ID A0A0L8HCF5_OCTBM Unreviewed; 1873 AA.
AC A0A0L8HCF5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Titin {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22017953mg {ECO:0000313|EMBL:KOF86749.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF86749.1};
RN [1] {ECO:0000313|EMBL:KOF86749.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF86749.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF86749.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; KQ418560; KOF86749.1; -; Genomic_DNA.
DR EnsemblMetazoa; Ocbimv22017970m; Ocbimv22017970m.p; Ocbimv22017953m.g.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08317; Death_ank; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF33; ANKYRIN 2, ISOFORM U; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 7.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 36..68
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 69..101
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 102..134
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 135..158
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 197..229
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 230..262
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 263..295
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 296..328
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 329..361
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 362..394
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 395..427
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 428..460
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 461..493
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 494..526
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 527..559
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 560..592
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 593..625
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 626..658
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 659..691
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 692..724
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 725..757
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1042..1207
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1209..1356
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1544..1627
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1679..1711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1824..1873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1679..1700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1839..1862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1873 AA; 205218 MW; 197F9AFB545B2A5A CRC64;
MSDGNSSFLR AARDGNLSEV LEYLKGSTDI NTSNSNGLNA LHLASKEGHI NIVTELLRRG
ANVEAATKKG NTALHIASLA GHEEIVKILV QNGAKVNVQS MTGFTPLYMA AQEGHSEVVK
FLLDNGASQS LATVDGFTPL AVALQQGHDK VVAVLLEHDT KGKVRLPALH IAAKKDDIGS
ANLLLQNDHN ADSSTKSGFT PLHIAAHYGN VNVGTLLIQK GADVNYKAKN NITPLHVASR
WGKSNMVILL LDHDATIEER TRDGLTPLHC AARSGHENVV DLLLERGAPF SAKTKNGLTP
LHMAAQGDHV DCARLLLYHK ALVDDVTVDY LTPLHVAAHC GNVKTAKLLL DRKSDPNARA
LNGFTPLHIA CKKNRIKVVE LLLKYDASIE ATTESGLTPL HVASFMGHMN ISIYLIQHNA
NPDYPTVRGE TALHLAARAN QTDIIRILLR NGATVDAKAR EQQTPLHIAA RLGNVDNVVL
LLQHGASPNA TTKDLYTPLH IAAKEGHEEV AAALLDQGAD HSLTTKKGFT PLHIAAKYGN
IKVARLLLLK NAEPDVQGKN GLTPLHVATH YNHVNVALLL LDNKASPQAM AKNGYSPLHI
AAKKNQMDIA TTLLEFGANP AAGSKNGFTP LHLASQEGHT DMVSLLLEHK ANVNDKATNG
LAPIHLAAQE DKVNVAEVLV KFGSEIDPQT KAGYTPLHTA CHFGQTNMVR FLLDHNASVS
STTKLGYTPL HQAAQQGHVM VINLLLKNKA SPNAVTNTGQ TALSIAQRLG YISVVDTLKN
LTEVTETLPA IEDKYKVVAP ETMTETMLSD SEDEGEDTIS IEKGDITSPL DLSFDKDLRK
VRATSQEART RDISPGLAYP KYLEKGPDYE AEMIYYSGDV LSPQEKHQQG HDSVIANGFS
TLDQLSPSLE RDRLSTCDKD SAFDRESILG RHSPYPQQAE LAYARNVSSR PPTSLGSYID
DENLSYVDDI DSSSLQQQDY LEHQIISHTY ASHPDNRYLN NTMESSRYSS YSGSSFNTSF
DPDNVAVDRT PTYSGKLKWK SFLVSFMVDA RGGAMRGSRH SGVRIIIPPR KAYMPTRVTC
KLIKREKLSH PPPLNEGEAL ASRILEMGPV GVKFLGPVII EVPHFASLRG KEREIAIIRC
DDGEKWTEHP ILATEEAVND TLNGSFEGQN SSASSLWKLD QEDELVAKRI TRILTTDFPM
YFAIVTRVRQ ENQTIGFEGG MLSSTVVPQV QTIFPEGALT KKIPVGLQAQ PIAPELVAKM
LGNRVAVSPI VTVAPRRRKF HKPITLTIPV PRAAQKGMIN QYGGEAPTLR LLCSISGGTT
PAVWEDITAS TQLTFVNDCV SFTTTVSARF WLMDCQNVNE ASRMATELYQ EAVVVPFMAK
FVIFAKRHAP EEGKLRMFCM TDDKIDKTLE KQEKFTEVAR SRDVEVLQGR PQYVEMAGNL
IPVTKSGDQL YVHFRAFREN RLPCTVKVRD LDQEAAARVA FMKEPKVARG EAPQSPICNL
NIVLPDVSKA DSTEITSEEA LEVRKRHSLL REHGIVLQDT ISRAQMKIVD VADTLQGDWV
MLAQQLDITM SEINKIKTDY NTVNDQALAM LHLWVEKNGE KASGNALEKA LIRINREDVV
KKCMYDVVTV EDEVDMAAGR VAMDQSGFDT FKEEVGISRD SSMKRGISLD VSYDEQDMIK
ESESAEESGS DADTERHRIA KAPPPPAAMS QDEVLVKHVD HRRPEAAPVA ESSVDDTDRK
KNAFVEFARQ MDELSDMEET IKPVATSEQD EKPSITEETI VSRVKGAGTV TSVITKTVVT
ETVAKEAIVK DEAPEVMAPC VDVADSRSSS GSSICDKEQQ ELVSHRTTEL AQARDRLSEE
MESNQHTPSA TGV
//
