGVGAGSIL EPVKATYRTI
     RDFIGSLLSL FTWSNIKNTY HTFRSMTYGQ LFMMILKGNF QFGLSILTLI FHIFWTLAKF
     LINMMMGDRG MEVTSDAVKA AATKHPPAIM PAPLALGAPE TPSGAAPAGP KVTQENGGPV
     KTFPAKKENG LKESISVTEG QTAPEVDVTT VNGSVPSKEL PSATSEGVNE MLLEEKFLIA
     ESVPEIPAPA GTSTNEATNG TPTTESGKGE ELEGEEGVVT GEEEVPYETK AFDYGKYILS
     YFARNFYNFK YVALALAFFI NFILLFYKVN KVTQAMVGGE EESTGSNGTS DEDDAEEVVM
     MEEDVDYLLP VLEVLAVLHS IASFSMLVAY YCLKVPLVIF KREKEIARKL EFEGLYIAEQ
     PDEDDIKAQW DKLVLSTGSF PQSYWDKFVK KKVRLRYAEQ YDYESISNLL GMKKGDSITI
     EDTVQHTGML PAFLSNMDWQ YQLWKWGVIF TDNSFLYILW YFTFSVLGNF NHFFFAAHLI
     DVAIGFKTLR TILQSVTHNG KQLVLTVMLT SIVVYIYTVI AFNFFRKFYV KEEDGQVDYK
     CHDMATCFVY HLHTGLRAGG GIGDEIEPAD GDPSEAYRII FDITFFFFII VILLAIIQGL
     IIDAFGELRD QLEQVKEDME SKCFICGIGK EFFDKVPHGF DTHVMNEHNF ANYMFFLMHL
     INKPDTEYTG QETYVWEMYQ QRCWDFFPVG DCFRKQYEDE ASS
//
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