ID A0A0L8GWC4_OCTBM Unreviewed; 775 AA.
AC A0A0L8GWC4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Serine protease 12 {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22026774mg {ECO:0000313|EMBL:KOF81273.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF81273.1};
RN [1] {ECO:0000313|EMBL:KOF81273.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF81273.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF81273.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR EMBL; KQ420113; KOF81273.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8GWC4; -.
DR STRING; 37653.A0A0L8GWC4; -.
DR EnsemblMetazoa; Ocbimv22026774m; Ocbimv22026774m.p; Ocbimv22026774m.g.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00112; LDLa; 6.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 6.
DR Gene3D; 3.10.250.10; SRCR-like domain; 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48071:SF22; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR Pfam; PF00530; SRCR; 2.
DR Pfam; PF00089; Trypsin; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00192; LDLa; 6.
DR SMART; SM00202; SR; 2.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 6.
DR SUPFAM; SSF56487; SRCR-like; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 6.
DR PROSITE; PS50948; PAN; 1.
DR PROSITE; PS50287; SRCR_2; 2.
DR PROSITE; PS00134; TRYPSIN_HIS; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 173..255
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 297..396
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 439..538
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DISULFID 16..31
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 57..72
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 100..115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 158..173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 255..267
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 262..280
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 274..289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 321..385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 334..395
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 365..375
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 401..413
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 408..426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 420..435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 507..517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 775 AA; 86095 MW; E2D8EA4E9A3A4769 CRC64;
MLCSGSRTCI PISWKCDGEN DCPDGEDEKG CEPEVSCPTN SMMCSSRKIC IPLQWKCDGD
RDCPGGEDES ECGTTTNSSF TCPPDKMKCL QSCLPESWRC DGSADCPDSS DEKNCTATTK
ATVTTTQAPV TTTHSLNCPL NKMYCSTSKT CISLSWKCDG ENDCSDGEDE KDCDYTLDNF
EKQDTNFIID AFPREVYVRI PLETCARTCL YHREFVCKAF HYRENGKQCK LFDTMKSLSM
RPLSSGFYYI LSQNCTATGF QCQNGRCIPE EEKCNGRDDC NDFSDEQDCG IPEMLEIRLA
DGEEHSGRVE IKYLNEWGVV CDDKWDIKDA NVVCRMLGYT AAVKAIPFSN FGPGNANFLL
TNVECLGNET SLLDCPKSPW RQHNCKRHET ASVICKLDKG CPPNQFECAN SQCRNIDQIC
DTVNNCGDNS DEKYCTASVK LVNGTNPSNG RIQITINNIT GTICDDNFDD KDATVVCKQL
GYKSGIALPG GTYGKGKGII WYDEVECFGD EDSIGYCEGN RRGEHDCDHT EDVGVQCYKD
AITTTTFLTS TTVATTTTVA PPVCGKIPRL VRTKRADRVI DKTSYSKIVN GKDAVYGRYP
WQVTVQRITG QYSGSYFTTS HFCGGTIVHR DWIVSAAHCF VLQSDLAEFL QLDALPNANH
SESVVDAFTC HWHEGQSDGT GNGHAQNGVF YAPPAQEPQG NWQRSRSKIL TNNLKCGRRP
IKQRSQRITG GVRAIEGAYP WQARIFRSWF WGRLHHCGAS VIGELWVITA AHCVM
//
