ID A0A0L8GJD3_OCTBM Unreviewed; 468 AA.
AC A0A0L8GJD3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Ras guanyl-releasing protein 3 {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22032542mg {ECO:0000313|EMBL:KOF77068.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF77068.1};
RN [1] {ECO:0000313|EMBL:KOF77068.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF77068.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF77068.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ421581; KOF77068.1; -; Genomic_DNA.
DR EMBL; KQ421581; KOF77071.1; -; Genomic_DNA.
DR STRING; 37653.A0A0L8GJD3; -.
DR EnsemblMetazoa; Ocbimv22032542m; Ocbimv22032542m.p; Ocbimv22032542m.g.
DR EnsemblMetazoa; Ocbimv22032545m; Ocbimv22032545m.p; Ocbimv22032542m.g.
DR EnsemblMetazoa; XM_014925034.1; XP_014780520.1; LOC106876470.
DR OMA; CKDCTIN; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd20808; C1_RASGRP; 1.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF252; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR HOMOLOG; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF13202; EF-hand_5; 2.
DR Pfam; PF00617; RasGEF; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..179
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 212..247
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 250..276
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 283..333
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
SQ SEQUENCE 468 AA; 53605 MW; D894B8DA61147B60 CRC64;
MVLNRTTPAQ RAEVIVKFIN VAQKLRNLQN FNTLMAVVGG LTHSALARLS KTNACLSSDT
QKLLIELTEL LSTNNNFSNY RRQYQQCTGF RVPILGVHLK DLISLHTALA DKVDGVSTSL
IHFRKMVQLY QIFKELTCLQ NENLPLDTNM DLVNTLRLSL DMHYTEDNIY ELSLAREPRS
SLSAPVTPTK PVVFADWVAG VSPPDAETIN KHVHNMVEAV FKNYDHDKDG FICNAEFEAI
AGNFPFIDSF CVLDADKDGM ISKSEMKTYF IRANCHSLRS SFKHDFHEKT YFQPTFCTHC
TGLLWGLIKQ GWKCKDCTIN VHKHCKDMVV MECRPKLNSP RRHDSVFNDS EYGCYNNKHR
MFHDSKSHRS TQTDNELLLT PNTKPLSEAP VNGEEFYEEQ SLLYDRLLKA EEAREKMIAE
NAFLKSCLDM SLEQNVTLKC QIGLIRQHTI SFILNQMDIL NLYKESEV
//
