ID A0A0L8HL42_OCTBM Unreviewed; 381 AA.
AC A0A0L8HL42;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Neurotransmitter-gated ion-channel ligand-binding domain-containing protein {ECO:0000259|Pfam:PF02931};
GN ORFNames=OCBIM_22012265mg {ECO:0000313|EMBL:KOF89937.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF89937.1};
RN [1] {ECO:0000313|EMBL:KOF89937.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF89937.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF89937.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KQ417896; KOF89937.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8HL42; -.
DR STRING; 37653.A0A0L8HL42; -.
DR EnsemblMetazoa; Ocbimv22012265m; Ocbimv22012265m.p; Ocbimv22012265m.g.
DR EnsemblMetazoa; XM_014915937.1; XP_014771423.1; LOC106869990.
DR OMA; NHERIPR; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18989; LGIC_ECD_cation; 1.
DR CDD; cd19051; LGIC_TM_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF942; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA6, ISOFORM E; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..381
FT /note="Neurotransmitter-gated ion-channel ligand-binding
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005583751"
FT TRANSMEM 276..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..172
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
SQ SEQUENCE 381 AA; 43161 MW; AC9A731BFA211D0D CRC64;
MKLIAVLIFT LIGSISSKRS ALRDMLLKKY DKTKRPVEYD DDILYANVSL TLKKIIELDI
LKGDIASNLI LGFEWNDVNL KWTDSQYNIS YINVKLSDVW YPNIQICNSV TGKFSFDDNK
EVTVNRNGDV NLYIDKIFET YCRINVEKYP FDEHECDISV CFEHQMYVEE TVGEFDYEVK
LQSASNQWDF NFEKSDVEND NIVAVGFIIY GKRKVSSATI TKIIPPIMLT LLVLSVHLLP
PESGEKVSVA ITVFLTNIVF LSETEKILGN NSQDASIYLM YLLILTLVSG CSSVFSIIVC
KLYANQTGAN TNSAPEITQE SNGQRNRVGV SEISDEQNIK ITATKPCKKH LLTYKKLDQI
ILLIIVIFLL LFIIISVSTS S
//
