ID A0A0L8HFF6_OCTBM Unreviewed; 852 AA.
AC A0A0L8HFF6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Histone acetyltransferase GCN5 {ECO:0000256|ARBA:ARBA00019713};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN ORFNames=OCBIM_22015912mg {ECO:0000313|EMBL:KOF87864.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF87864.1};
RN [1] {ECO:0000313|EMBL:KOF87864.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF87864.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF87864.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the acetyltransferase family. GCN5 subfamily.
CC {ECO:0000256|ARBA:ARBA00008607}.
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DR EMBL; KQ418303; KOF87864.1; -; Genomic_DNA.
DR RefSeq; XP_014772776.1; XM_014917290.1.
DR AlphaFoldDB; A0A0L8HFF6; -.
DR STRING; 37653.A0A0L8HFF6; -.
DR EnsemblMetazoa; Ocbimv22015912m; Ocbimv22015912m.p; Ocbimv22015912m.g.
DR EnsemblMetazoa; XM_014917290.1; XP_014772776.1; LOC106871034.
DR GeneID; 106871034; -.
DR KEGG; obi:106871034; -.
DR OMA; YFQTKMR; -.
DR OrthoDB; 1760108at2759; -.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd05509; Bromo_gcn5_like; 1.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR037800; GCN5.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR009464; PCAF_N.
DR PANTHER; PTHR45750; GH11602P; 1.
DR PANTHER; PTHR45750:SF3; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF06466; PCAF_N; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51186; GNAT; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 521..669
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
FT DOMAIN 760..830
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 37..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 97233 MW; 78A40E306EE879CA CRC64;
MASTNGDTSS VITSSNLSSS VAMSQVSTTE TTVLTASMSN STASTTESQS TTTITTGRQI
SQPSTTGEMS RSNTMQRIAH KKAMVKGYPR PKKLEKLAVY SSCKTEGCNC NGWKNPNPPP
TPPRVDVSQP LASLTDPCRS CSHTLGAHVS HLENVAEEEL NRLLRIVVDV ENLFMCVHKE
EDTETKRVYF HLFKLLRKCI MNMCKPSIDM AIGTPPFEKP SIAKGVTNFV LYKFGHLAQK
EWQTMYDLAK MFLHCMNHWK LENPTLHTQH TNMDDRNNYQ SNYTRWLCYC HVPALCDSLP
RYETTLIFGR TLLRSVFETM RRQVLDKFRA EKEMMPPEKR TLVLTHFPRF LSMLEEEVYG
NNSPIWDPDF CQSTTGMSLS PSRISGNAFI ASTNASTVGG VNRFTNSTPT TSTASGTEGS
NTVKSNYSTP TNSHPTKTKD GGTGDKRHLD EIQTSEVIKK RKIEGDVDQE LVAEIVSLIT
DPEHMVGPDK TLFPTHAARD EIARQEEGKG VIEFKVMANT FTERPSREQL IWLIGLQNVF
SHQLPRMPRE YITRLVFDPK HKCLALIKEN RVIGGICFRM FPTQGFTEIV FCAVTSNEQV
KGYGTHMMNH LKDYHIQHGI LHFLTFADEY AIGYFKKQGF SKDIKLQKSA YLGYIKDYEG
ATLMGCELNP RIHYTCFSQI IRRQKEIVKK ILEKKQELQD KVYPGISCFK EGVRQIPVES
IPGLLEAGWK TSPNNNIQKE PDPDPERLQS VLKMILLQVK NHQSAWPFQK PVDKTEAPDY
LEHIRFPMDL KTMSDRLKNR YYCNKRLFTA DMTRIFTNCR AYNQPDTDYY KCANTLDKFF
QSKLKEYNLW DK
//
