ID A0A0L8HC00_OCTBM Unreviewed; 1827 AA.
AC A0A0L8HC00;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Titin {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22017953mg {ECO:0000313|EMBL:KOF86826.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF86826.1};
RN [1] {ECO:0000313|EMBL:KOF86826.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF86826.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF86826.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; KQ418560; KOF86826.1; -; Genomic_DNA.
DR EnsemblMetazoa; Ocbimv22017936m; Ocbimv22017936m.p; Ocbimv22017953m.g.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08317; Death_ank; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24198; ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24198:SF165; IPT_TIG DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 7.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 36..68
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 69..101
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 102..134
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 135..158
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 207..239
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 240..272
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 273..305
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 306..338
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 339..371
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 372..404
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 405..437
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 438..470
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 471..503
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 504..536
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 537..569
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 570..602
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 603..635
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 636..668
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 669..701
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 702..734
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 735..767
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1052..1217
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1219..1366
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1554..1637
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1692..1736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1791..1827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1692..1725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1802..1816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1827 AA; 200490 MW; FA16573C789E789D CRC64;
MSDGNSSFLR AARDGNLSEV LEYLKGSTDI NTSNSNGLNA LHLASKEGHI NIVTELLRRG
ANVEAATKKG NTALHIASLA GHEEIVKILV QNGAKVNVQS MTGFTPLYMA AQEGHSEVVK
FLLDNGASQS LATVDGFTPL AVALQQGHDK VVAVLLEHDT KGKVRLPALH IAAKKDDIGS
ANLLLQNDHN ADSSTKSGGL VNDTTKSGFT PLHIAAHYGN VNVGTLLIQK GADVNYKAKN
NITPLHVASR WGKSNMVILL LDHDATIEER TRDGLTPLHC AARSGHENVV DLLLERGAPF
SAKTKNGLTP LHMAAQGDHV DCARLLLYHK ALVDDVTVDY LTPLHVAAHC GNVKTAKLLL
DRKSDPNARA LNGFTPLHIA CKKNRIKVVE LLLKYDASIE ATTESGLTPL HVASFMGHMN
ISIYLIQHNA NPDYPTVRGE TALHLAARAN QTDIIRILLR NGATVDAKAR EQQTPLHIAA
RLGNVDNVVL LLQHGASPNA TTKDLYTPLH IAAKEGHEEV AAALLDQGAD HSLTTKKGFT
PLHIAAKYGN IKVARLLLLK NAEPDVQGKN GLTPLHVATH YNHVNVALLL LDNKASPQAM
AKNGYSPLHI AAKKNQMDIA TTLLEFGANP AAGSKNGFTP LHLASQEGHT DMVSLLLEHK
ANVNDKATNG LAPIHLAAQE DKVNVAEVLV KFGSEIDPQT KAGYTPLHTA CHFGQTNMVR
FLLDHNASVS STTKLGYTPL HQAAQQGHVM VINLLLKNKA SPNAVTNTGQ TALSIAQRLG
YISVVDTLKN LTEVTETLPA IEDKYKVVAP ETMTETMLSD SEDEGEDTIS IEKGDITSPL
DLSFDKDLRK VRATSQEART RDISPGLAYP KYLEKGPDYE AEMIYYSGDV LSPQEKHQQG
HDSVIANGFS TLDQLSPSLE RDRLSTCDKD SAFDRESILG RHSPYPQQAE LAYARNVSSR
PPTSLGSYID DENLSYVDDI DSSSLQQQDY LEHQIISHTY ASHPDNRYLN NTMESSRYSS
YSGSSFNTSF DPDNVAVDRT PTYSGKLKWK SFLVSFMVDA RGGAMRGSRH SGVRIIIPPR
KAYMPTRVTC KLIKREKLSH PPPLNEGEAL ASRILEMGPV GVKFLGPVII EVPHFASLRG
KEREIAIIRC DDGEKWTEHP ILATEEAVND TLNGSFEGQN SSASSLWKLD QEDELVAKRI
TRILTTDFPM YFAIVTRVRQ ENQTIGFEGG MLSSTVVPQV QTIFPEGALT KKIPVGLQAQ
PIAPELVAKM LGNRVAVSPI VTVAPRRRKF HKPITLTIPV PRAAQKGMIN QYGGEAPTLR
LLCSISGGTT PAVWEDITAS TQLTFVNDCV SFTTTVSARF WLMDCQNVNE ASRMATELYQ
EAVVVPFMAK FVIFAKRHAP EEGKLRMFCM TDDKIDKTLE KQEKFTEVAR SRDVEVLQGR
PQYVEMAGNL IPVTKSGDQL YVHFRAFREN RLPCTVKVRD LDQEAAARVA FMKEPKVARG
EAPQSPICNL NIVLPDVSKA DSTEITSEEA LEVRKRHSLL REHGIVLQDT ISRAQMKIVD
VADTLQGDWV MLAQQLDITM SEINKIKTDY NTVNDQALAM LHLWVEKNGE KASGNALEKA
LIRINREDVV KKCMYDVVTV EDEVDMAAGR VAMDQSGFDT FKEEVGISRD SSMKRGISLD
VSYDEQDMIK MKKSPEIKSL HSKILESESA EESGSDADTE RHRIAKAPPP PAAMSQDEVL
VKHVDHRRPE AAPVAESSVD DTDRKKNAFV EFARQMDELS DMEETIKPVA TSEQELVSHR
TTELAQARDR LSEEMESNQH TPSATGV
//
