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Database: UniProt
Entry: A0A0L8GMK9_OCTBM
LinkDB: A0A0L8GMK9_OCTBM
Original site: A0A0L8GMK9_OCTBM 
ID   A0A0L8GMK9_OCTBM        Unreviewed;       450 AA.
AC   A0A0L8GMK9;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   22-NOV-2017, entry version 16.
DE   RecName: Full=6-phosphogluconate dehydrogenase, decarboxylating {ECO:0000256|RuleBase:RU000485};
DE            EC=1.1.1.44 {ECO:0000256|RuleBase:RU000485};
GN   ORFNames=OCBIM_22031591mg {ECO:0000313|EMBL:KOF77865.1};
OS   Octopus bimaculoides (California two-spotted octopus).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Cephalopoda; Coleoidea;
OC   Neocoleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae;
OC   Octopus.
OX   NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF77865.1, ECO:0000313|Proteomes:UP000053454};
RN   [1] {ECO:0000313|Proteomes:UP000053454}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Albertin C.B., Simakov O., Mitros T., Wang Z.Y., Pungot J.R.,
RA   Edsinger-Gonzalez E., Brenner S., Ragsdale C.W., Rokhsar D.S.;
RT   "WGS assembly of Octopus bimaculoides.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 6-phospho-D-gluconate + NADP(+) = D-ribulose
CC       5-phosphate + CO(2) + NADPH. {ECO:0000256|RuleBase:RU000485}.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 3/3. {ECO:0000256|RuleBase:RU000485}.
CC   -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU000485}.
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DR   EMBL; KQ421283; KOF77865.1; -; Genomic_DNA.
DR   EnsemblMetazoa; Ocbimv22031591m; Ocbimv22031591m.p; Ocbimv22031591m.g.
DR   OMA; NSHYPDS; -.
DR   UniPathway; UPA00115; UER00410.
DR   Proteomes; UP000053454; Unassembled WGS sequence.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 3.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006114; 6PGDH_C.
DR   InterPro; IPR006113; 6PGDH_Gnd/GntZ.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR006184; 6PGdom_BS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006183; Pgluconate_DH.
DR   Pfam; PF00393; 6PGD; 3.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000109; 6PGD; 3.
DR   PRINTS; PR00076; 6PGDHDRGNASE.
DR   SMART; SM01350; 6PGD; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00873; gnd; 1.
DR   PROSITE; PS00461; 6PGD; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053454};
KW   Gluconate utilization {ECO:0000256|RuleBase:RU000485};
KW   NADP {ECO:0000256|RuleBase:RU000485};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000485};
KW   Pentose shunt {ECO:0000256|RuleBase:RU000485};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053454}.
FT   DOMAIN      166    437       6PGD. {ECO:0000259|SMART:SM01350}.
FT   ACT_SITE    170    170       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000109-1}.
FT   ACT_SITE    177    177       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000109-1}.
SQ   SEQUENCE   450 AA;  49521 MW;  876C358531372795 CRC64;
     MGQNLILNMN DNGYVVCAFN RTVSKVTNFL ENEAKGTKVI GATSLEDMVS KLKKPRRVMM
     LVKAGQAVDD FIDKLVPLLE KGDIIIDGGN SEYQDTTRRC KSLEAQGLLY IGTGVSGGEE
     GARHGPSMMP GGSPAAWPHV KDIFQSISAK VGNEPCCNWV GEEGAGHFVK MVHNGIEYGD
     MQLICEAYHL MKDVLELSPT EMAQVFDDWN KEELNSYLIE ITRDILQYKE NGEFLLGNIS
     DAAGQKGTGK WTAIAALQYG TPVSLIGFML MREAAKSLGW NLNYGSIALM WRGGCIIRSV
     FLGNIKEAFD KNPKLKSLLL DEFFKSAISK CQHGLDWELV KPDGNTRLQS DLAEFLQLDA
     LPNANHSESV ESWRHVVSTA VASGIPTTAF SSALAFYDGY RTSHLPANLI QAQRDYFGAH
     TYELRNNLGH FIHTNWTGSG GQVSSTTYQA
//
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